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Biomedical subjects

K T Chen

Publications and source records attributed to K T Chen.

At least 109 records · Page 6Linked to original sources
PubMed1991

An analysis of traffic injuries in Taiwan in relation to alcohol use and economic loss.

Breath alcohol analysis of 449 patients with motor vehicle injuries attending the emergency department of a Taiwan urban general hospital during a 10-week period showed that 19.2 per cent had breath alcohol concentration (BAC greater than 0.002 per cent and 8.5 per cent greater than or equal to 0.05 per cent). Injured males were more likely to have BAC greater than or equal to 0.05 per cent than women (11 per cent vs 0 per cent). Injuries resulting from alcohol-associated collisions were about 6.7 times more likely to occur between 1800 and 0600 than at other time periods. A telephone survey after hospital discharge showed that the risk factors of alcohol use, speed at time of collision and type and site of collision were significantly associated with degree of economic loss resulting from the accidents. Logistic regression analysis showed that the odds of high economic loss associated with BAC greater than 0.002 per cent were three times greater than for persons in whom no alcohol was detected. This is the first study in Taiwan to use breath alcohol analysis in assessing the effect of alcohol consumption on motor vehicle injuries. The results show that alcohol use is an important cause of motor vehicle injuries. Preventive measures such as strict legal control of drunk driving and limitation of the hours that drinking places can stay open at night are recommended to reduce the damage caused by this severe public health problem.

Accidents, Traffic↗
PubMed1991

Appendiceal carcinoma masquerading as primary bladder carcinoma.

We report 2 cases of appendiceal adenocarcinoma invading the bladder. Both tumors masqueraded as primary bladder carcinomas. Cystoscopic biopsies obtained adenocarcinomatous tissue and the secondary nature of the bladder lesion became apparent at laparotomy in both cases. One patient was treated with surgical resection of the appendix, the adjacent cecal wall and the bladder wall, and postoperative irradiation. She was well 10 years later. The other patient was treated with right colectomy and segmental bladder resection. She died of diffuse peritoneal recurrence 6 years later.

Adenocarcinoma, Mucinous↗
PubMed1991

Angiosarcoma in postsurgical lymphedema. An unusual occurrence in a man.

A 63-year-old man underwent partial left axillary node dissection for metastatic melanoma of unknown primary. Lymphedema of his left upper extremity developed after surgery. Eight years later, extensive cutaneous angiosarcoma developed in the edematous limb. The occurrence of cutaneous angiosarcoma in postsurgical lymphedema is extremely rare in men; to our knowledge, our case is the fifth such case thus far reported.

Arm↗
PubMed1991

Factors affecting local or regional recurrence in breast cancer.

Between 1975 and 1989, 535 patients with infiltrating ductal carcinoma of the breast in various clinical stages were treated by modified radical mastectomy and axillary node clearance, followed by chemotherapy, endocrine therapy or radiotherapy. Median follow-up was 3 years (5 months to 15 years). Fifty-eight local or regional recurrences occurred. The 5-year and 10-year actuarial risks of breast recurrences were 14% +/- 2% and 23% +/- 4%, respectively. Using multivariate analysis with the Cox regression model, the most important multivariate-adjusted independent contributing factors to local or regional breast recurrences were age less than or equal to 40 (p less than 10(-4), relative risk = 2.94), positive lymph nodes greater than 3 (p less than 10(-3), relative risk = 2.57), and multicentricity (p = 0.044, relative risk = 2.73). The overall 5-year survival rate of recurrent patients was 64 +/- 7%, and was significantly worse when breast recurrence occurred in the first 18 months after operation. The multivariate-adjusted relative risk of death for early recurrence was 4.35 (p = 0.04). The unadjusted 5-year survival rate for early recurrence was 58% +/- 1%, and 85% +/- 8% for late recurrence. This study confirms the relationship between young age and low breast control rates. It emphasizes the adverse prognosis of early breast recurrences as compared to the relatively favorable outcome of late recurrences.

Adult↗
PubMed1991

Studies on the photochemical and photocytotoxic properties of the new PDT photosensitizer aluminum sulfonated phthalocyanine.

The properties of photosensitization of sulfonated aluminum phthalocyanine (ALSPC), a new photosensitizer of potential use in cancer photodynamic therapy (PDT) was studied on both the molecular and cellular levels. The mechanism of ALSPC photosensitization on the molecular level was investigated by testing its efficiency of singlet oxygen (1O2) production, using the method of tryptophan degradation and that of ESR spectroscopy and observing the enhancing effect of D2O and the quenching effect of NaN3. Results of all these experiments confirmed the important role of the Type II or 1O2 mechanism in ALSPC photosensitization. In our in-vitro experiments, ALSPC's incorporation into cells and its photocytotoxic effect were investigated on a human liver cancer cell line. The cell incorporation was illustrated by the laser-excited fluorescence spectra emitted both from cell homogenate and cell monolayers incubated with ALSPC aqueous solution. The position of fluorescence peak observed, implied that ALSPC exists in the cells mainly as monomers. The efficiency of cell killing of ALSPC photosensitization was estimated by counting surviving cells with the method of trypan blue staining and by the method of radioisotope labelling. Experiments using the latter method also showed DNA damage caused by ALSPC photosensitization.

Cell Death↗
PubMed1990

Thymic-renal-anal-lung dysplasia in sibs: a new autosomal recessive error of early morphogenesis.

We report on 3 sisters with a syndrome of unilobed or absent thymus, renal and ureter agenesis/dysgenesis, and intrauterine growth retardation (IUGR). Two of the 3 infants had a unilobed lung and imperforate anus. Recurrence was detected prenatally by the presence of progressive oligohydramnios and IUGR, a unilateral echogenic cystic mass in the renal fossa, and low amniotic fluid disaccharidases in association with an imperforate anus. Several genetic mechanisms can be invoked to explain this occurrence including autosomal recessive inheritance and an unrecognized chromosome imbalance.

Abnormalities, Multiple↗
PubMed1990

Psammoma bodies in fine-needle aspiration cytology of papillary adenocarcinoma of the lung.

The fine-needle aspiration (FNA) cytology of two cases of papillary adenocarcinoma of the lung is reported. Both cases showed psammoma bodies and papillary clusters of tumor cells in FNA specimens. Both tumors were resected and confirmed as primary papillary carcinoma of the lung by histologic examination and by clinicopathologic exclusion of the possibility of metastasis from other organs.

Adenocarcinoma, Papillary↗
PubMed1990

Urachal signet-ring cell carcinoma.

A case of urachal signet-ring cell carcinoma is reported and compared with the 18 previously reported cases. This tumor appears aggressive, with a five-year survival rate of 27 percent. Only 1 patient achieved a five-year disease-free survival.

Adenocarcinoma, Mucinous↗
PubMed1990

Appendiceal adenocarcinoid with ovarian metastasis.

The clinicopathologic features of an appendiceal adenocarcinoid that metastasized to the ovary and peritoneum after a 5-year disease-free interval are presented. A review of the literature reveals that appendiceal adenocarcinoid in women has a high frequency (32%) of ovarian metastasis. Among 18 cases with ovarian metastasis, the ovarian metastasis was diagnosed at initial presentation in 13 cases. In the remaining 5 cases the ovarian metastasis developed after disease-free intervals ranging from 6 months to 8 years. In most cases, the ovarian metastasis was the main clinical presentation of the patients. In 5 cases the ovary was the only site of metastasis clinically when metastasis was first diagnosed. There is no known effective treatment for disseminated adenocarcinoid. It is advisable that oophorectomy be included routinely in the initial surgical treatment of appendiceal adenocarcinoid, with the possible exception of the rare pure tubular variant.

Adenocarcinoma↗
PubMed1990

Angiomyolipoma of the vagina.

An angiomyolipoma arising in the vaginal apex and presenting as a pelvic mass is reported and compared with other reported cases of extrarenal angiomyolipoma. This case appears to be the second case of angiomyolipoma arising in the vaginal wall.

Female↗
PubMed1990

Pleomorphic adenoma of the breast.

The clinicopathologic features of 2 new and 24 previously reported cases of pleomorphic adenoma of the breast are reviewed. This benign breast tumor resembles its salivary gland counterpart histologically. The circumscription and preferential juxta-areolar location suggest large breast duct origin of the tumors. Inappropriate surgery, i.e., mastectomy, was performed in 42% of the cases. Misdiagnosis and the resulting inappropriate treatment can easily be avoided if the pathologist includes this entity in the differential diagnosis when confronted with unusual differentiated epithelial breast lesions.

Adenoma↗
PubMed1990

Cartilage cells in cerebrospinal fluid.

A rare case in which cartilage cells were observed in cerebrospinal fluid is reported and the literature reviewed. This phenomenon, occurring in 0.2% of the cerebrospinal fluid specimens, is thought to be caused by accidental puncture of the intervertebral disk. It has the potential of being mistaken for a malignant process.

Cartilage↗
PubMed1989

Retroperitoneal seminoma and intratubular germ cell neoplasia.

A 30-year-old man with a 6-month history of flank pain was found to have a large retroperitoneal seminoma. A subsequent ultrasound examination revealed an inhomogeneous echo pattern in the normal-sized right testicle, which on orchiectomy showed extensive intratubular germ cell neoplasia. Level sectioning of the entire testicle revealed no extratubular extension of the tumor cells. The retroperitoneal and testicular lesions could represent double primaries. However, the possibility exists that an apparently intratubular germ cell neoplasm may not actually be an in situ lesion and that the retroperitoneal tumor in our case represents a metastasis from the intratubular germ cell neoplasia of the testicle.

Adult↗