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Biomedical subjects

K Shanley

Publications and source records attributed to K Shanley.

5 recordsLinked to original sources
PubMed1997

Dominantly inherited epidermal acantholysis in dogs, simulating human benign familial chronic pemphigus (Hailey-Hailey disease).

We report on dominantly inherited epidermal acantholysis in three dogs, a sire and two female offspring. The skin lesions were characterized by hairless, hypertrophic plaques. Histopathologically, these lesions showed epidermal hyperplasia with individual enlargement of keratinocytes, extensive acantholysis and minimal dyskeratosis. Ultrastructural analysis revealed that attachment plaques of desmosomes were still intact while some tonofilaments were detached from them in early lesions; there were well-developed microvilli at dissociated cell surfaces. The data imply that these animals have undergone a process similar to human benign familial chronic pemphigus (BFCP). Immunohistochemical examination revealed that staining for E-cadherin and actin variably remained in dissociated keratinocytes. Focal intracellular staining for desmosomal glycoproteins and desmosomal proteins were observed within the dissociated keratinocytes. This dominantly inherited acantholytic disease in dogs could be a useful animal model for investigating the pathogenesis of BFCP in humans.

Acantholysis↗
PubMed1991

Dialyser reprocessing with Renalin.

We evaluated the dialyser reprocessing agent Renalin in a 6-month prospective study of 2,759 dialyses on 59 patients. Dialysers were withdrawn after a maximum of 6 uses, and the average number of uses achieved was 4.5 Dialyser survival varied with the type of dialyser but was unaffected by the dialysate base. In vivo clearances of urea, creatinine and phosphate were not altered by reuse, but there was a small decrease in ultrafiltration characteristics of used dialysers. No clinically significant adverse event was attributed to reuse. Blood pressure was better preserved with used dialysers, and patients experienced significantly fewer intradialytic symptoms. Savings of over +A 25,000 were achieved during the study.

Acetates↗
PubMed1984

High frequency of HLA-Bw16 in patients with anorexia nervosa.

Anorectic patients (N = 37) had a higher frequency of HLA-Bw16 than normal controls, due to the higher frequency of HLA-Bw38. They also had a higher rate of A26-Bw38. HLA typing may lead to hypotheses about the biology of anorexia nervosa.

Adolescent↗
PubMed1981

HLA antigens in mucocutaneous lymph node syndrome in New England.

HLA antigens were evaluated in 27 patients with mucocutaneous lymph node syndrome (Kawasaki disease) in the Boston area. In contrast to previous Japanese studies, no increase of HLA-Bw22 was found. A significant increase (P less than .002), however, in HLA-Bw51 was found in the patients with mucocutaneous lymph node syndrome as compared to an appropriate control population. To our knowledge, this is only the second disease associated with HLA-B5 specificity. The observations illustrate the lack of unified genetic predisposition for a such disease in two ethnic groups, white and Japanese. Such findings may have genetic implications regarding interhuman variation in immune responsiveness.

Boston↗