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Biomedical subjects

K Tashiro

Publications and source records attributed to K Tashiro.

At least 469 records · Page 26Linked to original sources
PubMed1988

[A case report of the effective arterial infusion for advanced recurrence breast cancer with 5-FU, ADM, CDDP and OK-432].

A 42-year-old female visited our hospital because of left breast tumor and left arm swelling with severe pain. She had had right radical mastectomy and bilateral oophorectomy at 27 and 29 years of age, respectively. On admission, she had a hard mass, which seemed to be a severe invasion of the chest wall, on her left breast with a severe nipple ulcer. We inserted a catheter operatively through the thyrocervical truncus to the subclavian artery for the arterial infusion therapy. She was administered 250 mg of 5-FU daily, and 10 mg of ADM, 10 mg of CDDP, 10 KE of OK-432, every other week. During 70 days, 10,000 mg of 5-FU, 50 mg of ADM, 50 mg of CDDP and 50 KE of OK-432 were administered. As soon as the breast tumor became smaller, showed some mobility and the nipple ulcer healed, we carried out left mastectomy and axillary lymph node dissection. Pathological findings showed severe degeneration and necrosis of cancer cells. Lymphocytes surrounded necrotic tissue, and there was a follicular pattern of invasion. This phenomenon was considered to result from the promotion of cellular immunological reaction by OK-432.

Adult↗
PubMed1987

Progressive multifocal leucoencephalopathy with magnetic resonance imaging verification and therapeutic trials with interferon.

Progressive multifocal leucoencephalopathy was diagnosed by magnetic resonance imaging (MRI) and brain biopsy in a 44-year-old woman, for whom therapeutic trials with various antiviral agents were made. Despite early diagnosis and treatment, her neurological deterioration and extension of MRI-detectable lesions were not halted for a period of about 8 months. After the introduction of intrathecal beta-interferon therapy, her neurological status and MRI findings became stable and showed minimal improvement. Early diagnosis of this fatal disorder is important and intrathecal interferon therapy should be considered.

Adult↗
PubMed1987

Syringomyelic syndrome: clinical features in 31 cases confirmed by CT myelography or magnetic resonance imaging.

The clinical features of 31 cases of syringomyelic syndrome, confirmed by metrizamide CT myelography (CTM) or magnetic resonance imaging (MRI), were analysed. Bilateral suspended sensory disturbance, previously regarded as a characteristic feature, was encountered in only 2 cases (6.5%). Thirteen patients (41.9%) showed no motor deficits of the upper limbs and 7 patients (22.6%) did not have weakness or atrophy in any of the four extremities. Cervical segmental signs were absent in 7 cases (22.6%) and in 2 (6.5%) signs were only present in the lower limbs. Scoliosis and foot deformity, such as pes cavus or equinovarus, were seen in 17 (54.8%) and 5 cases (16.1%) respectively. These skeletal abnormalities were initial symptoms in some childhood cases. In syringomyelic syndrome, clinical features are variable with many atypical clinical manifestations, apart from the previously recognized characteristic clinical features.

Adolescent↗
PubMed1987

The regulation of tissue eosinophilia. V. Induction of lymphocyte-derived eosinophil chemotactic inhibitory factor production by a macrophage product from complete Freund's adjuvant-treated guinea pigs.

Splenic T lymphocytes of complete Freund's adjuvant (CFA)-treated guinea pigs spontaneously produce a lymphokine, eosinophil-directed chemotactic inhibitory factor (ECIF), which selectively inhibits the chemotactic response of the treated eosinophils to a certain chemotactic lymphokine for eosinophils. In the present paper, induction of spontaneous ECIF production was examined in CFA-treated guinea pigs. Although short-time (3-hr) cultured supernatants of CFA-treated spleen cells exhibited little or no ECIF activity, the supernatants could stimulate normal T lymphocytes to produce and release distinct ECIF activity. The factor with ECIF-releasing activity (ECIF-RF) was produced by splenic adherent cells of CFA-treated animals. ECIF-RF activity was absorbed only by T lymphocytes, suggesting that target cells of ECIF are T lymphocytes. ECIF-RF activity was eluted near cytochrome c (MW 12,500) on a Sephadex G-100 column. It was further found that ECIF-RF was sensitive to heating at 56 degrees C, to enzyme treatment with trypsin and neuraminidase, and to acid and alkaline condition. We thus concluded that ECIF-RF derived from adherent cells of CFA-treated animals may be involved in the suppression of cell-mediated tissue eosinophilia by stimulation of T lymphocytes to produce and release ECIF activity.

Animals↗
PubMed1987

Electron microscopic studies of giant nucleus-like structure formed by lambda DNA introduced into the cytoplasm of Xenopus laevis fertilized eggs and embryos.

When bacteriophage lambda DNA was injected into the cytoplasm of the fertilized egg of Xenopus laevis, giant nucleus-like structures were assembled around the injected DNA. These nucleus-like structures survived during cleavage and were partitioned into blastomeres at the blastula stage. The nucleus-like structures formed in the uncleaved fertilized eggs and the blastula cells were both surrounded by a bilayer nuclear membrane with nuclear pore complexes. The ultrastructural features of the lambda DNA-induced nucleus-like structure were considerably different from those of the normal blastula nucleus: although the nuclear pore complexes appeared to be normal, the 'nucleoplasm' was much too homogeneous as compared with that of the normal nucleus.

Animals↗
PubMed1987

Syphilitic myelitis with its magnetic resonance imaging (MRI) verification and successful treatment.

A 31-year-old man with a 10-day duration of a progressive paraparesis and sensory disturbance was found to have a syphilitic infection which was confirmed by the blood and cerebrospinal fluid (CSF) syphilitic reaction. A discrete and wedge-shaped Gadolinium-DTPA-enhanced lesion on magnetic resonance imaging (MRI) was identified at the level of Th 3/4. The neurologic states and MRI findings improved noticeably after a 16-day course of penicillin with a high dose of prednisolone. Therefore, we want to emphasize the importance and usefulness of MRI in syphilitic myelitis.

Adult↗
PubMed1987

Neuro-Behçet disease and magnetic resonance imaging.

A case of neuro-Behçet disease presenting the signs and symptoms of brain stem involvement was diagnosed with magnetic resonance imaging (MRI), while a CT scan failed to show any abnormalities. These abnormal MRI foci were resolved in accordance with neurologic improvements by means of prednisolone therapy.

Behcet Syndrome↗
PubMed1987

The aetiology of mirror writing: a new hypothesis.

Twenty-eight cases of mirror writing were seen during a period of three and a half years. These consisted of 12 patients with essential tremor, nine with Parkinson's disease, three with spino-cerebellar degeneration and four other cases. There were no cases of hemiparesis, aphasia, apraxia, agnosia or confusion. Fragmentary reversals were excluded from this study. Since essential tremor, Parkinsonian tremor and cerebellar tremor can be abolished by a stereotaxic produce applied to the thalamus, a common neural pathway via the thalamic nuclei may exist in these disorders. The existence is therefore proposed of some neural mechanism that controls the higher cerebral function of writing via the thalamus.

Dominance, Cerebral↗
PubMed1987

Rigidity and dorsiflexion of the neck in progressive supranuclear palsy and the interstitial nucleus of Cajal.

Rigidity and dorsiflexion of the neck are typical signs in progressive supranuclear palsy, but the responsible areas in the brain are unknown. To examine whether bilateral lesions of the interstitial nucleus of Cajal (INC) in the midbrain tegmentum contribute to the signs of patients with progressive supranuclear palsy, we have made bilateral INC lesions in cats and tried to correlate these studies with clinical and pathological data, including our case of progressive supranuclear palsy. Bilateral INC lesioned cats showed dorsiflexion of the neck and impairment of vertical eye movement, similar to progressive supranuclear palsy patients. Analysis of the previous clinical-pathological studies and our case have shown that dorsiflexion of the neck in progressive supranuclear palsy patients was correlated more with INC lesions than lesions of the basal ganglia.

Aged↗
PubMed1987

Skeletal myoclonus in olivopontocerebellar atrophy: treatment with trihexyphenidyl.

We studied two patients with nonfamilial olivopontocerebellar atrophy with skeletal myoclonus. Palatal or skeletal myoclonus is probably not a coincidental finding but another manifestation of the underlying disease. In both cases, the myoclonus was suppressed by administration of trihexyphenidyl, indicating a cholinergic disorder.

Brain↗
PubMed1987

An actograph for small laboratory animals controlled by a personal computer.

This system for measuring behavioral activity and for its analysis by personal computer as the recording device of the actograph was developed in order to measure the drinking activity and the feeding activity of small laboratory animals. According to the results of the measurement on male DBA/2J mice with this actograph, 84.0% of the drinking activity occurred in the dark period while 16.0% in the light period, and the amount of water drunk by the mouse was about 5.7 ml/day under the conditions of a 12 hour light period and 12 hour dark period. Under the same conditions, 79.6% of the feeding activity took place in the dark period and 20.4% in the light period. Also there was a positive correlation between both activities.

Animals↗
PubMed1987

Cervical flexion myelopathy: a "tight dural canal mechanism". Case report.

The authors describe a case of flexion myelopathy due to specific morphological changes of the cervical cord, termed a "tight dural canal mechanism." The patient was an 18-year-old man with progressive weakness and muscle atrophy of the left arm. Neuroradiological examination revealed that the lower cervical cord was compressed during flexion of the cervical spine, but that there was no disc disease or cervical vertebral instability. The cord compression was attributed to a pinching mechanism by the posterior border of the vertebral body and the posterior component of the dura on flexion.

Adolescent↗
PubMed1987

[Glioblastoma multiforme with extracranial metastases without previous surgery: demonstration of extracranial metastases by peroxidase antiperoxidase staining and clinicopathological study].

Spontaneous extracranial metastases of glioblastoma multiforme in the absence of previous surgery have been rarely reported (Table 1). We presented an autopsy case of glioblastoma multiforme which spontaneously metastasized to the lungs, bronchial lymph nodes, liver, kidney, heart and spleen. A 68-year-old man was admitted to the Department of Neurosurgery at our hospital with chief complaints of right sided weakness in July 1984. He was well until November 1983, when he noticed weakness of right lower extremity followed one month later by the weakness in the right arm. He was treated at another hospital under the diagnosis of cerebral infarction, but his right sided weakness gradually progressed. In June 1984, a diagnosis of brain tumor was made by the neurological findings and CT scan, and he was transferred to our hospital for further evaluation and treatment. Neurological examination revealed disorientation, bilateral papilledema, right hemiparesis, right hyperreflexia and right hemisensory disturbance. CT scan revealed abnormal low density area in the left fronto-parietal lobe (Fig. 1) with irregular enhanced lesions on contrast CT scan (Fig. 2). Chest x-ray showed abnormal shadow in the right middle and lower lobe (Fig. 3) and a diagnosis of pulmonary infarction was suspected. The clinical states of this patient took downhill course and he expired on July 13, 1984 by the complication of disseminated intravascular coagulation syndrome. The brain weight was 1400 gr. Dura mater and falx cerebri were tightly adherent to the left parietal lobe (Fig. 4). Primary brain tumor was found in the left fronto-parietal region. The tumor was poorly defined with necrosis and hemorrhage (Fig. 5).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1987

A clinical pathological studies on the human pituitary adenomas by using immuno-histological method.

In total 21 cases of pituitary adenomas were analyzed immunohistologically and electron microscopically. Disturbances of sight and visual field were recognized in almost all cases. Prolactinoma was the most frequent from the immunohistological point of view. Double and triple producers were also found. S100 protein was positive only in 3 cases. S100 positive cells are GFAP negative. This is irrelevant with the characteristics of folliculo-stellate cells ever reported.

Adenoma↗