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Biomedical subjects

K Shida

Publications and source records attributed to K Shida.

At least 91 records · Page 5Linked to original sources
PubMed1977

Effect of estracyt on the rat prostate.

Two types of experiments were performed to elucidate the estrogenic effect of estracyt on the ventral and immature rats that had received injections of testosterone; then changes in weight of accessory rats and changes in weight of the total body, the ventral and the dorsolateral prostates, and adrenal gland, and changes in activities of testosterone 5alpha-reductase, alkaline phosphatase, and arginase of both lobes of the prostates were examined. In the second experiment, estracyt was injected into castrates rats and immature rats that had received injections of testosterone; then changes in weight of accessory sex organs were determined. Because similar changes were induced by treatment of animals with estradiol-17beta, it was concluded that the effect of estracyt on the prostates was most likely attributable to the estrogenic effect of the drug.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗
PubMed1976

Free amino acids in the caput and the cauda epididymis of adult rats.

To examine the content and the composition of free amino acids in the intraluminal fluid of rat epididymis, the fluids were obtained by light pressure on the dissected tissues. The amount of the total free amino acids in the pressed fluid from the caput epididymis was significantly higher than those of the cauda epididymis and the testis. Glu and Gln were predominant amino acids in the caput, and their amounts occupied more than half of the total ninhydrin reactive compounds. Such a high concentration of Glu and Gln was not observed either in the cauda or in the testis. Castration decreased Glu and increased Gln in amount. Testosterone treatment to castrated animals did not restore Glu and Gln contents in the pressed fluid from the caput epididymis to the level observed in intact rats completely. Therefore, it was assumed that a large amount of Glu in the caput was due to many factors; secretion and metabolism of epithelial cells of the gland which might be regulated by androgen, inflow of rete testis fluid, and sperm metabolism of amino acids in the epididymis. The results obtained from the caput epididymis to which the efferent duct of the testis was ligated also supported this interpretation.

Amino Acids↗
PubMed1975

Effect of estrogen administration on activities of testosterone 5alpha-reductase, alkaline phosphatase and arginase in the ventral and the dorsolateral prostates of rats.

Daily treatment with 5 or 500 mug of estradiol benzoate of male adult rats for 7 days did not change the activity of testosterone 5alpha-reductase in the ventral prostate, while the activity decreased slightly in the dorsolateral prostate. The activity of alkaline phosphatase was increased by 60% over the respective control in the ventral prostate from rats treated with the larger dose of estrogen, but the estrogen treatment did not affect the alkaline phosphatase activity in the dorsolateral prostate. On the contrary, the estrogen treatment evoked three-fold elevation in the arginase activity of the dorsolateral prostate in contrast to the decreased arginase activity in the ventral prostate following estrogen administration. From these results, it was concluded that the alterations in some enzyme activity of the ventral and the dorsolateral prostates evoked by estrogen treatment were different from those observed in the respective lobes from castrated animals, although both estrogen administration and castration induced atrophy of the tissue. Furthermore, it might be also worth-while to mention that the ventral and the dorsolateral prostates of rats responded in a different manner to estrogen administered.

3-Oxo-5-alpha-Steroid 4-Dehydrogenase↗