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Biomedical subjects

K Sobue

Publications and source records attributed to K Sobue.

148 records · Page 9Linked to original sources
PubMed1977

Metabolism of putrescine in neuroblastoma and glioma cells during culture.

The metabolism of putrescine in neuroblastoma and glioma cells was analyzed during culture. In the former cells the formation of gamma-aminobutyric acid from putrescine was low and constant during the logarithmic phase and increased dramatically during the stationary phase or in cultures with low serum concentrations, while in the latter cells it was low and constant throughout culture. The formation of spermidine from putrescine in both cell lines was active at days 1-2 of culture and decreased gradually during culture. These findings indicate that spermidine formation is closely related to proliferation of the cells, and gamma-aminobutyric acid formation to differentiation or maturation of the neuroblastoma cells.

Cell Division↗
PubMed1976

The application of caerulein to cholangiography.

Caerulein was applied to oral cholecystography and the opacity of the common bile duct was evaluated at intervals. To 127 subjects whose gallbladder had been visualized by cholecystography was administered caerulein by intramuscular route in a dose of 0.2 mug per kg of body weight. As a result: 1. The visualization of the common bile duct reached its maximum 15 minutes after administration of caerulein (52% of the subjects); in total, 62.2% of the subjects responded to this cholecystography. 2. The visualization by caerulein was superior to that by the yolk both in its rate and intensity. 3. The cholangiogram taken after administration of caerulein was preferably available for diagnosis of bile duct lesions. Caerulein used for a pretreatment of drip infusion cholangiography (DIC) remarkably improved the picture in 3 of the 10 subjects in whom DIC alone had failed to show the bile duct. Thus, the application of caerulein to cholangiography facilitated diagnosis of bile duct lesions.

Bile Ducts↗
PubMed1976

Ocular sarcoidosis: evaluation of intraocular findings.

Intraocular lesions occurred in 55 of 70 sarcoidosis patients (78.6%) and their intraocular findings were biomicroscopically analyzed. Intraocular lesions were observed bilaterally in 54 of 55 patients (98.0%) and these various lesions occurred simultaneously or within a short period in almost all tissues of the eyeball. From these characteristics a new attempt was made to correlate the presence of sarcoidosis with intraocular findings. A gross positive correlation was revealed between the number of active intraocular lesions and the presence of sarcoidosis. Four to six active, bilateral intraocular lesions were found only in sarcoidosis. Although the correlation was not statistically tested, it should be clinically very useful in managing patients with suspicious intraocular lesions. Among the causes of visual disturbances secondary glaucoma was the most frequent. In 41 (37.2%) eyes various degrees of intraocular hypertension were observed. Impairment of aqueous outflow due to nodular infiltration of trabeculae was the fundamental mechanism in the rise of intraocular pressure. It should be emphasized that this peculiar trabecular finding can be identified only by a trained ophthalmologist and is very frequent in and characteristic of ocular sarcoidosis.

Eye Diseases↗