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Biomedical subjects

K Takeda

Publications and source records attributed to K Takeda.

At least 1,081 records · Page 60Linked to original sources
PubMed1988

Experimental study of vagotomy for prevention of stress ulcer after hepatectomy of cirrhotic livers. Its influence on hepatic regeneration.

We experimentally studied the influence of vagotomy on hepatic regeneration in rats after hepatectomy of cirrhotic livers. In animals that underwent hepatectomy plus vagotomy the reduction in gastric pH was suppressed, but gastric mucosal blood flow was less than that in control animals that received hepatectomy alone. The suppression of 3H-thymidine uptake percentage and thymidine kinase activity after hepatectomy was more marked in animals treated with hepatectomy plus vagotomy than in controls treated with hepatectomy alone. Hepatic DNA level tended to be lower in animals treated with hepatectomy plus vagotomy than in controls. In animals treated with hepatectomy plus vagotomy, the peak level of the mitotic index was lower and the hepatic regeneration rate was evidently suppressed. These results suggest that it is not appropriate to apply vagotomy, during hepatectomy of cirrhotic livers, for the prevention of postoperative stress ulcer because it causes a marked reduction in gastric mucosal blood flow and suppresses hepatic regeneration.

Animals↗
PubMed1988

Effects of salt and DOCA on hypothalamic and baroreflex control of blood pressure.

Cardiovascular and sympathetic nerve responses to electrical stimulation of either the aortic depressor nerve (ADN) or the posterior hypothalamus were recorded from rats treated with salt, DOCA, or DOCA/salt and compared with those from untreated controls. By the 7th day, tail-cuff systolic pressures were significantly elevated in rats treated with salt or DOCA/salt. And by the 21st day, all treated rats (i.e. with salt, DOCA, or DOCA/salt) had elevated pressures together with attenuated ADN responses and augmented hypothalamic responses. After 5 days, DOCA/salt treated rats already had attenuated responses to ADN stimulation and augmented responses to hypothalamic stimulation even though their systolic pressures were still unaltered. These findings suggest that combined treatment with salt and DOCA altered central blood pressure regulation even before hypertension developed.

Animals↗
PubMed1988

Antihypertensive effects and pharmacokinetics of single and consecutive doses of cilazapril in hypertensive patients with normal and impaired renal function.

The antihypertensive effects and pharmacokinetic properties of cilazapril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, were investigated in hypertensive patients with normal renal function (NRF; n = 5) and those with impaired renal function (IRF; n = 7). A 1.25-mg dose of cilazapril was administered orally once a day for 5 or 8 days. Measurement of blood pressure and sampling of blood specimens were done on the first and last days of treatment. Cilazapril induced significant falls in systolic and diastolic blood pressures as early as 1 h after administration. The antihypertensive effects were still present at 24 h postdose. Serum ACE activity was markedly suppressed over 24 h, with the enzyme inhibition greater in the IRF group. Plasma levels of the active diacid in the IRF group were higher than those in the NRF group, with significant differences in the peak levels and areas under the curve (AUC). A significant inverse correlation was found between the creatinine clearance and the AUC for the diacid. Cilazapril was well tolerated by all the patients, and no adverse reactions were observed. These results suggest that cilazapril has a long-lasting action and that it is a useful antihypertensive agent for controlling blood pressure in patients with either NRF or IRF.

Administration, Oral↗
PubMed1988

Morphological characterization of cultured bovine aortic endothelial cells and the effects of atriopeptin II and sodium nitroprusside on cellular and extracellular accumulation of cyclic GMP.

Primary, first and second passaged endothelial cells from bovine aorta were grown in plastic culture dishes or on glass coverslips. The cells were characterized by their monolayer cobblestone appearance at confluence, their immunofluorescent staining for factor VIII-related antigen, their specific uptake of low density lipoprotein and by their ultrastructure. Following stimulation of the cells by atriopeptin II or sodium nitroprusside, both cellular and extracellular cyclic GMP levels were measured. Cellular cyclic GMP content was increased greatly by atriopeptin II in a time-dependent manner while sodium nitroprusside was essentially without effect. Increases in tissue cyclic GMP levels were associated with a time-dependent accumulation of the nucleotide in the extracellular compartment. Zaprinast, a specific inhibitor of cyclic GMP phosphodiesterases, did not significantly affect either basal or atriopeptin II-stimulated increases in cyclic GMP content, nor extracellular accumulation of the nucleotide. It is concluded that the cyclic GMP content of endothelial cells is not solely dependent on degradation by phosphodiesterases but also involves release of cyclic GMP into the extracellular compartment.

Animals↗
PubMed1988

[Atrial septal aneurysm: a report of three cases].

Three cases of isolated atrial septal aneurysm are reported. Case 1: A 66-year-old man visited our hospital for detailed examination and evaluation of premature ventricular contractions and left ventricular hypertrophy previously detected. Echocardiography revealed an atrial septal aneurysm protruding into the left atrium in the early systolic phase and into the right atrium during the mid-systolic to diastolic phase. Subxiphoid M-mode echocardiography showed triphasic movement of the wall of the atrial septal aneurysm toward the left atrium during the end-diastolic to systolic phase, which was enhanced during inspiration. No abnormalities were found by Doppler echocardiography. Cardiac catheterization revealed normal intracardiac pressures and oxygen saturations, but a right arteriogram revealed a defect in the right atrium. Case 2: A five-month-old male infant was referred to our hospital for detailed examination and evaluation of a heart murmur. Echocardiography revealed an atrial septal aneurysm in which a part of the interatrial septum protruded into the right atrium. Case 3: A one-day-old female infant was admitted to our hospital for detailed cardiac examination. Echocardiography revealed that the entire interatrial septum protruded into the right atrium. In Cases 2 and 3 the morphology of the aneurysms did not show cyclic or respiratory change. These two cases had no other abnormalities on echocardiography or Doppler echocardiography. The mechanism of the wall movement in Case 1 seemed to be attributed to differences in pressures between the right and left atria and in properties of the aneurysmal walls. Enhancement of the protrusion of the aneurysmal wall toward the left atrium during inspiration was considered due to inspiratory increase of right atrial pressure.

Aged↗
PubMed1988

[Experimental study on the pathogenesis of pulmonary insufficiency in acute pancreatitis and changes in the pulmonary surfactant].

Serious pulmonary complications are often associated with acute pancreatitis. The destruction of pulmonary surfactant by the action of pancreatic phospholipase A2 (PLA2), together with pulmonary edema, is considered an important etiopathogenic factor of acute respiratory insufficiency. This experimental study was undertaken to elucidate the destruction of pulmonary surfactant in acute pancreatitis using the lung pressure volume curve (P-V curve). Acute hemorrhagic pancreatitis was induced in mongrel dogs by a retrograde injection of Na-taurocholate into the main pancreatic duct. Pulmonary surface tension was measured by P-V curve and the effect of PLA2 on pulmonary surfactant was assessed by the ratio of lysolecithin and lecithin, which are essential components of pulmonary surfactant (Ly/Le) in lung wash. Extravascular lung water volume (Ww/Dw) and blood gases were also measured. The value of Ly/Le and serum PLA2 rose significantly from the 3rd hour. On the contrary, no significant differences were seen on P-V curve until the 12th hour but after 20 hours surface tension increased significantly. Ww/Dw and A-aDO2 increased after 3 and 12 hours, respectively. These findings, the degradation of lecithin and the elevation of surface tension accompanied with an increase of serum PLA2, suggest that pulmonary surfactant is destroyed in severe acute pancreatitis, and that the increased capillary permeability of the lung precedes the deterioration of surface tension as the cause of pulmonary insufficiency.

Acute Disease↗