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Biomedical subjects

K Sterling

Publications and source records attributed to K Sterling.

64 records · Page 4Linked to original sources
PubMed1967

Thyroxine Turnover and Transport in Laennec's Cirrhosis of the Liver.

Studies of the metabolism of thyroxine in 14 cases of cirrhosis revealed a variety of deviations from normal. In addition to radiothyroxine turnover studies, determinations were made of the free thyroxine fractions and free thyroxine iodine concentrations in serum (magnesium precipitation method) as well as the maximal binding capacities of thyroxine-binding alpha globulin (TBG) and thyroxine-binding prealbumin (TBPA) by reverse flow paper electrophoresis in a glycine acetate system at pH 8.6.All cases of cirrhosis exhibited diminutions in TBPA capacities but their TBG capacities showed a wide scatter (13.4 to 41.6 mug/100 ml). The free thyroxine fraction was quite variable, with distinct elevations in nine of the 17 sera.The binding proteins appeared to be determinants of the free thyroxine fraction, which in turn, appeared to be a direct determinant of the half-time of turnover. These inferences did not exclude other possible factors including diminished hepatic uptake and metabolism of the hormone in liver disease.Despite considerable alterations in biological half-times, free thyroxine values, and binding proteins, it was remarkable that the absolute hormone disposal was normal in all 14 patients with cirrhosis.

Journal Article↗
PubMed1967

Thyroxine transport in thyrotoxicosis and hypothyroidism.

(a) The thyroxine-binding proteins were investigated in 23 cases of untreated thyrotoxicosis and 16 cases of untreated hypothyroidism, employing reverse flow paper electrophoresis with the glycine acetate system at pH 8.6 in the Durrum type cell.(b) In active thyrotoxicosis, all sera exhibited diminished thyroxine-binding prealbumin (TBPA) capacities. however, 17 of the 23 sera also had diminished thryroxine-binding alpha globulin (TBG) capacities, as well as markedly elevated free thyroxine fractions. In contrast, six thyrotoxic sera had normal TBG capacities and normal or slightly elevated free thyroxine fractions.(c) In hypothyroidism, the TBPA capacities showed no consistent deviation from the normal range. 11 of the 16 sera had elevated TBG capacities as well as markedly diminished free thyroxine fractions. In contrast, five hypothyroid sera had normal TBG capacities and normal or nearly normal free thyroxine fractions.(d) In thyrotoxicosis and hypothyroidism, the inverse correlation between free thyroxine fraction and TBG was much closer than that with TBPA. When diagnostic categories were considered separately, only TBG bore a significant inverse relation to the free thyroxine fraction. It is therefore suggested that in thyroid diseases TBG may sometimes play a more important role than TBPA in determining the free thyroxine fraction.(e) The demonstrated variations in the binding proteins were considered sufficient to explain the abnormalities of the free thyroxine fractions in thyroid disease.

Biological Transport↗
PubMedDate not supplied

A 24 year follow up of an isolated lymphangioma of the kidney.

Renal lymphangioma is a rare benign tumor of the kidney. An example is presented which was initially identified by excretory urography, angiography and biopsy. A 24 year follow up included computed tomography. The radiographic findings, pathogenesis and natural history of this unusual tumor are discussed.

Aged↗