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Biomedical subjects

K Stehr

Publications and source records attributed to K Stehr.

At least 73 records · Page 4Linked to original sources

Deficiencies of essential fatty acids and vitamin E in cystic fibrosis.

In 25 children (13 male; 12 female) with cystic fibrosis aged 6 months to 16 years and 24 matched controls total serum vitamin E levels and fatty acid patterns of serum cholesterol esters, phospholipids and triglycerides are demonstrated. Compared to controls (1.02 +/- 0.24 mg/dl) the total serum vitamin E levels are significantly decreased in patients with cystic fibrosis (0.30 +/- 0.26 mg/dl) (p less than 0.01). There is no significant difference comparing the fatty acid patterns of the serum ester fractions of both groups. Differences can be seen best in the cholesterol ester fraction. In this fraction linoleic acid shows a trend to be decreased in the cystic fibrosis patients compared to the control group. A possible influence of height velocity on the levels of essential fatty acids is discussed.

Adolescent↗

[Hearing loss due to mumps (author's transl)].

Several years post epidemic parotitis 765 children were examined to check possible hearing impairment. High peak was the year 1970 with predominant cases of parotitis with meningo-encephalitis in November/December. Boys (70.98%) were preferable attacked by the disease (age 5--7 years). Audiometric investigations were carried out in 359 cases (epidemic 1970) and 101 children (during 1975-1977), who had continuous control of hearing ability during hospital stay. 23 (4.9%) of the children showed impaired hearing (full deafness or high-tone hearing loss). No definite correlation to severity of parotitis, signs of meningo-encephalitis, location of infected glandula or length of sickness could be detected.

Age Factors↗

[The frequency of chronic and terminal renal insufficiency in childhood. Results of an inquiry in Bavaria (author's transl)].

The frequency of chronic renal insufficiency in children and adolescents up to the age of 17 was found by an inquiry addressed to 6625 doctors practising in Bavaria. The survey extended over an observation period of 5 years (1969-1974). According to the results, the frequency of chronic renal insufficiency in the age groups stated was calculated to be 8.7 per million inhabitants. An incidence of 0.83 per million inhabitants per year is to be expected for terminal renal insufficiency. From these figures the annual admissions for dialysis of patients aged between 0 and 17 years in Bavaria can be calculated at 9-13. To cater for these children with terminal renal insufficiency, the capacity must be increased from the present 10 to about 30 dialysis places in the next 5 years.

Adolescent↗

[Pathogenesis and therapy of shock in children (author's transl)].

The severely disturbed microcirculation characteristic of any type of shock leads to typical functional impairments in vital organs such as heart, brain, lungs, liver, kidneys and gut which, in turn, exert an adverse influence upon the process of shock. The insufficient circulation primarily of the gut and the liver causes even those forms of shock which are not initially triggered by endotoxin to develop into the ominous endotoxin shock unless rapid and effective therapy interrupts this vitious circle. The prognosis of shock depends on early diagnosis nad treatment. Therapy should be initiated even before diagnosis of the underlying disease has been completed. The following therapeutic factors require special consideration: Volume substitution, prevention of cardial decompensation and of impending uremia, prevention and treatment of respiratory failure, direct treatment of the disturbed microcirculation by means of peripherally vasodilating drugs and if necessary, suppression of the intravascular coagulation by means of plateled aggregation inhibiting, anticoagulant and fibrinolytic drugs.

Cerebrovascular Circulation↗

[Measles vaccination with split vaccines and living vaccines (author's transl)].

Two vaccination groups were observed over four years. One group received multiple preliminary vaccinations with measles split vaccine and were subsequently immunised with measles live vaccine. The second group received live vaccine only. The protection from the live vaccine, with and without the preliminary vaccination, must be considered very good, while the protection of a preliminary vaccination with split vaccine is only sufficiently effective for 1 1/2 to 2 years. All children-whether pre-vaccinated with split vaccine or not-should be protected against measles with live vaccine from the second year of life.

Age Factors↗