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Biomedical subjects

K Takada

Publications and source records attributed to K Takada.

At least 631 records · Page 35Linked to original sources
PubMed1989

Associations between jaw-opening muscle activity and craniofacial morphology.

The purpose of this study was to investigate the relationship between jaw-opening muscle activity and craniofacial morphology in a sample of 64 adults with skeletal Class I malocclusions. EMG recordings from the inferior head of the right lateral pterygoid and the anterior belly of the right digastric muscle were analyzed together with mandibular displacement data sampled simultaneously with a kinesiograph. Incisor separation at the rest position and the threshold mandibular rotation position which corresponded to the onset of muscle activity in response to a graduated mandibular rotation were identified. Incisor separation was converted to a mandibular angle on lateral cephalograms. Anatomic points were digitized and sixteen traditional cephalometric variables were determined. The rest position angle did not correlate with the threshold angle for the anterior belly of the digastric muscle, but a significant correlation was identified with the inferior head of the lateral pterygoid muscle. One canonical correlation (r = 0.741; p less than 0.01) was identified between the mandibular rotation and dentoskeletal variables. Negative loadings with lateral pterygoid muscle threshold and rest position angles were obtained. The corresponding dentoskeletal variables had a positive loading with mandibular plane angle, total and lower anterior face height and gonial angle and a negative loading with lower posterior face height. The results suggest a possible relationship between lateral pterygoid muscle activity at two specific mandibular positions and the resultant form and posture of the mandible.

Cephalometry↗
PubMed1989

[T cell subsets as a prognostic factor in the chronic phase of chronic myelogenous leukemia].

A relationship between the survival time and T cell subsets in the chronic phase of chronic myelogenous leukemia (CML) studied by the method using monoclonal antibodies. No statistic difference between normal and CML was recognized in the rate of pan-T cell. The high T-Helper/Suppressor ratio (TH/TS) was revealed in the cases of the long survival time for more than six years.

Humans↗
PubMed1989

[Adrenal arterial embolization and radiotherapy of a case with metastatic adrenal tumor and its tumor thrombus in inferior vena cava from hepatocellular carcinoma].

Right adrenal arterial embolization and radiotherapy were performed in a patient to treat the metastatic tumor and its tumor thrombus in inferior vena cava from hepatocellular carcinoma. This case developed no complication following the embolization and radiotherapy. This therapy necrosed the metastatic tumor and made inferior vena cava recanalization. Adrenal arterial embolization and radiotherapy were effective treatment for the metastatic adrenal tumor and its tumor thrombus.

Adrenal Gland Neoplasms↗
PubMed1989

[Combined long-term toxicity/carcinogenicity test of alpha-bromocinnamic aldehyde (BCA) applied to female mouse skin].

Bromocinnamic aldehyde (BCA), an antibacterial/antifungal agent, was tested for its chronic toxicity/carcinogenicity in female Slc:ddY mice. The animals received 0.25%, 1.0% and 4.0% of BCA dissolved in olive oil applied to the shaved back skin area twice a week for 79 weeks. The control group received olive oil alone under similar conditions. In addition to these animals, 5 animals in each group were killed at 6 and 12 months for investigation of the time-related toxic effect of BCA. A slight inhibition of body weight increase and a slight decrease in the survival rate were seen in the 4.0% BCA-treated group. No significant changes were observed in hematological parameters at 6, 12 and 18 months. In chemical biochemistry determination in the blood at 6 and 12 months, a significant decrease in non-esterified fatty acid and phospholipid values was observed in the experimental groups. Histopathologically, necrosis, scabbing, cell infiltration and thickening of the epidermis were noted at the site of application in the 4.0% BCA group. Moreover, extramedullary hematopoiesis and amyloid degeneration were detected in the spleen, while the incidence of adenomas in the lung decreased with a dose-response. These changes seemed to be the result of a non-specific inflammatory reaction to the irritation effects of the agent on the skin. No significant differences in the incidence of tumors were found between the control and experimental groups, not only at the site of application but also in other organs, although lung adenomas decreased dose-dependently in all treated groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Aldehydes↗
PubMed1989

[Acute and subacute toxicity studies of tris (1,3-dichloro-2-propyl) phosphate on mice].

Slc/ddY mice (10 male, 10 female per group) were given a single p.o. intubation of tris (1,3-dichloro-2-propyl) phosphate (TDCPP) in olive oil and were observed for 14 days. LD50 values of male and female mice were 2.67 (2.52 approximately 2.83) and 2.25 2.25 (2.12 approximately 2.39) g/kg, respectively. The animals revealed ataxic gait, hyperactivity, and convulsion. Slc/ddY mice (12 male, 12 female er group) were administered diet containing 1.33, 0.42, 0.13, 0.04, and 0.01% of TDCPP for 3 months. Male and female mice of the 1.33% group showed emaciation, rough hair, and tremor; and all animals died within one month. Hematological studies showed slight anemia in males of the 0.42% group and females of the 0.42% and 0.13% groups. They also exhibited a tendency to increase ALP and GPT levels. The animals of the 0.42%, 0.13% and 0.04% groups exhibited tendency to increase liver weights and kidney weights in both sexes. Histopathologically, very slight focal necrosis was recognized in the liver in only 2 females of the 0.42% group. The NOEL under this condition is 0.01% in the diet of tris (1,3-dichloro-2-propyl) phosphate (male: 13.2 mg/kg/day, female: 15.3 mg/kg/day).

Administration, Oral↗
PubMed1989

Comparison of the toxicity of p-dichlorobenzene (p-DCB) administered to male F344 rats orally or by the inhalation route.

The organ distribution and toxicity of p-DCB were compared in rats after either inhalation or oral administration. Male F344 rats were exposed to 500 or 125 ppm for 24 hr in a whole body inhalation chamber (H and L groups) or received a single dose of 300 mg/kg by gavage (PO group). The concentrations of p-DCB in the serum, liver, kidney and fatty tissues were measured by gas chromatography at intervals during and up to 24 hr after the treatment. Peak serum values for the L and H groups were lower than in the PO animals, but the organ/serum distribution ratios of p-DCB tended to be higher, in some cases markedly, in rats receiving the inhalation treatment. Significant increases in the levels of blood urea nitrogen, hepatic glutamic oxaloacetic transaminase and glutamic pyruvate transaminase and significant decreases in the levels of serum total cholesterol were observed only in the inhalation groups. Microscopically, the appearance of numerous eosinophilic droplets, together with swelling and desquamation of the proximal tubular epithelium of the kidney was especially noteworthy in H and L p-DCB treated groups. Thus, both biochemical and histopathological abnormalities induced by p-DCB were more pronounced in rats administered the compound by the inhalation route.

Administration, Inhalation↗
PubMed1989

[Intrahepatic portal vein aneurysm: report of two cases].

We present two cases of intrahepatic portal vein aneurysm. The lesions were seen as low density mass on precontrast CT, hypoechoic mass with connecting vascular structures on ultrasonogram and dilatated branch of portal vein on MRI. Definite diagnosis were obtained by arteriogram. Only 15 cases of portal vein aneurysm were reported in Japan up to now in the literature.

Aged↗
PubMed1989

Diagnosis of thyroid mass due to intravenous digital subtraction angiography--does it play an important part in diagnosis of thyroid mass?

33 patients with thyroid mass were studied by intravenous digital subtraction angiography (IV-DSA), thyroid scintigraphy (TS), ultrasonography (US), and computed tomography (CT). The detective rate of lesion by each diagnostic imaging was as follows: IV-DSA 71%, TS 70%, US 94%, and CT 76%. US was the most excellent and most sensitive diagnostic imaging of both benign and malignant lesions. As regards the thyroid cancer by IV-DSA, malignant findings were heterogeneity, an irregular contour, and an unclear contour of tumor stain. Specific diagnostic rate of each imagings was as follows: IV-DSA 88%, TS 100%, US 86%, and CT 75%. US was not so good imaging of a specific diagnosis for the thyroid mass. As regards the thyroid mass, influence of the common carotid artery and the internal jugular vein were investigated by the degree of compression of both vessels on IV-DSA. However IV-DSA could not reveal tumor invasion to these vessels. We learned present the limit of diagnosis of the thyroid mass due to IV-DSA, because IV-DSA was unable to reveal to us exactly information of both a sensitive and a specific diagnosis. We, however, think that IV-DSA is a useful diagnostic imaging as a mapping study which reveals a coronal image of a relationship between the thyroid mass and the common carotid artery and/or the internal jugular vein in surgery.

Adult↗
PubMed1989

Gingival fibroblasts and tissues attachment to curetted cementum surface in periodontally involved teeth.

We examined whether or not gingival fibroblasts attach to curetted cementum surface in periodontally involved teeth. For in vitro experiment, superficial cementum in periodontally involved human teeth was curetted and cut into 3 X 3 mm fragments, put into a plastic plate and mixed with fibroblasts for 1 to 3 days. Numerous fibroblasts attached to the curetted cementum surfaces, while only a few fibroblasts could attach to the diseased cementum. For in vivo experiment, experimental periodontitis was induced in monkeys by leaving a resin plate in artificially created marginal bone crest for 3 months. In the flap surgery, only superficial cementum was curetted. Two- and 4-month biopsy specimens disclosed that the regenerated gingival tissues attached well to the curetted cementum surface. Both in vivo and in vitro results indicated subjacent cementum in periodontally involved teeth could be a suitable surface for fibrous attachment.

Animals↗
PubMed1989

In vitro interaction between gingival fibroblasts and various root surfaces.

The objective of the present in vitro study was to examine the effect of various root surface treatments on the initial attachment of gingival fibroblasts. Cultured fibroblasts were well spread and attached to demineralized dentin with citric acid, superficially curetted cementum, and root surface with periodontal ligament, while those on the planed dentin showed a poorly spread appearance. The first three root surfaces exhibited rough and irregular surface appearances with a well-developed filopodia and the latter root surface exhibited a smooth appearance, suggesting the texture of the root surface is closely associated with cell attachment. Interiorized collagen fibrils and numerous cytoplasmic vesicles were seen along the cell membrane of fibroblasts facing the root surfaces of the planed dentin, demineralized dentin, and superficially curetted cementum. Thus even the artificially exposed tooth surface with citric acid may be subjected to further alteration by fibroblasts.

Animals↗
PubMed1989

Two cases of venous aneurysm of the intrahepatic portal vein branch: MR demonstration.

Two cases are reported of congenital intrahepatic portal vein aneurysm in women who had chronic hepatitis. Ultrasound (US) and computed tomography (CT) investigations revealed vascular communication between intrahepatic portal vein and venous aneurysms in both cases. These portal vein aneurysms were fusiform in shape and two and one centimeter in diameter in each case. On angiography portal-hepatic venous shunt was observed in one case. The MR image of two cases were presented. We believe this is the first report of MR image of portal vein aneurysm.

Aged↗