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Biomedical subjects

K Srinivas

Publications and source records attributed to K Srinivas.

At least 19 recordsLinked to original sources
PubMed1995

Representation of rotated objects in explicit and implicit memory.

The effects of rotating familiar and novel objects in depth between study and test were explored on short-term recognition, long-term recognition, and priming tasks. Short-term recognition memory was not affected by rotation in depth when the study and test views shared the same visible parts. However, long-term recognition was sensitive to rotation, even when all the parts were visible in both views. Priming was also affected by rotation, but only when study and test views did not share the same parts, or when test views were generated from rotations greater than 67 degrees. Together, the results suggest that long-term recognition memory is mediated by representations that specify viewpoint in depth precisely, whereas priming is mediated by representations that are more broadly tuned with respect to orientation. Furthermore, the insensitivity of the short-term recognition memory task to rotation suggests the possibility that viewpoint-invariant descriptions are generated from multiple successive views.

Humans↗
PubMed1993

ARTEMIS: a collaborative framework for health care.

Patient centered healthcare delivery is an inherently collaborative process. This involves a wide range of individuals and organizations with diverse perspectives: primary care physicians, hospital administrators, labs, clinics, and insurance. The key to cost reduction and quality improvement in health care is effective management of this collaborative process. The use of multi-media collaboration technology can facilitate timely delivery of patient care and reduce cost at the same time. During the last five years, the Concurrent Engineering Research Center (CERC), under the sponsorship of DARPA (Defense Advanced Research Projects Agency, recently renamed ARPA) developed a number of generic key subsystems of a comprehensive collaboration environment. These subsystems are intended to overcome the barriers that inhibit the collaborative process. Three subsystems developed under this program include: MONET (Meeting On the Net)--to provide consultation over a computer network, ISS (Information Sharing Server)--to provide access to multi-media information, and PCB (Project Coordination Board)--to better coordinate focussed activities. These systems have been integrated into an open environment to enable collaborative processes. This environment is being used to create a wide-area (geographically distributed) research testbed under DARPA sponsorship, ARTEMIS (Advance Research Testbed for Medical Informatics) to explore the collaborative health care processes. We believe this technology will play a key role in the current national thrust to reengineer the present health-care delivery system.

Computer Communication Networks↗
PubMed1992

The role of syllabic and orthographic properties of letter cues in solving word fragments.

The present research examined the role of phonological and orthographic properties of cues in mediating the retrieval of words from the mental lexicon. The task required subjects to resolve fragmented words when provided with semantically related cues (e.g., spiteful:---DIC----). Phonological properties of the letter cues were manipulated such that the letters either corresponded to the syllables (e.g., DIC in vindictive) or nonsyllables (NDI) in the word. Orthographic properties of the letter cues were manipulated by selecting letter groups that either co-occurred frequently in the language or did not. In two experiments, results revealed little or no effect of the phonological variable (syllables) but a reliable effect of the orthographic variable (letter-cue frequency). Letter cues with a low frequency of co-occurrence in the language led to better completion of the fragmented words. We interpret these findings as support for models of lexical representation that are based on orthographic properties (e.g., Seidenberg & McClelland, 1989) rather than those based on phonological constraints.

Adult↗
PubMed1991

Double-blind cross-over study of modified Anna Pavala Sindhooram in patients with hyperlipidemia or ischemic heart disease.

The plasma lipid lowering effect of modified Anna Pavala Sindhooram (APSm) was tested in 30 patients with plasma lipid abnormalities and with symptomatic ischemic heart disease (IHD) in a double-blind cross-over design. HDL2 cholesterol and total HDL cholesterol were increased during APSm therapy leading to a reduction in the coronary risk index. Plasma cholesterol, LDL and VLDL cholesterol, triglycerides, phospholipids and free fatty acids were significantly reduced during APSm therapy while withdrawal of the drug led to a slow increase in these lipids. No adverse side effects were noticed. Some patients were able to reduce their daily doses of antihypertensive and vasodilator drugs during APSm therapy.

Adult↗
PubMed1990

High incidence of subacute sclerosing panencephalitis in south India.

During 1983-7 a clinical diagnosis of subacute sclerosing panencephalitis (SSPE) was confirmed by the detection of measles virus haemagglutination inhibiting antibody in the cerebrospinal fluid (CSF) in 81 subjects resident in Tamilnadu. The antibody titre (reciprocol of the end-point dilution) in the CSF ranged from 2 to 32 and in the sera from 8 to 2048. The CSF:serum ratios of titres were 1:4-1:64 in 80 cases and 1:128 in one case. The median age at onset of SSPE was 10 years and 97% of cases were diagnosed at stage 2 and beyond. Based on the geographic distribution of 72 cases in an estimated population of 8.4 million, the annual incidence of SSPE was calculated to be 2.14 per million population, or 4.3 cases per million children below 20 years. Assuming that only 10% of all cases would have reached the level of laboratory diagnosis, the incidence may be as high as 21 cases per million population.

Adolescent↗
PubMed1990

Specifying criteria for postulating memory systems.

We have examined four criteria commonly used to distinguish separate memory systems: functional dissociation, independent neural systems, stochastic independence, and functional incompatibility. Current evidence fails to jointly satisfy these criteria in establishing independent systems, at least by our assessment. However, the proposed criteria are not all weighted equally in the literature. Certainly dissociation experiments, especially of neuropsychological patients, are weighted strongly in most formulations relative to the other three criteria. If all four criteria are considered equally important, as they should be in our opinion, evidence for the putative systems is much less clear-cut at this point, as indicated in our review.

Brain↗
PubMed1985

Sodium valproate in Sydenham's chorea.

Five patients with a moderate to severe degree of Sydenham's chorea were treated with sodium valproate for their involuntary movements. Within a week of commencement of treatment, the choreic movements disappeared completely. Sodium valproate appears to be a promising drug in the management of Sydenham's chorea.

Adolescent↗