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Biomedical subjects

K Taguchi

Publications and source records attributed to K Taguchi.

At least 307 records · Page 17Linked to original sources
PubMed1983

Instant shift from continuous flow assistance to paracorporeal diaphragm type pulsatile assistance.

Experiments were conducted implementing a special technique for shifting instantaneously from continuous flow to pulsatile flow assistance by using the assistant heart and obtaining the following results: Within only a few minutes, the shift could easily be made from one type of flow assistance to another on calves with normal hearts. In the 10 calves in which ventricular failure was produced, this instantaneous shift from continuous to pulsatile flow assistance brought about remarkable improvements in their hemodynamics. At the occurrence ventricular fibrillation in 6 of the calves, the return to sinus rhythm was possible with aid of this shift mechanism.

Acute Disease↗
PubMed1983

[Clinical statistics on outpatients, inpatients and operations at the Department of Urology, Hyogo College of Medicine, in 1982].

Statistical studies on 2,040 new outpatients, 575 inpatients and 570 operative procedures at our department in 1982 revealed the following. The most frequent diseases among the outpatients were urogenital infections followed by anomalies and tumors. Over half of the inpatients were pediatric patients and the major diseases among inpatients were hypospadias, vesicoureteral reflux, urolithiasis, congenital urethral stenosis and undescended testis. A total of 570 operations were performed on 531 patients, and the major five operations were hypospadias repair (79), optic internal urethrotomy (71), TUR-P (49), ureterocystoneostomy (33) and orchidopexy (32).

Adolescent↗
PubMed1983

[Case report of large endometrial stromal sarcoma].

A 56-year-old-married woman, gravida 3, para 2, was admitted with chief complaints of atypical genital bleeding, large abdominal and genital tumors, dysuria and abdominal pain. All laboratory examinations were noncontributory. Abdominal total hysterectomy with bilateral salpingo-oophorectomy was performed. The tumor measured 30 X 11 X 8 cm and weighed 1,600 g. It showed polypoid growth and most of the tumor was necrotic. The tumor cells resembled endometrial cells and 20 mitotic figures per 10 high-power fields were noted. Ten months postoperatively, the patient was in good condition with use of PSK.

Female↗
PubMed1982

Deterioration of Ebstein disease after closure of atrial septal defect.

We treated a 7-year-old girl in whom the clinical evidence of Ebstein disease was manifest after a surgical closure of an atrial septal defect. This manifestation, which was not evident either in the preoperative catheterization studies or during operative investigation of closure of the atrial septal defect, required further hemodynamic and angiographic evaluation. Tricuspid valve replacement with Hall-Kaster prostheses was carried out.

Cardiac Catheterization↗
PubMed1982

Influences on drugs on evoked potentials in the cat cerebellum: I. Effects of CNS depressants and stimulants on the cerebellar afferent pathways.

The effects of drugs on the potentials evoked by electrical stimulation on the sensorimotor area (SMA), nucleus reticularis tegmenti pontis (PTRN), nucleus reticularis lateralis (LRN), nucleus olivaris inferior (ION), or superficial radial nerve (SR) were investigated in cat cerebellar cortices. Pentobarbital-Na decreased the amplitude of the potentials evoked by all stimulations at every recording site. Pentobarbital-Na remarkably decreased the SMA- or PTRN-stimulation induced evoked potentials in the anterior lobe. Chlorpromazine decreased the amplitude of the potentials evoked by SMA stimulation on the anterior lobe and ipsilateral crus l, and the drug increased it on the posterior lobe and contralateral crus l. With precerebellar nuclei stimulations, chlorpromazine decreased the amplitude of the evoked potentials in cerebellar cortices, whereas SR stimulation-evoked potentials were remarkably increased in amplitude. Meprobamate increased the amplitude of the potentials evoked by precerebellar nuclei or SR stimulation at an early stage and then decreased it. Caffeine, picrotoxin, and strychnine remarkably increased the amplitude of the potentials in cerebellar cortices evoked by all stimulations. Strychnine in particular significantly increased the amplitude of the potentials evoked by SR stimulation. These results strongly indicate that CNS depressants and stimulants affect the cerebellar afferent pathways, probably in an indirect manner.

Animals↗
PubMed1982

Inhibitory effects of aryl trans-4-(aminomethyl)cyclohexanecarboxylate and aryl trans-4-(guanidinomethyl)cyclohexanecarboxylate on serine proteases, and their antiallergic effects.

Since serine protease in involved in histamine release from mast cells, we attempted to prepare new protease inhibitors, trans-4-(guanidinomethyl)cyclohexanecarboxylic acid (GmcHX-CO2H) esters, and examined their inhibitory effects on typical serine proteases and on histamine release induced by compound 48/80. We compared their effects with those of trans-4-(aminomethyl)cyclohexanecarboxylic acid (AmcHx-CO2H) esters. AmcHxCO2H and GmcHxCO2H esters inhibited the esterolytic activity of trypsin, but GmcHx-CO2H esters had little or no inhibitory effect on caseinolytic activity whereas AmcHxCO2H esters strongly inhibited the latter. AmcHCO2H esters strongly inhibited plasmin but had no effect on chymotrypsin. GmcHxCO2H esters strongly inhibited the esterolytic activity of chymotrypsin, but had no effect on chymotrypsin-induced caseinolysis. Both GmcHxCO2H an AmcHxCO2H esters inhibited urokinase. Of the esters of AmcHxCO2H and GmcHxCO2H tested, only GmcHxCO2H p-tert-butylphenyl ester (GmcHxCOOPhBut) at low concentration (27 microM) strongly inhibited histamine release from rat mast cells induced by compound 48/80. GmcHxCOOPhBut was effective in preventing active systemic anaphylaxis and passively sensitized guinea pigs. Its effectiveness in preventing anaphylactic phenomena might be due to its strong inhibitory effects on histamine release from mast cells.

Acetylcholine↗
PubMed1982

Follow-up study of giant cell tumor of bone.

Forty-two patients with giant-cell tumor of bone were treated by various surgical procedures. Local recurrence and pulmonary metastasis were surveyed with respect to the operation performed. A high incidence of local recurrence was observed in the group who underwent curettage for the bone lesion. Four cases had pulmonary metastasis and three died of tumor. Adequate surgical treatment of giant-cell tumors of bone needs at least en bloc resection of the bone lesion with reconstruction. Although the microscopic findings in our malignant cases differed somewhat from benign ones, it was very difficult to predict later malignant change from the histological features of the initial stage.

Adult↗
PubMed1981

Actions of desoxynupharidine hydrochloride in the central nervous system of experimental animals (I).

The effects of desoxynupharidine hydrochloride (DN) as the extractive component of the Nuphar japonicum DC on the central nervous system were studied. In the acute cats, DN (1-3 mg/kg, i.v.) produced 8-10 Hz waves in the hypothalamus lateralis and amygdala, and the hippocampal arousal wave gave way to the irregular high amplitude slow waves. In the midbrain reticular formation, nucl. reticularis and cortex, 12-13 Hz waves and high amplitude slow waves increased. A sleep-like pattern with spindle burst-like waves formed the general pattern of all EEGs. These spontaneous EEG activities were significantly inhibited by epinephrine hydrochloride and were potentiated by tolazoline hydrochloride and dibenamine hydrochloride etc. The above EEG changes were obtained even in the spinal cats. DN depressed the EEG arousal response produced by high frequency stimulation of the sciatic nerve and increased the threshold of stimulation. In the chronic cats, DN (1 mg/kg, i.v.) produced spindle burst-like waves of 12-14 Hz in the cortex and sedation concomitantly. These findings suggest that DN has an inhibitory effect on the central nervous system and that adrenergic neurons are probably involved.

Alkaloids↗
PubMed1981

Actions of desoxynupharidine hydrochloride in the central nervous system of cats (II).

Effects of desoxynupharidine hydrochloride (DN) on the central nervous system of cats were studied using electric physiological techniques. With regard to the EEG arousal responses, DN (1-3 mg/kg, i.v.) inhibited the responses induced by midbrain reticular formation and posterior hypothalamus (P-Hypo) stimulation. The threshold voltage of stimulation was elevated. DN decreases the amplitude of the augmenting response and the recruiting response induced by the stimulation of specific and non-specific pathways in the thalamus. As to the evoked potentials in the somatosensory area I, DN decreased the amplitude of the fast and late components. This compound slightly inhibited the monosynaptic and polysynaptic reflexes, in the spinal cats. With regard to autonomic responses on stimulation of the P-Hypo, DN decreased contractions in the nictitating membrane, the hypertensive action and the galvanic skin response. Our findings indicate that the inhibitory effects of DN on the central nervous system may be related to the brainstem reticular formation and the hypothalamus activating system, the non-specific pathway, the specific pathway and the limbic system etc., and may involve the central anti-adrenergic actions.

Animals↗