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Biomedical subjects

K Steele

Publications and source records attributed to K Steele.

At least 73 records · Page 4Linked to original sources
PubMed1988

Liquid nitrogen and salicylic/lactic acid paint in the treatment of cutaneous warts in general practice.

Patients with common hand warts and simple plantar warts attending a general practice wart clinic in Northern Ireland were assigned to one of three treatment groups - liquid nitrogen applied weekly, daily application of wart paint (lactic acid one part, salicylic acid one part, collodion four parts), or a combination of the two. Combination therapy cured 87% of common hand warts over a six week period, and was significantly more effective than either agent used separately (P<0.05). The results for simple plantar warts were disappointing and no treatment regimen proved to be significantly better than any other. These treatments were cheap, compliance and tolerance were good, and the six month recurrence rate was minimal. Given the likelihood that warts will multiply if left untreated we would recommend early active treatment for this condition.

Adolescent↗
PubMed1987

Repeat prescribing of non-steroidal anti-inflammatory drugs excluding aspirin: how careful are we?

About 5% of all National Health Service prescriptions in Britain and a quarter of reports of suspected adverse reactions are accounted for by non-steroidal anti-inflammatory drugs. Their prescription was investigated in two computerised group practices serving 11850 patients. Altogether 198 patients receiving repeat prescriptions of non-steroidal anti-inflammatory drugs were identified and relevant clinical details extracted from their notes. Of these patients, 119 were over 65 years old; 172 were receiving one of six different non-steroidal anti-inflammatory drugs; and 76 were taking drugs that can interact with non-steroidal anti-inflammatory drugs. Ninety one patients had one or more medical conditions that may be aggravated by non-steroidal anti-inflammatory drugs, and 36 had experienced side effects important enough for their treatment to be changed. A questionnaire to assess opinions and knowledge of non-steroidal anti-inflammatory drugs was given to 42 general practitioners and 26 rheumatologists. Although the two groups showed a comparable knowledge of the properties and costs of non-steroidal anti-inflammatory drugs, they differed significantly in their views on the circumstances under which these drugs should be used. Clear guidelines on the prescription of these drugs would indicate when careful monitoring is essential for patients to benefit from them safely.

Aged↗
PubMed1987

The impact of nursing diagnoses in a long-term care setting.

Nursing diagnosis as a critical component of the nursing process provides a common taxonomy to describe problems that nurses can treat and is a convenient, logical way to reference nursing standards. Theory is translated into practice with the use of population-specific prototype care guides and a written orders system. Nurses in leadership are responsible for providing the necessary resources to promote professional growth and facilitate desired change. Recommendations to assist with the implementation of nursing diagnosis are identified in Table 1. The system is dependent on staff nurses' professional commitment to learning and willingness to actively participate in change. Involvement of staff nurses continues to be a critical factor in the improvement of nursing practice.

Hospital Bed Capacity, 500 and over↗
PubMed1987

Students' awareness of and attitudes to AIDS.

Students' attitudes to and knowledge and awareness of the acquired immune deficiency syndrome (AIDS) was assessed by questionnaire. The recent information campaign reached a high proportion of the sample of 1063 students and television was the most memorable medium. Students were generally aware that AIDS was not associated with social contact but there was confusion about the risk of infection from donating or receiving blood, with 17.9% of blood donors now less willing to donate blood. Most of the students were aware that the condom reduces the risk of spread of AIDS sexually but there was no indication of widespread condom usage among the 399 students who admitted they were sexually active; 39.1% of this group used condoms alone or with other protection. Almost half the sample (47.6%) would like to have the opportunity to have their blood tested for the AIDS virus; 96 students would prefer this to be at a clinic and 59 of them would not wish their family doctor to know the result. A high proportion of the sample considered that AIDS victims should be cared for at home or in a special hospice.

Acquired Immunodeficiency Syndrome↗
PubMed1986

Effect on prescribing of the limited list in a computerised group practice.

The prescribing of drugs in the therapeutic classes that are affected by the government's limited list was investigated in a computerised group practice of just over 3,000 patients. Prescribable drugs in categories that are affected by the list were identified for two consecutive six month periods before and one six month period after the introduction of the list. A significant decrease in the prescribing of cough and cold remedies, vitamins, and antacids occurred after the list was introduced, whereas no change occurred in the prescribing of laxatives, benzodiazepines, or analgesics. The prescribing of iron and penicillin increased significantly after the list was introduced, whereas the use of H2 antagonists and non-steroidal anti-inflammatory drugs showed no significant change.

Drug Prescriptions↗
PubMed1986

Psychological and physiological reactions to visual representations of war.

This paper explores the immediate psychological and physiological effects of aversive visual stimuli, represented as pictures of war, in a balanced mixed design (n = 24). The moderating effects of individual differences in locus of control and sex were examined, along with those of a requirement to report on the stimuli presented. The results indicated a fractionation of the autonomic response with electrodermal measures (EDA) and salivary function showing a sympathetic type response to war slides whilst measures of cardiac activity (heart rate and heart rate variability) tended to show increased parasympathetic activity over the response to neutral slides. Psychological measures showed an increase in self-reported stress, higher disturbance ratings and unprompted reports of various coping strategies (postexperimental interviews) in response to war slides. Additionally, self reported arousal and EDA's proved sensitive to the report requirement and cardiac activity appeared to be tied to individual differences in terms of locus of control. Although the physiological results could be taken as congruent with Hare's (1972) suggestion that 'morbid curiosity' accompanies the viewing of aversive stimuli, psychological measures tended to disconfirm this interpretation. The situational determinants of the cardiac response are discussed as a solution to the paradoxical cardiac response elicited with aversive visual stimuli, along with individual styles of coping with aversive situations which may be reflected in individual's locus of control.

Adolescent↗
PubMed1985

Glycoprotein PAS-0 from the milk fat globule membrane carries antigenic determinants for epithelial membrane antigen.

Epithelial membrane antigen (EMA) can be found in human tissues using antisera raised against defatted human cream. PAS-0 is a glycoprotein which has been extracted from human milk fat globule membranes. Using a polyclonal antiserum and a series of monoclonal antibodies, we have shown that the major antigenic determinant for EMA is carried by PAS-0. A more detailed comparison of the two glycoproteins has been made by establishing a set of radioimmunoassays using the different antibodies.

Amino Acids↗
PubMed1985

Pinch grafting for chronic venous leg ulcers in general practice.

Twenty-five patients with chronic venous leg ulcers were treated in general practice by pinch grafting. Fifteen of the ulcers (60%) were completely healed one year after grafting. Prior to grafting 19 patients (76%) complained of daily pain in the ulcer. These patients experienced complete relief from pain after grafting. Pinch grafting is a simple, safe and effective therapy when applied in a domiciliary environment.

Aged↗
PubMed1984

Monoclonal antibodies that react with epithelial membrane antigen.

Previously reported immunohistochemical studies using three monoclonal antibodies reactive with the human milk fat globule membrane, LICR.LON.M8 and HMFG1 and 2 from the ICRF, have shown that their antigenic determinants have similar tissue distributions. These distributions are also similar to those shown by polyclonal sera against epithelial membrane antigen. Using a radioimmunoassay, we have shown that all three monoclonal antibodies react with epithelial membrane antigen. Immunofluorescent staining of cultures of human breast cells with these antibodies demonstrated that they are heterogeneous in their distribution. Although the results emphasized their similarities, differences between the antibodies suggested that they react with different epitopes on the same molecule. The use of these reagents in diagnostic tumor pathology is discussed.

Antibodies, Monoclonal↗
PubMed1984

Primary dermatological care in general practice.

Out of 2,409 clinical cases analysed over an eight-week period, 199 (8.2 per cent) were of a dermatological nature. Atopic eczema, warts, seborrhoeic eczema and acne vulgaris were encountered most frequently. The reaction to a skin clinic in the general practice, with access to liquid nitrogen, electrocautery and histopathology is described. Treatment of patients is summarized. It is suggested that having a practice skin clinic reduces the rate of hospital referrals by two thirds.

Adolescent↗
PubMed1983

Epithelial membrane antigen: partial purification, assay and properties.

The Epithelial Membrane Antigen (EMA) has until now only been described in immunological terms and has been shown immunohistochemically to be present on a variety of human non-squamous epithelial surfaces. It is a valuable marker in diagnostic tumour pathology and enables the detection of small deposits of malignant cells in organs such as liver and bone marrow. Its discovery in soluble form in human milk has enabled a purification of the antigen from this source. The antigenic activity in the milk is spread over a wide range of mol. wts and although purification causes a general reduction in size, the antigen remains heterogeneous. Carbohydrate forms the major component of the antigen with galactose and N-acetylglucosamine as the two major sugars. The protein content of EMA is low and shows considerable variation in amino acid composition from one sample to another. A high content of inorganic material has also been found in EMA but is not due to high sulphate or phosphate levels.

Carbohydrates↗
PubMed1982

Similarities of antisera to casein and epithelial membrane antigen.

Antisera raised against human milk fat globule membranes and against the casein fraction of human milk have been compared. Using an immunohistochemical stain of tissue sections it has been shown that many of the antigenic determinants detected by the different antisera are identical. A radioimmunoassay for epithelial membrane antigen (EMA) showed that casein preparations are associated with small quantities of EMA. Antisera to casein frequently contained appreciable concentrations of antibodies to EMA and this accounts for the immunohistochemical staining of non-mammary tissues.

Antigens, Surface↗