Search PubMed⌕ Search

Biomedical subjects

K Tanimoto

Publications and source records attributed to K Tanimoto.

At least 325 records · Page 18Linked to original sources
PubMed1978

[Degradation of the parathyroid hormone in the kidney and liver (author's transl)].

The cleavage of the parathyroid hormone has been reported to take place in various peripheral tissues, especially in the kidney and liver. In order to claify the mechanism of such a degradation, bovine PTH (bPTH 1--84) and its synthetic N-terminal peptide (bPTH 1--34) labelled with 125I by the chroramine-T method (125I-bPTH 1--84) and (125I-bPTH 1--34) or labelled with horseradish peroxidase Pox-125I-bPTH 1--84 and Pox 125I-bPTH 1 34) were used to study the disappearance from the blood stream and degradation and retension in the kidney and liver after intravenous injections in male Wiastar rats, weighing approximately 200g. Degradation of PTH was also studied in vitro, using isolated cells and a homogenate of the kidney and liver. PTH labeled with 125I and Pox was more readily degraded by the kidney than PTH labelled with 125I alone, but the opposite was found in the degradation by the liver. Isolated intact kidney cells degraded PTH less efficiently than the homogenate, but the isolated intact liver cells degraded PTH more efficiently than the homogenate, indicating the prominence of an intracellular mechanism of degradation in the kidney and an extracellular mechanism in the liver.

Animals↗
PubMed1978

Werner's syndrome: analysis of 15 cases with a review of the Japanese literature.

Fifteen patients with Werner's syndrome were studied--12 males and 3 females, whose ages ranged from 17 to 59 years. Most of the previously reported clinical characteristics were confirmed, and an additional finding was the frequent occurrence of flat feet and hyperreflexia of the patellar and Achilles tendons. Also noted were an excessive urinary excretion of hyaluronic acid and a decrease in the T-cell subpopulation. The significance of these findings is discussed.

Adolescent↗
PubMed1978

Fc-rosette inhibition by pregnant women's sera and by rabbit anti-beta2-microglobulin.

Some anti-HLA sera showed Fc-rosette inhibitory activity, which had little correlation with type-specific anti-HLA activity. Cytotoxic titers did not correlate with Fc-rosette inhibition rate and these antisera showed considerable inhibition of rosette formation even after absorption of anti-HLA activity with T lymphocytes. These results suggest that some anti-HLA sera contain B-cell-specific inhibitory activity against Fc-receptor like anti-Ia antibody in mice. Rabbit antiserum against human beta2-microglobulin showed specific inhibition of Fc-rosette formation. It was suggested that Fc-receptor or Ia-like antigen in human has a close relation with beta2-microglobulin.

Animals↗
PubMed1978

Close association of human mixed lymphocyte culture antigen, Ia-like antigen and Fc receptor.

The effects of aggregated human IgG, human anti-Ia-like antibody, and anti-beta2-microglobulin on mixed lymphocyte culture (MLC) were studied. Aggregated human IgG inhibited both stimulatory and responding activities in MLC. When Fc-receptor-bearing cells were removed from responding cells, the inhibitory activity of aggregated IgG was markedly reduced. The result suggested that the inhibition of MLC by aggregated IgG is primarily based on the blocking of Fc-receptor-bearing cells contained in the stimulator cells. In addition, the removal of Fc-receptor-bearing cells from stimulatory cells resulted in the loss of MLC response. Anti-Ia-like antibodies contained in anti-HLA sera and B-cell-specific human alloantisera also inhibited stimulatory activities in MLC. Rabbit antiserum against human beta2-microglobulin showed inhibitions of both stimulatory and responding activities. These results suggested the close association of human MLC stimulator site with Fc receptor and Ia-like antigen and also some relation of beta2-microglobulin with MLC reaction.

Antigens↗
PubMed1977

Inhibition of Fc-rosette formation by synovial fluids from patients with rheumatoid arthritis.

Human red cells sensitized with one of the Rh antisera (Ripley) form rosettes (Fc-rosette) with human B lymphocytes and the rosettes are well inhibited by aggregated human IgG. As synovial fluids from patients with rheumatoid arthritis are usually hypocomplementaemic and frequently contain immune complexes, they were used for the inhibition of Fc-rosette formations in this study. The Fc-rosette inhibitory rates were inversely correlated with the levels of CH50 and C4 in the synovial fluids. Fractionation studies of the synovial fluids by ultracentrifugation and Sephadex G200 gel filtration indicated that main inhibitory activities were present in macromolecular fractions. Reduction and alkylation of the synovial fluids resulted in marked reductions of inhibitory activities. The tested synovial fluids did not contain anti-HLA activity as assessed by the microcytotoxicity test. The Fc-rosette inhibitory rates were not correlated with the levels of C3 and immunoglobulins, nor with the activity of rheumatoid factors in the synovial fluids. These results indicate that the Fc-rosette formations are inhibited by the immune complexes contained in the synovial fluids and it was confirmed that the Fc-rosette inhibition test is a simple and sensitive method for the detection of circulating immune complexes.

Arthritis, Rheumatoid↗