Search PubMed⌕ Search

Biomedical subjects

K Singh

Publications and source records attributed to K Singh.

At least 685 records · Page 38Linked to original sources

Large-scale transformation of steroids by fungal spores.

Spores of Aspergillus ochraceus and Septomyxa affinis were produced on a large scale by surface sporulation on moist wheat bran and barley. 11alpha-Hydroxylation of progesterone and Reichstein's compound S by spores of A. ochraceus and 1-dehydrogenation of compound S by spores of S. affinis were carried out in 5-liter fermentors. It was shown that, above a certain minimum, increase in aeration and agitation did not significantly affect steroid conversion. The industrial feasibility of the spore process was further demonstrated by 11alpha-hydroxylation of 6alpha-fluoro-16alpha,17alpha-dihydroxypregn-4-ene-3,20-dione in a modified 200-gal stainless-steel vessel with spores of A. ochraceus. Strict aseptic conditions are not necessary, either during harvesting of spores or during steroid transformation.

Adrenal Cortex Hormones↗

Proptosis migrans.

Explore the source record for details and available documents.

Exophthalmos↗