Biomedical subjects

K Sudo

Publications and source records attributed to K Sudo.

380 records · Page 22Linked to original sources

PubMedDate not supplied

Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM-1470).

Growth inhibition of tumor cells and vascular endothelial cells in M5076 tumors was examined following treatment with TNP-470 to elucidate its antitumor action. The bromodeoxyuridine-labeling index (LI) of tumor and endothelial cells was significantly decreased by TNP-470 treatment to 47 and 9% of the controls, respectively. The LI of endothelial cells was decreased earlier and more extensively than that of tumor cells. In contrast, the LI of endothelial cells was not decreased by treatment with chemotherapeutic agents, adriamycin and cisplatin, at the dose giving a similar growth inhibition on tumor cells. These results suggest that the antitumor action of TNP-470 is exerted by its angiogenesis inhibition.

Animals↗

PubMedDate not supplied

Inhibitory effect of TNP-470, a new anti-angiogenic agent, on the estrogen induced rat pituitary tumors.

An angiogenic inhibitor, TNP-470, is an analogue of fumagillin. This study reports the effects of TNP-470 and bromocriptine on the normal pituitary glands and estrogen-induced rat pituitary tumors. TNP-470 inhibited the increase of normal pituitary weight and the tumorigenesis induced by estrogen. The decreased labelling index in the pituitary cells, showed that TNP-470 may suppress the activity of cell proliferation as the result of anti-angiogenesis. Combination treatment with TNP-470 and bromocriptine was much more effective than TNP alone. These results suggest that TNP-470 is a potentially beneficial drug for pituitary tumors.

Animals↗