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Biomedical subjects

K Teramoto

Publications and source records attributed to K Teramoto.

At least 109 records · Page 6Linked to original sources
PubMed1987

Recovery process of tracheal mucosa of guinea pigs exposed to isopropyl alcohol.

The toxicity of isopropyl alcohol (IPA) on the tracheal mucosa was studied experimentally with special reference to the recovery process of the organ. The results showed that 400 ppm IPA has an acute effect on the mucociliary system in the tracheal mucosa, and that recovery from such degeneration can occur in 2 weeks. When functional and morphological damage was induced by a higher level (5500 ppm) of IPA, recovery did not occur in 2 weeks. The conclusion is that the present allowable level of IPA is reasonable from the viewpoint of the effects of short-term exposure to IPA on the tracheal mucosa. In addition, a higher level of IPA exposure has longer-term effects on the tracheal mucosa, and workers exposed to such a higher level of IPA vapor should be given careful otolaryngological follow-up observations.

1-Propanol↗
PubMed1987

The tarsal tunnel syndrome. Report of two cases of unusual cause.

Since Keck described the tarsal tunnel syndrome (TTS) in 1962, it has been one of the most frequently diagnosed of the entrapment neuropathies. TTS is usually of unknown origin. This is a report of two unusual cases: TTS caused by neurilemmoma in a 33-year-old woman, and TTS caused by subperiosteal ganglion in a 14-year-old girl. The symptoms were relieved, in both instances, with surgical excision.

Adolescent↗
PubMed1986

Degeneration and regeneration of respiratory mucosa of rats after exposure to styrene.

The recovery process of pathological changes in the respiratory mucosa following exposure to styrene were experimentally studied to improve the understanding of the respiratory toxicity of styrene. Thirty male SD rats were exposed to 150 ppm or 1000 ppm of styrene for 4 h a day over 3 weeks (5 days a week). They were killed for examination at 1 day or 12 weeks after completion of the exposure sequence. Bilateral mucosal samples from the nasal septum and the trachea of the animals were examined for ciliary activity and subjected to electron microscopy. Complete functional and morphological recovery of the nasal and tracheal mucosa was observed at the 12th week post-exposure to 150 ppm of styrene. After exposure to 1000 ppm of styrene, almost normal function and morphology of the tracheal mucosa was found at the 12th week post-exposure, but the nasal mucosa continued to show decreased ciliary activity and an affected morphology.

Animals↗
PubMed1986

[Treatment of Ménière's disease. Middle ear infusion with lidocaine and steroid solution].

Before considering the surgical treatment of patients with Ménière disease who would resist to various conservative therapies, including oral drug therapy, the author experimented the inner ear anesthetic therapy or the middle ear infusion therapy with a steroid solution, and each therapeutic result was compared. The results were as follows: 1) The effectiveness of the inner ear anesthetic therapy for vertigo was noted in 42 ears out of the total 47, while the effectiveness of the middle ear steroid infusion therapy for vertigo was found in all treated 21 ears. 2) Although both therapies proved non-effective for hearing disturbance, excluding special cases, the former therapy was found effective for it in 26 ears among 42. 3) For other concomitant symptoms such as the full sensation of ear obturation, head heaviness, and stiff shoulders, both therapies were considerably effective. It was concluded from these results that the first choice of therapy for patients with Ménière disease who should resist to all conservative therapies should be the middle ear steroid infusion therapy at the out-patient clinic, and the second choice would be the inner ear anesthetic therapy, and that both therapies were worth while experimenting before considering surgical treatment.

Dexamethasone↗
PubMed1986

[Classification of optokinetic after-nystagmus and its topographical-diagnostic significance in man].

The existence of optokinetic after-nystagmus (OKAN) has long been known, as far back as the age of Bárány. The term OKAN means nystagmus appearing after first inducing optokinetic nystagmus, and then the optokinetic stimulation is removed. It appears easily with the eyes open in a dark place. There have been various theories about the mechanism of the onset of OKAN. Sakata et al. previously classified the types of OKAN into the following 7 types: 1) The normal type, (2) the directional preponderance type, (3) the disinhibitory type, (4) the inversive type, (5) the inhibitory type, (6) the dysmetric type, (7) the clonic type. In the present study, the authors performed a vestibular equilibrium function inspection, including an OKAN inspection, on about 10,000 patients who visited the Department of Neuro-Otology with complaints of vertigo and equilibrium disturbance. The results of the inspection were classified in accordance with Sakata's method, and the diagnostic contribution of the OKAN inspection was examined. The diagnostic significance of the OKAN inspection is considered as follows: (1) This inspection can detect a very small difference between the left and right of nystagmus in the vestibular-optokinetic system, which difference cannot be detected with OKP inspection giving a rather strong stimulation or with the caloric test giving a non-physiological strong stimulation. (2) This can be a focal localization diagnostic method by the classification by type.

Humans↗
PubMed1986

[Prostacyclin and thromboxane A2 in umbilical circulation in relation to preeclampsia].

In the present study, metabolites of prostacyclin (PGI2) and thromboxane A2 (TxA2), 6-oxoprostaglandin F1 alpha (PGF1 alpha) and thromboxane B2 (TxB2) in the umbilical circulation were determined. Also the baseline and substrate stimulated synthesis and release of these compounds in the umbilical vessels were measured. Umbilical serum 6-oxo-PGF1 alpha levels were significantly higher while no consistent pattern was found for TxB2. The 6-oxo-PGF1 alpha levels in the umbilical artery (UA) were revealed to be significantly lower in preeclamptic patients (PRC) while TxB2 levels were higher. These levels in the umbilical veins (UV) showed no difference. The base line release of 6-oxo-PGF1 alpha and TxB2 from UA and UV showed no statistical difference. With a saturating dose of sodium arachidonate (A . A), both UA and UV tissue showed marked enhancement in the release of the two, in which 6-oxo-PGF1 alpha from UV was significantly higher than that from UA while TxB2 was without statistical difference. Between normal subjects and PRC, there was no difference in the base line release of 6-oxo-PGF1 alpha from UA, while TxB2 was higher in PRC. Substrate A . A did not enhance the release of 6-oxo-PGF1 alpha in the PRC, but the mean TxB2 release tended to increase both in the control and PRC. Present data indicate that the impaired metabolism, especially that of TxA2, and an imbalance between PGI2 and TxA2 may be involved in the development of PRC.

Adult↗
PubMed1985

Recent development of the study on clinical significance of abnormal eye movement.

As a general trend, the diagnosis in medical clinics often depends on laboratory test results. Neurotological diagnosis, however, requires detailed neurological examinations on a patient by a neurotologist. Therefore, there are differing diagnostic skills among physicians, and there is a kind of "man-made flavor" in neurotological diagnostic procedure. In the present study, current development in the knowledge on the clinical diagnostic significance of pathological eye movement during the last 2-3 years is summarized. Acquired pendular wondering eye-movement. Fixation jerks. Spontaneous and transitory eyeball burst or seizure. Vertical rebound nystagmus. Optokinetic vertical ocular dysmetria. Divergence nystagmus. Counterolling, pure rotatory positioning nystagmus. Inversion of optokinetic after-nystagmus (OKAN). Vertical congenital nystagmus and inversion of optokinetic nystagmus (OKN). Treatment of congenital nystagmus. Vertical spontaneous nystagmus to lower eyelid or so-called "downbeat nystagmus." Downbeat nystagmus seen in bilateral labyrinthine dysfunction. The significance of bilateral vestibular lesion, or symmetric lesion in other is emphasized in the present report for reader's reference and criticism. Our experience on the clinical significance of the abnormal eye movement was reported. It is our wish that accumulation of data on important cases along with the results of experimental studies directly connected with clinical medicine may contribute to the progress of our neurotology in the right direction as "neurology of the posterior fossa."

Cerebellar Diseases↗