Studies of aminosugars. 18. Synthesis of amino derivatives of Schardinger alpha-dextrin and raffinose.
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Amino Sugars↗
Biomedical subjects
K Tatsuta
Publications and source records attributed to K Tatsuta.
The total synthesis of kanamycin C.
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Chromatography↗
The total synthesis of kanamycin C.
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Bacteria↗
The synthesis of 6-O-(3-amino-3-deoxy-alpha-D-glucopyranosyl)-2-deoxystreptamine.
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Chemical Phenomena↗
The total synthesis of kanamycin A.
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Bacillus subtilis↗
The total synthesis of kanamycin B.
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Bacillus subtilis↗
Studies of antibiotics and related substances. XXXI. The synthesis of kanamycin-6'-phosphate.
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Kanamycin↗
Studies of antibiotics and related substances. XXXII. Syntheses of neamine and its analogue.
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Anti-Bacterial Agents↗
Synthesis of trehalosamine.
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Anti-Bacterial Agents↗
Synthesis of 4', 6'-O-benzylidene-kanamycin.
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Animals↗
Synthesis of kanamycin-6'-phosphate.
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Animals↗
Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
A potent tyrosine kinase inhibitor, lavendustin A [1], has been isolated from a butyl acetate extract of Streptomyces griseolavendus culture filtrate. It inhibits epidermal growth factor receptor-associated tyrosine kinase with an IC50 of 4.4 ng/ml, which is about 50 times more inhibitory than erbstatin. It does not inhibit protein kinase A or C. Its structure, determined by spectral data and total synthesis, is novel, having a tertiary amine in the center with substituted benzyl and phenyl groups. Lavendustin A competes with ATP and is noncompetitive with the peptide. Its structure-activity relationship is discussed.
Magnetic Resonance Spectroscopy↗