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Biomedical subjects

K Takeuchi

Publications and source records attributed to K Takeuchi.

At least 1,045 records · Page 58Linked to original sources
PubMed1988

Substance P involved in mental disorders.

1. This review clarifies the involvement of substance P (SP) in mental disorders, especially schizophrenia. One of the main SP pathways in the brain is the striatonigral pathway. SP applied in the substantia nigra activates the nigro-striatal dopamine system. 2. Administration of antipsychotic drugs decreased SP concentration in the substantia nigra. Some post mortem studies of schizophrenic patients showed elevated SP concentration in some brain regions. Effects of baclofen, a SP antagonist, on schizophrenic patients are uncertain. 3. SP may be involved in the pathophysiology of schizophrenia.

Animals↗
PubMed1988

Mucosal protective action of histamine against gastric lesions induced by HCl in rats: importance of antigastric motor activity mediated by H2-receptors.

The present study was undertaken to investigate the possible mechanism of histamine cytoprotection against 0.6 N HCl-induced gastric lesions in rats by 1) examining functional alterations such as acid secretion, gastric motor activity and mucosal vascular permeability in response to histamine and by 2) comparing the effects of histamine with those of 2-(2-pyridil)-ethylamine (PEA), an H1-agonist and of dimaprit, an H2-agonist. Histamine (3-20 mg/kg s.c.) dose-dependently increased acid secretion, inhibited motor activity and reduced the mucosal lesions in response to 0.6 N HCl. Similar effects were observed dose-dependently with dimaprit (10-40 mg/kg s.c.), but not with PEA (10 mg/kg s.c.). The protective action of both histamine and dimaprit was attenuated significantly by cimetidine (100 mg/kg s.c.) and indomethacin (5 mg/kg s.c.), but not by tripelennamine (10 mg/kg s.c.), which by itself inhibited significantly motor activity and the lesions. Stimulation of acid secretion caused by histamine as well as dimaprit was antagonized significantly by cimetidine, whereas antigastric motor effects of these agents were decreased significantly by both cimetidine and indomethacin. Histamine and PEA increased significantly the vascular permeability as measured by Evans blue, but the increased vascular permeability caused by 0.6 N HCl was reduced markedly by both histamine and dimaprit. These results suggest that the mucosal protective action of histamine may be mediated at least partly by endogenous prostaglandins through stimulation of H2-receptors, and may be associated with the effect on gastric motor activity but not with that on the mucosal vasculature.

Animals↗
PubMed1988

[Flow cytometry DNA analysis of a gastric cancer before and after intra-arterial anticancer chemotherapy--report of a case].

Flow cytometric DNA analysis has been performed on tumor tissue obtained by endoscopic biopsy before and after intraarterial infusion of ADM and 5Fu. The patient was a 74-year-old woman with a gastric cancer with an involvement of a para-aortic and cervical lymph nodes. Histological examination revealed a poorly differentiated adenocarcinoma, and flow cytometric DNA analysis disclosed that the DNA ploidy (DNA index) did not differ before and after intraarterial infusion of ADM and 5Fu. The fraction of the tumor cells in the S + G2.M phase of the cell cycle however, decreased from 56% to 44% with anticancer chemotherapy. A flow cytometric DNA analysis, using biopsied samples of tumor tissue, was found to be a useful tool for monitoring the effect of anti-cancer chemotherapy for solid tumors.

Adenocarcinoma↗
PubMed1988

[Regional left ventricular diastolic dysfunction in patients with apical hypertrophy].

Differences in cardiac function between the apical and the chordal parts of the left ventricle in apical hypertrophy (APH) were investigated by M-mode echocardiography. The subjects consisted of 10 patients with APH (APH Group) and 10 normal controls (N Group). The M-mode echocardiograms of the interventricular septum (IVS) and left ventricular posterior wall (LVPW), both in the apical and chordal parts were simultaneously recorded with the electrocardiogram and phonocardiogram. There were no significant differences in the blood pressures, heart rates, left ventricular end-diastolic internal diameters, and left ventricular end-systolic internal diameters between the APH Group and the N Group. The hypertrophy was localized to the IVS and LVPW of the apical part in the APH Group. In the chordal part, there were no significant differences in the peak negative dD/dt (-dD/dt) and the time to the peak filling rate (TPFR) between the APH Group and N Group. In the apical part, -dD/dt of the APH Group tended to increase compared with that of the N Group. The TPFR of the APH Group was significantly longer than that of the N Group (APH Group: 167 +- 33 msec and N Group: 126 +- 19 msec, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1988

[Detection of left ventricular thrombi after acute myocardial infarction using Ga-67-DFO-DAS-fibrinogen].

Ga-67-DFO-DAS-fibrinogen (Ga-fbg) scintigraphy, a new radiopharmaceutical method, was performed for detecting intraventricular thrombi following acute myocardial infarction in five patients. The thrombi in four of them were detected by two-dimensional echocardiography (2DE) and that in the fifth patient was suspected during magnetic resonance imaging. Imaging of the heart was performed using a scinticamera with a medium energy collimator and multiple views (anterior, LAO 30 degrees, LAO 45 degrees, and lateral) three and four days after the intravenous administration of Ga-fbg. By Ga-fbg scintigraphy, intraventricular thrombi were detected in four patients. The size of the thrombi visualized by Ga-fbg appeared larger than those by 2DE. In one patient examined again after anticoagulant therapy, a thrombus was missed by 2-DE, but it was detected by Ga-fbg, though the radioactivity of the thrombus decreased. We concluded that Ga-fbg scintigraphy is a very simple method and sufficiently useful for detecting active left ventricular thrombi and for monitoring the effect of anticoagulant therapy. It could be more sensitive than 2DE for determining the extent of an active intraventricular thrombus.

Adult↗