[Antiulcerogenic actions and other pharmacological properties of N-acetyl-L-glutamine aluminum complex (KW-110)].
Explore the source record for details and available documents.
Aluminum↗
Biomedical subjects
K Shuto
Publications and source records attributed to K Shuto.
Infrared spectra of a few transfer ribonucleic acids.
Explore the source record for details and available documents.
Amino Acids↗
Infrared spectrum of deoxyribonucleic acid. Effects of base composition and of N15-substitution.
Explore the source record for details and available documents.
Adenine↗
Infrared absorptions in the 1300 cm-1 region of deoxyribonucleic acid solutions with different base compositions.
Explore the source record for details and available documents.
DNA, Bacterial↗
A rapid analysis of inosinic acid and guanylic acid in their mixture by means of a bromination reaction.
Explore the source record for details and available documents.
Bromine↗
Effect of NG-nitro-L-arginine on age-related changes of glutamate receptor systems and immunophilin in rats.
We investigated the effects of age and NG-nitro-L-arginine methyl ester (L-NAME) on glutamate receptor systems and immunophilin in Fischer rat brain using receptor autoradiography. [3H]MK-801, [3H]glycine, sodium-dependent [3H]D-aspartate and [3H]FK-506 were used to label N-methyl-D-aspartate (NMDA) receptors, glycine receptors, excitatory amino acid transport sites and FK-506 binding proteins (FKBP), respectively. [3H]Glycine and sodium-dependent [3H]D-aspartate binding significantly reduced in the cerebral cortex, striatum, hippocampus, thalamus, substantia nigra and cerebellum of aged (24-month-old) rats in comparison with adult (6-month-old) animals. In contrast, [3H]MK-801 and [3H]FK-506 binding showed no significant changes in most brain regions of aged rats. Intraperitoneal chronic treatment with L-NAME (5 mg/kg, once a day for 4 weeks) showed no conspicuous changes in these binding sites in most brain areas of aged rats. In the cerebellum, however, this treatment showed a significant change in both [3H]MK-801 and sodium-dependent [3H]D-aspartate binding in aged rats. These results demonstrate that glycine receptors and excitatory amino acid transport sites are more susceptible to aging processes than NMDA receptors and FKBP. Furthermore, our findings may suggest a possible role of nitric oxide in the regulation of cerebellum during aging processes.
Aging↗