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Biomedical subjects

K Takeuchi

Publications and source records attributed to K Takeuchi.

At least 1,189 records · Page 66Linked to original sources
PubMed1985

Effects of prolonged treatment with compound 48/80 on the gastric mucosa and mast cells in the rat.

Effects of prolonged administration of compound 48/80 (48/80) on the gastric mucosa, serotonin and histamine levels in serum, and mast cells of rats were studied. Daily administration of 48/80 (0.75 mg/kg, i.p.) for 2 or 4 days produced widespread gastric lesions. Further administration of the agent for up to 12 days did not aggravate the lesions which had developed in the early period of administration of the drug. There were only a few visible lesions and numerous healed ones. Almost the same phenomenon was observed with the daily administration of serotonin plus histamine (10 mg/kg each, i.p.) for 2 to 12 days. While 48/80 given for 2 or 4 days increased serotonin and histamine levels in serum, it induced no appreciable increase of these amines after 8 or 12 days of treatment. Serotonin and histamine levels in peritoneal mast cells significantly decreased after the treatment with 48/80 over a 4 day period. The decrease in gastric lesions after prolonged treatment with 48/80 is due to both the depletion of serotonin and histamine from mast cells and an increased resistance of the gastric mucosa with healed lesions.

Animals↗
PubMed1985

Effects of various agents on prednisolone-induced gastric lesions in rats.

We studied the effects of various agents on prednisolone-induced gastric lesions in rats. Gastric lesions were produced by subcutaneous administration of 50 mg/kg of prednisolone once daily for 4 days to non-fasted rats. Daily oral administration of antipeptic, antisecretory agents and 16-dmPGE2 significantly inhibited the lesions. Antacids and PGI2 had little or not effect. These results suggest that the concomitant use of the above agents with steroid therapy to provide protection of the gastric mucosa warrants further attention.

Animals↗
PubMed1985

Role of gastric acid and bile acids in the pathogenesis of compound 48/80-induced gastric lesions in rats.

We studied the effects of various agents, which influence gastric acidity and bile acids, on compound 48/80 (48/80)-induced gastric lesions in rats. 48/80-Induced gastric lesions were produced by repeated intraperitoneal administration of 48/80 at 0.75 mg/kg once daily for 4 days. Test agents were given orally twice daily (30 min before and 9 hr after 48/80 administration) for 4 days. AI(OH)3 and sucralfate at 2000 mg/kg/day, a weak antacid dose, significantly inhibited (about 50-60%) the development of 48/80-induced lesions. Propantheline at 60 mg/kg/day and omeprazole at 60 or 200 mg/kg/day, which reduced gastric secretion for more than 12 hr, also significantly inhibited (about 30-40%) these lesions. Cimetidine at 200 mg/kg/day, which reduced gastric secretion for only 5 hr, had little effect on the lesion formation. Cholestyramine, which is a potent bile acids binding agent, had no effect on 48/80-induced lesions in doses of 600 or 2000 mg/kg/day. These results suggest that gastric acid, but not bile acids, is partly involved in the pathogenesis of 48/80-induced gastric lesions.

Animals↗
PubMed1985

Significance of the measurement of urinary alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase activity in evaluating patients with essential hypertension.

To examine the relationship between the urinary levels of alanine aminopeptidase (AAP) or N-acetyl-beta-D-glucosaminidase (NAG) and the advance of essential hypertension, we measured the urinary levels of these enzymes in 20 normotensive controls, 8 subjects with borderline hypertension and 40 subjects with WHO stage I and stage II essential hypertension. The urinary level of NAG in stage II hypertensives was higher than that in the normotensives, and borderline or stage I hypertensives (p less than 0.01). Systolic blood pressure and the urinary level of NAG was positively correlated in hypertensives (rs = 0.43, p less than 0.01). The urinary level of NAG was correlated inversely with renal blood flow (rs = -0.61, p less than 0.01). The urinary level of AAP in stage II hypertensives was also higher than that in the normotensives (p less than 0.01) or stage I hypertension (p less than 0.01), but the urinary AAP level was not significantly correlated with systolic blood pressure or renal blood flow in hypertension.

Acetylglucosaminidase↗
PubMed1985

[Cardiovascular hemodynamics in patients with essential hypertension during multi-stage exercise].

We investigated cardiovascular hemodynamics in patients with essential hypertension at rest and during exercise. Eight patients with borderline hypertension (Group B), 18 patients with sustained hypertension, and 10 normotensive subjects (Group N) were studied. Patients with sustained hypertension were categorized in two groups; 10 patients without cardiac hypertrophy (Group NH), and eight patients with cardiac hypertrophy (Group HH). To assess the cardiovascular hemodynamics, M-mode echocardiograms, electrocardiograms and carotid pulses were recorded during multistage exercise using a supine bicycle ergometer. Blood pressure was measured simultaneously by the cuff method. At rest, isovolumic relaxation times (IRT) in Groups NH and HH were significantly prolonged as compared with that of Group N. The IRT of Group HH was significantly prolonged as compared with that of Group NH (Group N: 0.06 +/- 0.01 sec, Group B: 0.07 +/- 0.01 sec, Group NH: 0.08 +/- 0.02 sec, Group HH: 0.09 +/- 0.01 sec, respectively). Only the atrial filling fraction of Group HH was significantly increased over that of Group N (Group N: 25.6 +/- 12.1%, Group B; 30.0 +/- 8.1%, Group NH: 27.9 +/- 11.3%, and Group HH: 41.4 +/- 13.1%, respectively). The total peripheral vascular resistance (TPR) in Groups NH and HH was significantly increased over that of Group N (Group N: 1600 +/- 224 dyne/sec/cm-5, Group B: 1704 +/- 465 dyne/sec/cm-5, Group NH: 2370 +/- 608 dyne/sec/cm-5, and Group HH: 3290 +/- 1598 dyne/sec/cm-5, respectively). There was no significant difference in the cardiac index, ejection fraction or heart rate among all groups at rest and during exercise. However, the difference between TPR at rest and TPR at a load of 75 watt (delta TPR) was increased in Groups NH and Group HH over Group N (Group N: 558 +/- 166 dyne/sec/cm-5, Group B: 614 +/- 336 dyne/sec/cm-5, Group NH: 883 +/- 415 dyne/sec/cm-5, and Group HH: 1306 +/- 774 dyne/sec/cm-5, respectively). From these findings, we concluded that there is early diastolic left ventricular dysfunction in Groups NH and HH, and that the degree is more distinct in Group HH. It seems that systolic left ventricular function of both groups is normal during moderate exercise loads, and marked reduction of the TPR in both groups during exercise may be caused by marked peripheral vascular dilatation.

Adult↗
PubMed1985

[Left ventricular function in essential hypertension during isoproterenol infusion].

The left ventricular function of 23 patients with essential hypertension was investigated during infusion of isoproterenol (ISP). These patients consisted of 13 without cardiac hypertrophy (Group NH) and 10 with cardiac hypertrophy (Group HH). Ten normotensive subjects served as normal controls. To assess left ventricular functions, M-mode echocardiograms were recorded at rest and after ISP infusion for 5 minutes (0.005 and 0.01 microgram/kg/min). There were no significant differences in peak negative dD/dt in all groups at rest. But peak negative dD/dt of Group HH significantly decreased after an infusion of 0.005 microgram/kg/min ISP (Group N: 3.43 +/- 0.69, Group NH: 3.15 +/- 0.61, and Group HH: 2.49 +/- 0.48 cm/sec, respectively). The peak negative dD/dt of Group HH was also significantly decreased after a dose of 0.01 microgram/kg/min. Among all patients with hypertension, peak negative dD/dt correlated inversely with left ventricular mass (LVM) after the infusion of ISP (0.005 microgram/kg/min: r = -0.64, p less than 0.001, 0.01 microgram/kg/min: r = -0.68, p less than 0.001). The peak positive dD/dt of Group HH was significantly decreased only when compared with that of Group N at rest (Group N: 3.15 +/- 0.75, Group NH: 3.02 +/- 0.86, and Group HH: 1.92 +/- 0.68 cm/sec, respectively). The difference between the peak positive dD/dt of Group HH and that of Group N was more prominent after the infusion of ISP than at rest. Among all patients with hypertension, the peak positive dD/dt was inversely related to LVM at rest (r = -0.64, p less than 0.002). There was a similar relation between the two indexes after the infusion of ISP. Peak positive dD/dt was related to peak negative dD/dt after a dose of 0.01 microgram/kg/min in Group HH (r = 0.67, p less than 0.05). There was no significant difference in heart rate, change in blood pressure, or total peripheral vascular resistance after the infusion of ISP. It is concluded that diastolic left ventricular dysfunction and latent systolic left ventricular dysfunction are related to increased LVM in Group HH. It seems that after the infusion of ISP severe diastolic left ventricular dysfunction is related to latent systolic left ventricular dysfunction.

Adult↗
PubMed1985

[Evaluation of ACNU alone and combined with tegafur as additions to radiotherapy of the treatment of malignant gliomas--a cooperative clinical trial].

Controlled, prospective, randomized studies were performed to evaluate the effects of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3- (2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) and ACNU plus tegafur as additions to radiotherapy for the treatment of malignant gliomas. In the first trial, 105 patients with glioblastoma or anaplastic astrocytoma were randomly divided into two groups after surgery and received radiotherapy (RT, 40 to 60 Gy to the whole brain), or radiotherapy plus concomitant chemotherapy with ACNU (100 mg/m2 on day 1 and 42). Effects of the treatment were compared in 82 evaluable patients from results of CT scans taken before and one month after the completion of radiotherapy. The regression rates more than 50% of the tumor size were observed in 15.0% of patients treated with RT alone and in 47.6% of patients treated with RT plus ACNU. The difference was statistically significant (p less than 0.005). In the second trial, 87 patients were randomly divided into two groups and received RT plus ACNU, or RT plus combined chemotherapy with ACNU and tegafur (400 mg/m2, daily for 8 weeks). Sixty-nine patients were within the valid study group. The regression rates more than 50% of the tumor size were observed in 34.2% of patients treated with RT plus ACNU: and in 41.2% treated with RT, ACNU plus tegafur. No statistical difference was noted in the response rate between the groups. These results indicate that ACNU is an effective agent in conjunction with radiotherapy for patients with malignant gliomas, and that tegafur does not enhance the effectiveness of ACNU.

Adolescent↗
PubMed1985

[Immunological monitoring of brain tumors--prognosis based on T-lymphocyte subpopulations and skin testing for delayed hypersensitivity].

We have already reported on the usefulness of the phytohemagglutinin (PHA) skin test and the purified protein derivative (PPD) skin test in predicting the prognosis of brain tumor patients. This paper outlines our investigation of T-lymphocyte subpopulations and analysis of their utilization. The cellular immunological states of brain tumor patients were examined by means of PHA and PPD skin tests, the blastogenic response of T-lymphocytes to PHA and the T-lymphocyte subpopulations. Our subjects consisted of 10 cases of glioma (8 astrocytoma, 2 ependymoma), 2 cases of meningioma, one of teratoma, one of hemangioblastoma and 4 of metastatic brain tumor. These were divided into 2 groups: the benign group, which included low grade astrocytoma, meningioma, teratoma and hamangioblstoma, and the malignant group which included malignant glioma and metastatic brain tumor. The T-lymphocytes were counted by monoclonal antibody assay using Ortho-mune T-lymphocyte monoclonal antibody (OK series). We then counted an analysis to determine metastatic brain tumor. The T-lymphocytes were counted by monoclonal antibody assay using Ortho-mune T-lymphocyte monoclonal antibody (OK series). We then conducted an analysis to determine whether or not the T-lymphocyte subpopulations could be of value in the prediction of the possible prognosis of patients. The results were as described below. Ratio of helper/inducer T-lymphocytes (OKT 4 positive cells: Th) to suppressor/cytotoxic T-lymphocytes (OKT 8 positive cells: Ts) were 1.78 +/- 0.18 in the benign group and 1.00 +/- 0.49 in the malignant group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Antenatal assessment of intrauterine growth retardation by ultrasonic fetal biometry and non-stress fetal heart rate testing].

This paper presented the results of ultrasonic measurements and non-stress tests (NST) in 60 light-for-dates (LFD) fetuses. BPD, FFL, mean abdominal diameter (MAD), HC/AC ratio and EFW were used as the parameters and the rates of LFD detection were evaluated. The effects of antenatal therapy for IUGR were assessed by the analyses of normal deviate values of EFW in treated and untreated groups. Qualitative and quantitative analyses of NST findings were presented. As to the detection of LFD, sensitivity values for MAD and EFW were 66.7% and 53.8% respectively; meanwhile both parameters disclosed the same degree of accuracy, as high as 90.0%. EFW values were well correlated to the actual birth weight and the mean estimation error was 147g. No evident increase in the normal deviate value for EFW was noted in any type of therapy. On the other hand, the value decreased in the untreated EPH gestosis group. The incidences of non-reactive and fetal distress patterns for NST in the LFD group were significantly higher than those in the normal control group. In particular, the high rate of mild variable deceleration and dip 0 was characteristic of IUGR. Quantitative analysis of NST also revealed a high rate (38.4%) non-reactive pattern. However, it showed a slight decrease in the amplitude and frequency of LTV.

Female↗
PubMed1985

Red cell deformability in patients with cerebral vasospasm.

Red cell deformability was compared between two groups with and without severe cerebral vasospasm. The results obtained revealed that deformability was decreased in the former as compared to the latter. Pentoxifylline, an ameliorant of microcirculation, also demonstrated the tendency to improve deformability in the case of vasospasm. But improving efficacy for clinical manifestations could not be met only by virtue of such a change while favorable.

Adult↗