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K T Chan

Publications and source records attributed to K T Chan.

21 records · Page 2Linked to original sources
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[Effect of strophanthin and celanide on the autoregulation of the cerebral blood flow].

It has been demonstrated in acute experiments on anesthetized cats that the control group animals manifested (before glycoside administration) a comparatively steady brain circulation accompanied by changes in the arterial pressure (AP) within 60-150 mm Hg. Intravenous injection of strophanthine (0.05 mg/kg) and celanide (0.1 mg/kg) improved autoregulatory reaction of the brain vessels during AP falling to lower levels as compared to control.

Animals↗
PubMedDate not supplied

[Effect of strophanthin and celanide on the tonus of the cerebral and peripheral vessels].

Resistography was used in acute experiments on anesthetized cats to demonstrate that cardiac glycosides, particularly celanide, often cause phasic (constrictive-dilative) responses of the perfused vessels and general arterial pressure. The constrictive response of the perfused vessels did not depend on the concentration of calcium ions in the blood and was not prevented by preliminary administration of dihydroergotoxin. However, glycosides prolonged the vasoconstrictive effect of noradrenaline. The vasodilative response to glycosides was reversed by atropine. It is assumed that the constrictive response is myotropic, whereas the dilative one is cholinergic in nature.

Animals↗