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Biomedical subjects

K Sueyoshi

Publications and source records attributed to K Sueyoshi.

At least 91 records · Page 5Linked to original sources
PubMed1989

Blockade by diazepam of conditioned fear-induced activation of rat mesoprefrontal dopamine neurons.

The effect of diazepam on activation of the mesoprefrontal dopamine (DA) system by an emotional stress model without direct physical stimuli was examined. Environmental stimuli previously paired with inescapable footshock (conditioned fear) elicited increases in levels of the DA metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), in the medial prefrontal cortex and of plasma corticosterone in rats. The increases in both levels were blocked by pretreatment with diazepam (5 mg/kg, IP); such blocking effects were reversed by Ro 15-1788 (15 mg/kg, IP), the benzodiazepine (BZD) receptor antagonist. These data suggest that diazepam can block activation of mesoprefrontal DA neurons as well as hypothalamo-pituitary-adrenocortical system elicited by the conditioned fear paradigm. This action appears to be a specific action of BZDs mediated through BZD receptors. We suggest that blocking effects of BZDs on the hyperactivity of the mesoprefrontal DA neurons may be one neural mechanism of their anxiolytic actions.

3,4-Dihydroxyphenylacetic Acid↗
PubMed1989

[Cerebral cysticercosis presenting as a solitary cyst. Diagnosis and treatment with CT-guided stereotactic biopsy--case report].

The patient, a 52-year-old male, experienced a generalized convulsive seizure. Computed tomography (CT) revealed a solitary, noncalcified cyst, 1 x 2 cm in diameter, in the left occipital lobe, without contrast enhancement. No other lesions were found in systemic soft tissues, skeletal muscles, or the eyes. A CT-guided stereotactic biopsy was performed through an occipital burr hole, and the diagnosis was cerebral cysticercosis. Although cysticercosis is still common in Mexico, Chile, and India, its occurrence has rarely been reported in Japan, especially since World War II. Intraparenchymal calcification and cystic lesions are common CT findings. However, in this case, a non-enhancing solitary cyst was the only CT finding. The authors review the literature and discuss the CT features and the usefulness of CT-guided stereotactic biopsy in the diagnosis and treatment of cysticercosis.

Biopsy↗
PubMed1985

Elastofibromatous lesion of the stomach in a patient with elastofibroma dorsi.

A 69-year-old woman underwent partial gastrectomy because of peptic ulcer which resisted medical treatment. The resected stomach exhibited a wide thickening of the antral wall around a 1.2 X 0.8 cm ulcer. The cut surface showed a gray-white thickened submucosal layer and had a rubbery elastic consistency. Microscopically, the thickened areas consisted of abundant acellular collagen fibers containing numerous elastinophilic, thick, serrated fibers and globules, identical with the elastofibroma fibers seen in elastofibroma dorsi. Reexamination of the patient revealed bilateral subscapular masses; one of these was biopsied and proved to be an elastofibroma dorsi.

Aged↗
PubMed1983

[Cerebrospinal fluid distributions of systemically administered fluorinated pyrimidines].

Transfer of systemically administered fluorinated pyrimidines (Tegafur, TAC-278, HCFU and FD-1) to cerebrospinal fluid was studied in 7 patients primary brain tumors. Seven patients had had irradiation and also had V-P shunt operation for hydrocephalus 5-FU concentration in CSF was extremely high in FD-1 and TAC-278 administration, but not in Tegafur and HCFU administration. In addition, Tegafur and HCFU did not reveal any cumulative effects of 5-FU in CSF by continuous prolonged systemic administration. The facts suggest strongly the usefullness of the agents in the treatment of intracranial neoplasms, which have high CSF concentrations. However, intermediate metabolites of 5-FU in CSF are different from those in systemic pathway, and FD-1 and TAC-278 produce CNS toxicities. Therefore, further extensive studies are necessary to utilize these agents for the treatment of intracranial neoplasms.

Adult↗
PubMed1983

[Esophageal cancer in chronic lymphocytic leukemia--a case report].

A 58-year-old male was admitted because of severe dysphagia. Radiographic and endoscopic examination revealed squamous cell carcinoma of the esophagus. Physical examination revealed severe splenomegaly and swelling of the cervical and axillary lymph nodes. Laboratory data showed lymphocytosis (more than 90%), severe anemia and monoclonal hyperglobulinemia (IgA type). The patient received irradiation (60 Gy) to the esophageal lesion using Linac X-ray and 40 Gy to the left cervical and axillary region with a tele Co60. Radiotherapy showed a remarkable effect not only on the esophageal cancer but also the chronic lymphocytic leukemia.

Carcinoma, Squamous Cell↗
PubMedDate not supplied

Three-dimensional CT angiography of the splenic-portal venous system by using multiple threshold display.

We assessed the three-dimensional (3D) CT angiographic reconstruction of the splenic-portal venous system obtained by using multiple threshold display (MTD) in 40 patients with liver disease. In each patient, both shaded surface display(SSD) and MTD images were generated by using an Xtension with a Sun SPARCstation 20, and they were compared by two radiologists. MTD image quality was superior to that of SSD images, because MTD diminished longitudinal direction artifacts and the image depicted the small vessels clearly. Based on the above results, we consider MTD to be a useful method for 3D-CT angiography of the splenic-portal venous system.

Angiography↗
PubMedDate not supplied

Optimal scan delay of arterial phase scanning of hepatic CT using a real-time image reconstruction system.

To optimize scan delay of arterial phase scanning of hepatic CT, 30 patients suspected of having HCC were examined using real-time image reconstruction technology (SureStart). In all cases, SureStart was successful. Despite the low dose, these images allowed adequate visualization of the abdominal aorta. The mean delay from the initiation of contrast administration to the beginning of arterial phase scanning was 29.6 +/- 5.2 sec (mean +/- SD; range, 22-51 sec).

Adult↗
PubMedDate not supplied

MR findings in isolated oculomotor nerve palsy associated with infectious mononucleosis caused by Epstein-Barr virus infection.

A 20-year-old man presented with fever, bilateral swelling of the cervical and inguinal lymph nodes, and splenomegaly. Later he noted diplopia. CSF was unremarkable. High serum antibodies to Epstein-Barr virus (EBV) were discovered. MRI revealed an abnormal lesion in the right third cranial nerve, which was considered to be the pathological lesion associated with his clinically apparent oculomotor nerve dysfunction.

Adult↗
PubMedDate not supplied

Helical CT of the liver with computer-assisted bolus-tracking technology: scan delay of arterial phase scanning and effect of flow rates.

PURPOSE: The purpose of this work was to assess the scan delay and the effect of flow rates on arterial phase scanning of hepatic CT. METHOD: One hundred twenty patients suspected of having hepatocellular carcinoma were examined by three-phase helical CT using computer-assisted bolus-tracking technology. We set the region of interest (ROI) in the abdominal aorta at the level of the celiac artery as a baseline. The triggering threshold was set at 100 HU. A volume of 100 ml of iomeprol (350 mg of I/ml) was administered at 2, 2.5, or 3 ml/s i.v. RESULTS: In all cases, helical CT scanning began after reaching the ROI threshold. Then, portal venous phase scanning was initiated 50 s after arterial phase initiation. The mean delay time from the initiation of contrast agent administration to the beginning of arterial phase scanning was 29.2 +/- 3.8 s (mean +/- SD, range 22-39 s). A faster injection rate significantly shortened the scan delay (p < 0.01). In portal venous phase scanning, calculated areas under the hepatic enhancement curves were almost equal among different injection rates. CONCLUSION: The computer-assisted bolus-tracking technology is a useful method for determining an individual scan delay of arterial phase CT.

Aged↗
PubMedDate not supplied

Fetal glioblastoma: rapid growth during the third trimester.

We present a case of fetal glioblastoma which appeared after 28 weeks' gestation. The first ultrasonographic finding was an enlarged fetal head with right shifted falx cerebri at 31 weeks' gestation. At 33 weeks, a large and high echogenic mass in the left hemisphere and right enlarged ventricle was identified. Magnetic resonance imaging showed that the tumor was localized in the left hemisphere and a margin of the tumor was defined. Because fetal well-being judging from biophysical parameters was good and we considered that the tumor was resectable, a male fetus weighing 2,670 g was delivered at 34 weeks' gestation by cesarean section. However, he was inoperable due to consumptive coagulopathy and rapid growth of the tumor, and died on the 41st day of life.

Adult↗
PubMedDate not supplied

Hemangioma of the umbilical cord: stenotic change of the umbilical vessels.

We report a rare case of an umbilical cord hemangioma diagnosed by ultrasound at 16 weeks of gestation. The umbilical cord consisted of a hemangioma nodule and pseudocysts near the placental insertion, a large gelatin-like swelling adjacent to the nodule on its fetal side, and a short normal part extending to the navel. At 17 weeks of gestation, this condition resulted in the intrauterine death of the fetus. Microscopically, there were communications between the capillary of the hemangioma and the umbilical vessels, verifying the origin of the tumor. Moreover, the umbilical vein and one of the arteries changed stenotically due to the intravascular proliferation of the hemangioma. These findings indicate the possibility of a pathological association between the umbilical cord hemangioma and fetal demise due to impaired umbilical circulation.

Adult↗