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Biomedical subjects

K Shichinohe

Publications and source records attributed to K Shichinohe.

6 recordsLinked to original sources
PubMed1990

Decrease in mitogen-induced lymphocyte proliferative responses in cats infected with feline immunodeficiency virus.

The blastformation tests using concanavalin A and pokeweed mitogen were carried out on peripheral blood lymphocytes obtained from cats infected with feline immunodeficiency virus (FIV). The infected cats included those showing multiple chronic disease, those with a single mild sign, and one with no clinical sign. The infected cats showed significantly lower mitogenic responses of peripheral lymphocytes to both mitogens and lower lymphocyte counts as compared to uninfected healthy cats. These immunologic alterations in the infected cats may be closely related to the development of immunodeficiency-like disorders associated with FIV.

Animals↗
PubMed1990

Kidney complications in EMC virus-induced diabetes in conventional DBA/2 male mice.

Conventional DBA/2 male mice of about 9 weeks of age were inoculated by intraperitoneally injecting EMC virus M variant (10(4) TCID50/0.1 ml/animal) which is passaged in mice. The mice which tested positive for glycosuria and hyperglycemia were examined histopathologically 2 or 5 months after inoculation. The kidneys were examined for thickening of Bowman's capsule and the mesangial matrix. These changes were more clearly observable 5 months after inoculation than they were 2 months after inoculation.

Animals↗
PubMed1990

Effect of rearing conditions on encephalomyocarditis (EMC) virus-induced diabetes in mice.

To compare the incidence in the diabetic syndrome in mice reared under sterile and non-sterile conditions, both conventional and SPF DBA/2 N male mice were inoculated intraperitoneally with two doses (10(4) TCID50/0.1 ml or 10(5) TCID50/0.1 ml) of encephalomyocarditis (EMC) virus M variant. The incidence of diabetic symptoms was higher in mice reared under sterile conditions than under non-sterile conditions. It appeared that a difference in animal rearing conditions would affect the sensitivity to EMC virus in mice.

Animal Husbandry↗