Search PubMed⌕ Search

Biomedical subjects

K Takeda

Publications and source records attributed to K Takeda.

At least 1,405 records · Page 78Linked to original sources
PubMed1977

[Hemodynamic and respiratory function following acute spinal cord injury (author's transl)].

Twenty two cases of the cervical and thoracic cord injury were studied to determine hemodynamic and respiratory function within 7 days from the injury. Most patients showed a tendency of bradycardia and hypotension on admission which were more remarkable in the group of lower cervical cord or the upper thoracic cord lesion than the upper cervical cord group. Such a hypotension and bradycardia tended to recover within 7 days. In cervical cord injury, cardiac output remained unchanged, which indicated that initial hypotension was due to decreased total peripheral resistance. Respiratory rate was slightly increased in most patients, but did'nt show any significant difference among the level of the lesion. PaO2 and PaCO2 were within normal range on admission, however PaO2 decreased gradually in 7 days only in cervical cord injury. Increased pulmonary arterial pressure was confirmed during the above hypoxemic period. It suggests that disturbance of neurological control of pulmonary circulation might play a significant role in the respiratory insufficiency of cervical cord injury.

Adolescent↗
PubMed1977

[Experimental studies concerning the hemodynamic and metabolic functions in the canine heart-lung preparation supported by a donor (author's transl)].

In the usual canine heart-lung preparation the coronary blood flow does not remain constant, but increases steadily ; usually, at the moment of the set up of the preparation the coronary blood flow was about 20 ml/min/100 g heart. However, in the course of 2 approximately 3 hours it becomes more than 150 ml/min/100 g heart and the responsiveness of the coronary artery is completely lost under this condition. Concurrently with the increase in the coronary flow, cardiac functions tend to deteriorate. In order to eliminate those experimental disadvantages, we added a donor dog to the heart-lung preparation. It was found that the support by the donor dog resulted in the complete improvement of the above-mentioned deterioration ; the coronary circulation (coronary blood flow and coronary artery and sinus blood oxygen saturation), cardiac function (cardiac output, right atrial pressure, heart rate and others) and cardiac metabolism (myocardial oxygen consumption, mycardial redox potential and others) were kept constant at a favorable state for more than 10 hours.

Animals↗