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Biomedical subjects

K Takebe

Publications and source records attributed to K Takebe.

At least 235 records · Page 13Linked to original sources
PubMed1980

Dose-dependency and reproducibility of the prolactin response to metoclopramide.

Six normal volunteers were tested to ascertain the dose-dependency and reproducibility of the prolactin response to metoclopramide. Furthermore, pretreatments with 1-dopa or cyproheptadine were performed. The same subjects also received intravenously 500 microgram TRH. The oral administration of 5 mg metoclopramide produced a significant rise in prolactin at 60 min and a maximal elevation at 90 min. The intravenous administration of 5 mg metoclopramide produced a significant increment at 15 min and a maximal prolactin level at 30 min. Peak prolactin levels following i.v. administration of the drug were greater than those after oral administration. Intravenous administration of 1 mg of metoclopramide produced a potential increment in plasma prolactin. Maximal prolactin response to 1 mg i.v. metoclopramide was similar to that found with 500 microgram i.v. TRH. Reproducibilities of prolactin response were good in all doses and modes of administration of metoclopramide. Pretreatment with 1-dopa inhibited the metoclopramide-induced prolactin response, but pretreatment with cyproheptadine did not influence the prolactin response to metoclopramide. Metoclopramide is a good and reproducible stimulator of prolactin secretion.

Adult↗
PubMed1979

[A case of extra-intracranial bypass venous graft for giant internal carotid aneurysm (author's transl)].

A male patient, aged 42, (No. 780624) was admitted to the Department of Neurosurgery of Hirosaki University Hospital, complaining recent weight loss, intolerance to cold and visual disturbance of the right eye. Ophthalmological examination revealed the optic atrophy with decreased visual acuity and concentric visual defect of the right eye. Endocrinological examination showed almost general suppression of adenohypophyseal function except abnormal high level resetting of cortisol diurnal rhythm. Radiological examination revealed the accessory middle cerebral artery and giant internal carotid aneurysm of the right side which was displayed by contrast-enhanced CT scan, with the enlarged sella turcica. Good cross filling was seen in left CAG through the anterior communicating artery. Extra-intracranial end to end anastomosis of the right internal carotid artery was performed with long venous graft under general anesthesia with hypothermia and induced hypotension, on Oct. 26 '78. Unroofing of the right optic canal was very useful to preserve the optic nerve, and the body of the giant aneurysm was opened and sutured tightly to reduce its mass effect. Interlacing suture for the anastomosis of the cervical internal carotid artery was employed successfully. The blood flow of the bypass graft, measured as enough volume with square wave flowmeter during the operation, was also confirmed with postoperative angiography. After the episodes of gastrointestinal bleeding, hypotensive attack and hemorrhagic infarction of right frontal base, the postoperative final result was successful and the patient is doing well, 6 months after the operation.

Adult↗
PubMed1978

The effect of prednisolone and metyrapone on FSH release induced by the administration of LRH.

The response of follicle-stimulating hormone (FSH) to a single injection of synthetic LRH was established in 7 and 6 women following an intramuscular dose of 0.2 mg and 0.1 mg. The secretion of FSH was greater in the group injected with 0.2 mg LRH than in the group injected with 0.1 mg. On the other hand, the response of FSH to a single injection of LRH (0.1 mg/subject) was established in 7 men before and after the pretreatment with metyrapone for one dat (4.5 g/subject). Pretreatment with metyrapone provoked a hypersecretion of FSH following a single injection of synthetic LRH. Seven women, 21--48 years of age who were treated with prednisolone for at least 1.5 months were examined for the responsiveness of the anterior pituitary to a single injection of synthetic LRH (0.2 MG). The secretion of FSH was not suppressed and the maximal serum level of FSH was observed 60 min after LRH injection.

17-Hydroxycorticosteroids↗
PubMed1978

Fluctuated changes in the rat hypothalamic content of corticotropin releasing factor around the peak of the circadian rhythm.

It is well known that hypothalamic corticotropin releasing factor (CRF) activity shows a marked circadian rhythm with the peak around 16 o'clock and the minimal level around 8 o'clock, followed by almost parallel changes of plasma corticosterone. But the circadian variations of CRF activity at short intervals (22 or 23 min) around 16 o'clock has not been obvious. In this experiment, we demonstrated fluctuated changes of CRF content in the non-stressed rat hypothalamus with 22 or 23 min intervals around the peak at a quarter past 16 o'clock.

Animals↗
PubMed1978

Oral administration of chymotrypsin labile peptide for a new test of exocrine pancreatic function (PET) in comparison and pancreozymin-secretin test.

A new test using N-benzoyl-L-tyrosyl-p-aminobenzoic acid (N-BT-PABA) for an evaluation of exocrine pancreatic function was compared with a pancreozymin-secretin test in 38 subjects. Urinary recovery of PABA, which is absorbed from the intestine and conjugated in the liver after an oral administration of N-BT-PABA, depends mainly on chymotrypsin activity. The recovery rate of PABA in urine decreases in chronic pancreatitis, in which chymotrypsin activity in the duodenal juice is disturbed. The recovery rate of PABA in calcifying chronic pancreatitis was 40.2 +/- 15% and significantly less than 81.2 +/- 7.4% in normal subjects (P less than 0.01). The amount of PABA in urine during eight hours was correlated with parameters of volume output- bicarbonate concentration and amylase output stimulated by injections of pancreozymin and secretin (P-S test). The new test using N-BT-PABA is useful for the evaluation of exocrine pancreatic function in general practice.

4-Aminobenzoic Acid↗