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Biomedical subjects

K Tamura

Publications and source records attributed to K Tamura.

At least 631 records · Page 35Linked to original sources
PubMed1995

Incidence of brown dog ticks, Rhipicephalus sanguineus, at a kennel in Okayama Prefecture.

Twenty two adult dogs suffered from tick infestation at a kennel in Okayama Prefecture in the summer of 1994. Four of them had been introduced from U.S.A. Some dogs showed pyoderma, anemia, neutrophilia or eosinophilia. Neither Babesia gibsoni nor Hepatozoon canis was detected on the smear samples of peripheral blood. The ticks detected were morphologically identified as Rhipicephalus sanguineus. This case was a rare incidence of the tick in the other areas of Japan than Okinawa.

Animals↗
PubMed1995

Migration of a subduroperitoneal shunt catheter into the subdural space--case report.

An 82-year-old male with intractable bilateral chronic subdural hematomas was treated by emplacement of bilateral subduroperitoneal shunts on the left in 1990 and on the right in 1991. Chronic subdural hematoma recurred in 1992 due to an unusual migration of a shunt catheter into the subdural space. This migration was probably due to inadequate fixation of the shunt. Shunt replacement and fixation with an anchoring wing has resulted in no further complications for 2 years.

Aged↗
PubMed1995

Pharmacokinetics and tolerance of a new fluoroquinolone antimicrobial drug after single oral doses in healthy volunteers.

1. The pharmacokinetics and tolerance of DV-7751a were investigated in healthy male Caucasian volunteers after single oral doses (100, 200, 400 and 800 mg). 2. DV-7751a was rapidly absorbed in the fasted state. The mean maximum concentration in plasma (Cmax) ranged from 0.27 to 1.98 micrograms/ml for the 100-800-mg dose and the mean time to reach Cmax (tmax) ranged from 1.1 to 1.9 h. The terminal half-life ranged from 8.75 to 10.0 h. A good linear correlation (r = 0.974) was found between doses from 100 to 800 mg and the resulting area under the concentration-time curve (AUC). The plasma protein binding of the drug was in the range of 57-65%. 3. Within 48 h, the cumulative urinary excretion of unchanged drug amounted to 22.0-26.8% of the dose administered. Faecal recovery of the drug up to 72 h after the 400-mg dose was about 12% of the dose given. 4. Adverse events thought to be possibly related to the drug included headache, rash, leg cramp, diarrhoea, abdominal pain, CNS depression and dizziness. DV-7751a, however, was well tolerated with no serious adverse events at any doses and all subjects completed the study. No drug crystals were observed in the urine.

Adult↗
PubMed1995

Atrophic nerve fibers in regions of reduced MIBG uptake in doxorubicin cardiomyopathy.

A myocardial MIBG-SPECT examination was conducted 2 wk after doxorubicin chemotherapy on a 52-yr-old woman without cardiac symptoms. Despite normal 201TI scintigraphy, reduced MIBG uptake was detected in the apical anterior, inferior and lateral segments of the left ventricle. The patient died of congestive heart failure due to doxorubicin-induced cardiomyopathy 10 mo later. At necropsy, the left ventricle was markedly dilated and the apical anterior, inferior and lateral walls were thin, stiff and whitish. Nerve fibers in the apical inferior wall were atrophic and markedly fibrotic where MIBG uptake was most reduced. Nerve fibers in the septum were normal where MIBG uptake had remained normal. The histologic findings correspond with the findings on the MIBG image. MIBG imaging may detect cardiac sympathetic denervation in doxorubicin-induced cardiomyopathy before cardiac symptoms are manifest and cardiac function deteriorates.

3-Iodobenzylguanidine↗
PubMed1995

[A case report of left atrial free-floating ball thrombus in a patient without mitral valve disease].

A 77-year-old man who had a left atrial free-floating ball thrombus without mitral valve disease was operated. His electrocardiogram showed atrial fibrillation. Transesophageal echocardiography showed free-floating mass in dilated left atrium and intact mitral valve. Transesophageal echocardiogram was also useful for intra-operative management. At the operation, the mass proved to be a free-floating ball thrombus in the left atrium and the intact mitral valve was confirmed. The thrombus was removed, but we could not wean the patient from extra-corporeal circulation due to intra-operative myocardial infarction. Autopsy showed left ventricular hypertrophy and the focus of acute myocardial infarction in lateral wall and posterior wall of left ventricle. Furthermore, large organized thrombi were found in aorta and right main pulmonary artery. It was suggested that the patient had abnormal coagulative system or fibrolytic system preoperatively.

Aged↗
PubMed1995

[A recurrence of benign fibrous mesothelioma of the pleura: a case report].

A 64-year-old man who complained of the right chest pain was admitted in our hospital. A mass shadow which revealed the extrapleural sign was shown in the chest X-ray. This patient was performed thoracotomy and a tumor invading to the intercostal muscles was resected. Pathological diagnosis was benign fibrous mesothelioma. About 10 months after this operation, we suspected the local recurrence of the tumor on the chest X-ray. The re-operation was performed, and we resected the recurrent tumor and the 2nd and 3rd ribs. Pathologically the resected tumor was benign fibrous mesothelioma.

Humans↗
PubMed1995

[Thymic lymphoid hyperplasia of myasthenia gravis patients: correlation with clinical features and efficacy of thymectomy].

Thirty nine thymus tissues from myasthenia gravis patients without thymoma who underwent extended thymectomy were evaluated on thymic lymphoid hyperplasia with special emphasis on clinical features and the efficacy of thymectomy. Of 39 patients, 31 were women, but 3 of 7 patients without thymic lymphoid hyperplasia were men. The hyperplastic index of the thymus correlated largely with serum anti-Ach-R antibody titers before surgery. Age, myasthenic type and preoperative duration of the symptoms were almost unrelated to the hyperplastic change in the thymus. The effect of thymectomy was more remarkable in the patients with the hyperplastic thymus than that in them without it, who obtained still no remission after surgery, although the remission rate of them with it reached to 25%. Of 7 patients without the hyperplastic thymus, 4 had no detectable antibody to acetylcholine receptor, whereas in 32 patients with it only 2 were seronegative. This negative immunological factor might make adverse response to thymectomy. Although unfavorable response to thymectomy were observed in the patients without the hyperplastic thymus, most of them were significantly improved through a supplementary treatment with steroid after surgery. Thymectomy was a favorable treatment for myasthenia gravis patients with thymic lymphoid hyperplasia, whereas in them without it the result of thymectomy was unsatisfactory.

Adolescent↗
PubMed1995

[A successful operation for left atrial myxoma and mitral valve regurgitation with giant LA].

A 78-year-old woman was introduced to our clinic, complaining of orthopnea and severe appetite loss, and her performance status was evaluated as NYHA IV. Computed tomogram revealed a myxoma in left atrium (LA) as a low density area and MRI demonstrated a high intensity shadow. Left ventriculogram and color Doppler echocardiogram showed severe mitral valve regurgitation (MR) with giant LA. LA myxoma was completely resected through both LA-tomy and RA-tomy. The LA was plicated according to the method reported by Kawazoe, followed by a mitral valve replacement with SJM 25 mm, and a tricuspid annuloplasty according to the DeVega's method. The postoperative course was uneventful and her performance status improved to NYHA II at discharge. LA myxoma frequently causes secondary MR. In this case, however, the LA myxoma did not affect the function of mitral valve, judging from its size and position. There were a few reports about LA myxoma complicated with primary MR. We also confirmed that a LA plication was very useful for the treatment of giant LA to improve a respiratory failure.

Aged↗
PubMed1995

[Hemichorea-hemiballism associated with nonketotic hyperglycemia and presenting with unilateral hyperintensity of the putamen on MRI T1-weighted images--a case report].

A 74-year-old man was admitted to our hospital with abrupt onset of hemichorea-hemiballism in the left arm and leg. On admission, the blood glucose level was 296 mg/dl, glycosylated hemoglobin Alc was 17.0%, and the serum osmolality was 296 mOsm/l. Urinalysis was negative for ketone bodies, but was strongly positive for glucose. After normalization of the blood glucose level, ballistic movement disappeared, but choreiform movement of the left arm and leg continued for 10 months. Brain CT showed a slight high density of the right putamen, which disappeared on 37th day after the onset. MRI showed high intensity on T1-weighted images and low intensity on T2-weighted images in the right putamen, which disappeared 10 months after the onset. SPECT on the 21th day after the onset showed hyperperfusion in the right putamen. 4 months later, the blood flow slightly reduced in the right putamen. The abnormality in the right putamen was considered to be the cause of his involuntary movements. High intensity in the putamen on T1-weighted MR images in the present case are presumed to have developed following mild ischemia and the reversible deposition of calcium or other material which occurred in association with nonketotic hyperglycemia.

Aged↗
PubMed1995

[Annual number of Pseudomonas aeruginosa isolated inpatients, and antibacterial activity of various antibiotics against P. aeruginosa isolated from clinical specimens of inpatients].

In recent years, isolation rate of methicillin-resistant Staphylococcus aureus (MRSA) has decreased, while the rate of Pseudomonas aeruginosa has increased. This phenomenon may be a result of regulation of use of antibiotics which belongs to the third cephems and extensive preventive measures against hospital acquired infections due to MRSA. Based on our investigation in which we determined MICs of various antibiotics against P. aeruginosa strains isolated from inpatients, the antibacterial activities of cefclidin (CFCL) was superior to those of other antibiotics. The antibacterial activity of CFCL against P. aeruginosa tested was similar to or stronger than that of tobramycin.

Anti-Bacterial Agents↗
PubMed1995

[Yearly changes and geographical distribution of allergic rhinitis morbidity estimated from records of the national health insurance].

The age-adjusted morbidity of allergic rhinitis (AR) in Ibaraki prefecture in May, estimated from data of national health insurance records, increased remarkably from 1980 to 1992 with varying yearly rates of increase. High AR morbidity years coincided with years of high Japanese cedar and cypress pollen counts, and moreover, an estimate equation of the morbidity using as explanatory variables, year and the yearly total count of pollen, accurately estimated AR morbidity. The AR morbidity varied with the size of the municipality. The AR morbidity of the town group and village group were about 80% and about 60% respectively of the city group in 1992. The map of the AR morbidity of each municipality showed that urbanized districts had higher morbidity than areas with cedar forests, which are supposedly sources of the cedar pollen. Continuous increase of morbidity of districts with much cedar forests terminated in 1986. Since then only the fluctuation of the morbidity corresponding to the pollen count was observed. The ratio of the morbidity of the years with much pollen to that of the years with little pollen was mapped. The map showed good agreement with the map of cedar forests. The results obtained above demonstrate the usefulness of the data of the national health insurance records.

Adolescent↗
PubMed1995

[Regional work of the left ventricle before and after CABG].

To evaluate the effects of CABG on regional function of the left ventricular wall, regional work of the left ventricular anterior wall was calculated before and after CABG in 8 patients with multivessel coronary artery disease. In all patients, including CABG for LAD branch, complete revascularization was performed. Regional work of the left ventricular wall was calculated as RW (mJ/cm3) = - integral of sigma d epsilon, where sigma = wall stress and epsilon = regional strain (1n (1/H): H = wall thickness). A major and a minor axis, and anterior wall thickness during cardiac cycle were obtained from the left ventriculogram. Preoperatively, the RW varied widely (from -0.9 to 13.3 mJ/cm3). In 4 cases, the RW decreased and in the other cases, it increased. The RW converged in the tight range (from 2.5 to 6.7 mJ/cm3), postoperatively. These results suggest a uniformalization of the RW in the different regions of the left ventricle was established after the complete revascularization. We conclude that the RW obtained from the analyses of sigma-epsilon relationship is a useful index for evaluating the effects of CABG on the treated region of the left ventricle.

Abdominal Muscles↗