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Biomedical subjects

K Thestrup-Pedersen

Publications and source records attributed to K Thestrup-Pedersen.

At least 217 records · Page 12Linked to original sources
PubMed1980

Subpopulations of T lymphocytes in a patient with fulminant mycosis fungoides.

A patient with fulminant Mycosis fungoides was found to have a very high percentage of T lymphocytes with Fc receptors for IgG and a low percentage of T lymphocytes with Fc receptors for IgM. The total number of T lymphocytes was normal, but the in vitro function of the lymphocytes was depressed in short-term cultures, though not in cultures of 5 days' duration. T lymphocytes with Fc receptors for IgG are considered to have suppressor functions, and the immunological changes in this patient may be explained by an increased suppressor cell activity. Other investigators have proposed that the abnormal lymphocytes in Mycosis fungoides are T helper cells. After treatment with electron beam and transfer factor, our patient developed uraemia due to uric acid crystallization in the kidneys. This complication to the treatment given seems not to have been reported before.

Aged↗
PubMed1980

HLA antigens in methotrexate-induced liver cirrhosis.

HLA typing was carried out in 20 psoriatics with methotrexate-induced liver cirrhosis and 44 methotrexate-treated psoriatics who at the time of investigation had not developed cirrhosis. The data were compared with results from tissue typing of 1291 healthy individuals. The antigen combination A1, B8 was found to be increased among patients with cirrhosis vis-à-vis methotrexate-treated psoriatics who did not develop liver cirrhosis. This finding is similar to data on chronic active hepatitis type A and drug-associated chronic active hepatitis. Findings of the antigen combination A1, B8 should--just as with other predisposing factors--lead to caution in liver control in psoriatics on methotrexate therapy.

Epitopes↗
PubMed1979

Transfer factor in mycosis fungoides: a case report on a patient "cured".

A report is given of the successful treatment with transfer factor as an additional therapeutic agent of a patient in the tumour stage of mycosis fungoides who had not responded to conventional treatment with nitrogen mustard, methotrexate, or grenz rays alone. Besides twelve injections of transfer factor, the patient received X-irradiation, 1 400 r (50 kV 1 mm Al) in all, to three tumours. The combined treatment induced sustained remissions. When that patient died from a coronary infarct 5 years after treatment began, autopsy showed no evidence of mycosis fungoides at all.

Humans↗
PubMed1977

Long-term transfer factor treatment in severe atopic dermatitis.

Transfer factor therapy was applied in three patients with severe atopic dermatitis and given at regular intervals for 1 1/2 years. Clinically, slight improvements were seen, attacks of impetigo ceased and admissions to hospital were not necessary. However, IgE concentrations in serum remained constantly high in all cases and the absolute number of T and B lymphocytes was continuously subnormal despite treatment. The in vitro cellular reactivity to PPD as assayed by a leucocyte migration test was not significantly altered in the patients, although a slight increase was found early on in the therapy. Finally, a serum factor inhibiting leucocyte migration and appearing simultaneously with attacks of impetigo disappeared during treatment. In conclusion, no convincing effect of transfer factor therapy was encountered in immune parameters and no major alterations were found in the status of the patients' atopic dermatitis.

Adult↗
PubMed1977

Studies on the role of the thymus and T cells in the in vivo suppression of delayed hypersensitivity (desensitization): radiosensitivity of the mechanism inducing nonspecific anergy.

Guinea pigs immunized with two or more antigens can have their ability to manifest delayed hypersensitivity (DH) reactions to all these antigens temporarily blocked by the administration of large (mg) amounts of one or more of these antigens 9 days after immunization. This nonspecific anergy is called desensitization. This study presents evidence for the induction of the desensitized state by an active, radiosensitive, immunoregulatory mechanism involving the peripheralization of thymocytes. Desensitization was associated with 1) a marked reduction in thymic weight; 2) an increase in mature T cells in the peripheral blood; 3) decreased responsiveness of the lymphocytes in the spleen to concanavalin-A; and 4) markedly reduced numbers of mono-nuclear cells, basophils, and polymorphs at the skin sites of specific and nonspecific desensitization. Small doses of whole-body irradiation which left DH capacity intact prevented nonspecific desensitization, but did not prevent specific desensitization, suggesting that a radiosensitive cell was involved in the production of anergy.

Animals↗
PubMed1977

PPD and mitogen responsiveness of lymphocytes from patients with atopic dermatitis.

Lymphocytes from twenty-five patients with atopic dermatitis were investigated for their in vitro reactivity to stimulation with tuberculin (PPD), lipopolysaccharide (LPS), phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM). The response to a low dose of Con A was increased, and the reactivity in unstimulated cultures tended to be lower than similar cultures from the control group. Addition of inactivated autologous plasma to the cultures had an inhibitory effect, when the plasma came from patients with high levels of IgE. The patients' in vitro reactivity to PPD in a leucocyte migration test was equal to that found in normal persons and no effect was observed after addition of autologous serum. The mean percentage of E rosette forming cells was significantly reduced in patients with high levels of IgE. The number of EAC rosette forming cells was within normal range. It is hypothesized that the observations could reflect the existence of suppressor mechanisms in patients where the immune system is strongly stimulated.

Adolescent↗
PubMed1976

Studies of smooth-muscle antibodies in acute hepatitis.

Smooth-muscle antibodies (SMA) of the IgG and IgM class in titres of 10 to 80 were demonstrated in 19 of 38 patients with acute hepatitis (50 per cent). No IgA-SMA were detected. IgM-SMA occurred in the beginning of the disease, while IgG-SMA were found both early and late in the course of disease. There was no correlation between the occurrence of SMA and the biochemical liver parameters or the mode of exposure to infection, but IgM-SMA were found more often in the first serum sample obtained from patients without hepatitis-B-associated antigen (HBAg) than in HBAg-positive patients (P1 + P2 = 0.04) and it is suggested that hepatitis virus A more readily than hepatitis virus B can elicit the formation of SMA. The mean PHA-induced lymphocyte-transformation response was significantly lower in hepatitis patients than in the controls (0.02 greater than p greater than 0.01). The lymphocyte-transformation response to a low PHA dose (1 mug per ml) was lower in hepatitis patients without SMA than in those with SMA (0.10 greater than p greater than 0.05). SMA were not found in 28 control persons, and the incidence of tissue antibodies other than SMA did not differ in hepatitis patients and controls.

Acute Disease↗
PubMed1976

Reactivity of lymphocytes from patients with syphilis towards T. pallidum antigen in the leucocyte migration and lymphocyte transformation tests.

The reactivity of lymphocytes to Treponema pallidum antigen was studied before and after treatment in nine patients with early syphilis using a leucocyte migration test and a lymphocyte transformation test. Lymphocyte reactivity was also investigated in six patients treated for syphilis within the last 4 years, and in five untreated patients with a positive result to the T. pallidum immobilization test, but negative results to other serum tests for syphilis antibodies and without any known exposure to risk of infection by syphilis. Ten seronegative patients with different dermatological disorders served as a control group. A significant increase in lymphocyte reactivity to T. pallidum antigen was recorded in both tests in vitro after treatment. There was no difference in lymphocyte reactivity to T. pallidum antigen between the other patients studied and the control group. In early syphilis the spontaneous migration was found to be inhibited before treatment. Tuberculin skin tests were also performed and found to be suppressed in patients with primary and secondary syphilis. No difference in phytohaemagglutinin response was found between any of the groups. Plasma from patients with primary and secondary syphilis was found to change the in vitro reactivity of normal lymphocytes when stimulated with different mitogens.

Antigens, Bacterial↗
PubMed1976

Lymphocyte transformation test with liver-specific protein and phytohaemagglutinin in patients with liver disease.

Lymphocytes from thirty-four untreated patients with various liver diseases were stimulated in a lymphocyte transformation test with liver-specific protein (LSP). Eight of ten patients with chronic active or persistent hepatitis, two of five patients with non-alcoholic cirrhosis and six of nineteen patients with acute hepatitis showed a positive in vitro reactivity to LSP. In a control group of twelve persons without evidence of liver disease, eleven gave a negative response to LSP stimulation, whereas one person showed a positive response. Among fourteen patients with chronic hepatitis or non-alcoholic cirrhosis treated with prednisone at the time of the investigation, only one showed reactivity to LSP stimulation. Three patients in this group had previously had a positive reaction before prednisone was given. There was no statistically significant correlation between the reactivity to LSP stimulation and the presence or absence of hepatitis-associated antigen (HBAg) in serum, or with the biochemical liver parameters. The response to in vitro stimulation with phytohaemagglutinin (PHA) was found to be significantly lower as compared with the control group in eleven patients with alcoholic liver disease and in the patients with acute hepatitis who had HBAg in serum. This decrease in reactivity could apparently not be ascribed to immuno-suppressive factors in the patients' sera.

Acute Disease↗
PubMed1975

In vitro parameters of cell-mediated immune reactions in healthy individuals following immune-stimulation attempts with levamisole.

In vitro parameters of cellular immune reactions were followed by 10 healthy individuals during administration of levamisole. Leucocyte migration tests, lymphocyte transformation tests and ATP-ase activity of peripheral blood lymphocytes were investigated. Levamisole did not influence resting human lymphocytes of the stimulation response of lymphocytes. The metabolic activity of lymphocytes expressed by their ATP-ase activity was not significantly changed after levamisole administration.

Adenosine Triphosphatases↗
PubMed1975

Suppression of tuberculin skin reactivity by prior tuberculin skin testing.

In two consecutive studies, eighteen and forty-one normal subjects were given a standard tuberculin skin test of 1 tuberculin unit (0.02 mug of PPD). Two days later another skin test was given. Readings of the skin reactions showed that subjects exhibiting strongly positive skin reactions in their primary skin tests showed a significantly smaller indurations in their primary skin tests tended to have equal or larger areas of induration after the secondary skin tests. These observations are discussed in relation to the possible existence of regulatory mechanisms of cell-mediated immune reactions.

Adult↗
PubMed1975

Lymphocyte transformation, IgE and T-cells in eczema vaccinatum treated with transfer factor. A case report.

Transfer factor (TF) was given to intensify the cell-mediated immune reactions in an atopic patient with generalized vaccinia. The patient showed marked reactivity of peripheral blood lymphocytes to stimulation with phytohaemagglutinin and pokeweed mitogen, but also in nonstimulated cultures. However, later tests with mitogen stimulation of lymphocytes indicated a defective cellular defence mechanism. The addition of autologous plasma to lymphocyte cultures depressed the reactivity of PHA-stimulation considerably. Initially, the patient also showed a normal T-lymphocyte count in peripheral blood, but six months after her vaccinia, extremely high serum IgE levels and a decreased percentage of T-lymphocytes was observed. Although an evaluation of the clinical effect of transfer factor injection is difficult, it should be noted that the patient's temperature immediately fell to normal, and her general health improved following treatment.

Adolescent↗