In order to evaluate the clinical efficacy of glycosaminoglycan polysulfate (GAGPS) in osteoarthrosis of the knee, a double blind comparative study was carried out at 26 orthopaedic clinics throughout Japan. A total of 120 patients was divided into two groups; one group was treated with 1 mg GAGPS (control group) and the other with 50 mg GAGPS (drug group). Five or more injections (average: 9.3) were given at about weekly intervals (average: 8.2 days). The score derived from the knee scoring scale improved significantly in both groups, either after the 5th and the 10th injections. The score that had improved after the 10th injection in drug group was statistically superior compared to the control (p less than 0.05), however, the difference in the two groups after the 5th injection did not reach a level of any statistical significance. Doctors' assessment of the usefulness of the drug based on the balance of effects and side effects was obtained in 71.2% and 41.1% in drug group and control group, respectively. The difference was statistically significant (p less than 0.01). In conclusion, the authors confirmed that the intraarticular injections of 50 mg GAGPS were useful for osteoarthrosis of the knee although the clinical symptoms were improved only gradually following the injections.

Clinical Trials as Topic↗

PubMedDate not supplied

MR of enchondroma and chondrosarcoma: rings and arcs of Gd-DTPA enhancement.

MR studies of five chondrosarcomas and three enchondromas were performed with intravenous Gd-DTPA administration. All tumors showed enhancement of scalloped margins and curvilinear septa (ring-and-arc pattern) on T1-weighted SE sequences with Gd-DTPA. On radiologic-pathologic correlation, the enhanced areas corresponded to fibrovascular bundles surrounding hyaline cartilage lobules. The rings and arcs of enhancement with Gd-DTPA on MR is a reflection of the lobulated growth pattern of cartilaginous tumors and therefore helpful in differential diagnosis of bone tumors.

Adolescent↗

PubMedDate not supplied

Long-term results of congenital dislocation of the hip treated with the Pavlik harness.

We present the radiographic and clinical results of 158 hips (127 congenital dislocations of the hip, 31 acetabular dysplasias) that were followed-up for > 20 years after the application of the Pavlik harness. The mean Sharp angle of these hips was larger than that of the normal Japanese hip, and the mean center-edge angle was smaller. Thirty hips (19%) were classified as class III, according to Severin's classification. Of 48 unaffected hips in the unilateral cases, 15 hips (31%) had steep acetabula. We believe an intrinsic factor disturbs the normal development of acetabular cartilage in both hips of the patients. Thirty-five hips (22.2%) showed variable grades of deformity of the femoral head, neck, or both. Clinically, most of the treated hips were good in the 3rd decade.

Braces↗

PubMedDate not supplied

Solitary fibrous tumor of the spinal cord. Report of a case with scrape cytology.

BACKGROUND: Solitary fibrous tumor is a rare spindle cell tumor and has been forced at a variety of sites. To the best of our knowledge, only two cases of solitary fibrous tumor arising in the spinal cord have been reported; no cytologic findings were documented. CASE: A 62-year-old male presented with a spinal cord tumor. A scrape smear of the resected tumor revealed naked, spindle-shaped nuclei. Some nuclei were twisted or had long spindles. In the background, abundant, thin and thick collagen fibers were present. Immunohistochemically, the spindle cells were positive for CD34 and negative for S-100 protein and alpha-smooth muscle actin. Histologic diagnosis of the tumor was benign solitary fibrous tumor. CONCLUSION: Our case indicates that solitary fibrous tumor can occur in the spinal cord and should be differentiated from other benign spindle cell tumors, such as meningioma and schwannoma. The key cytologic features of solitary fibrous tumor may be the presence of abundant thin and thick collagen fibers in scrape specimens.

Biomarkers↗

PubMedDate not supplied

Sclerosing lipogranuloma of the scrotum: report of a case with fine needle aspiration biopsy findings.

BACKGROUND: Sclerosing lipogranuloma of the scrotum is a rare granulomatous lesion of the subcutis. To the best of our knowledge, there have been no English-language reports dealing with its cytologic findings. CASE: A fine needle aspiration specimen from a mass in the scrotum in a 62-year-old male showed epithelioid cells, multinucleated giant cells and fibroblasts, which were suggestive of sclerosing lipogranuloma. The diagnosis was confirmed by histology of the resected specimen. CONCLUSION: Fine needle aspiration cytology is useful for the diagnosis of sclerosing lipogranuloma. It is important, however, to interpret the fine needle aspiration cytology specimen in conjunction with the clinical information.

Adipose Tissue↗

PubMedDate not supplied

Macrofollicular variant of papillary thyroid carcinoma. Report of a case with fine needle aspiration biopsy findings.

BACKGROUND: Macrofollicular variant of papillary thyroid carcinoma is defined as a combination of numerous macrofollicles occupying 50% of the tumor and foci of the conventional follicular variant of papillary carcinoma. To the best of our knowledge, there have been no English-language reports on its cytologic findings. CASE: A fine needle aspiration specimen from a mass of the thyroid in a 59-year-old female showed a large collection of dense, inspissated colloid and a few sheets of tumor cells with nuclei characteristic of papillary carcinoma. There were no three-dimensional, branching papillae with fibrovascular cores. CONCLUSION: Although macrofollicular variant of papillary carcinoma is very rare, fine needle aspiration cytology may contribute to its correct diagnosis.

Biopsy, Needle↗

PubMedDate not supplied

Sertoli cell tumor of the testis. Report of a case with imprint cytology findings.

BACKGROUND: Sertoli cell tumor of the testis is a relatively rare neoplasm, and few reports concerning its cytologic findings have been previously documented. CASE: A 41-year-old male had Sertoli cell tumor in the left testis. An imprint smear revealed tumor cells showing a less cohesive or singly dispersed cell pattern. The cytoplasm was faintly stained, and most tumor cells were naked. The nuclei were oval or short and spindle in shape, and some of them showed coffee bean nuclei or nuclear indentation. CONCLUSION: Coffee bean nuclei can be observed in Sertoli cell tumor.

Adult↗

PubMedDate not supplied

Balloon melanoma cells mimicking foamy histiocytes.

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Diagnosis, Differential↗

PubMedDate not supplied

[X-ray epidemiology of ligaments ossifications and disc degeneration of the cervical spine].

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Cervical Vertebrae↗

PubMedDate not supplied

Results of congenital dislocation of the hip joint with open reduction followed up to an age of fifteen years or more.

Forty-three hips (35 patients) with congenital dislocation with open reduction were reviewed. They were under 7 years old at the time of open reduction and over 15 years old at the follow-up. According to Severin's classification, 11 hips were classified as Group I, 7 hips as Group II, and 20 hips as Group III. Avascular necrosis was observed in 20 hips, but no Kalamchi's groups III and IV. The findings were that the younger the patient's age at open reduction, the higher the incidence of avascular necrosis. The cases in which the cartilaginous acetabular floor was demonstrated to be thicker in preoperative arthrography tended to yield unsatisfactory results.

Adolescent↗

PubMedDate not supplied

Socket wear of Charnley low friction arthroplasty: fifteen year follow-up.

Ninety seven hips of primary Charnley low friction arthroplasty in 78 patients were followed up for fifteen to twenty one years. Survival rates calculated by clinical loosening as an end point were 89.8%, and by radiological loosening as an end point were 81.9% for fifteen years. The average rate of socket wear in ninety one of ninety seven hips was 0.11 +/- 0.09 mm per year with an ascending curve. Survival rates at fifteen year follow-up evaluation were 90.4% in the group with a socket wear rate less than 0.20 mm per year and 66.0% in the group with the rate equal to 0.20 mm or more per year. Severe socket wear correlated with radiological loosening of the socket (p<0.001), the presence of a radiolucent line or osteolysis (p<0.0001), and the younger age of the patients less than sixty years old (p<0.05).

Adult↗