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Biomedical subjects

K Shanker

Publications and source records attributed to K Shanker.

At least 73 records · Page 4Linked to original sources
PubMed1984

Anti-inflammatory activity of amino acyl benzoates.

Nineteen new piperazino or morpholino amino acyl benzoates were synthesized and screened against carrageenin induced oedema in albino rats. Several compounds of the series showed potent anti-inflammatory activity. Compound 10 was found to be the most potent. This compound was further evaluated in detail and compared with phenylbutazone for its relative anti-inflammatory potency and ulcerogenic liability. The compound, in addition, was compared with acetyl salicylic acid for its analgesic activity. This compound showed potent ant-inflammatory activity with minimal ulcerogenic liability.

Aminobenzoates↗
PubMed1984

New guanine deaminase inhibitors.

2-Aryl/alkyl-3-(5'-carboxamido-imidazol-4'-yl)-quinazolin-4-(3H)-o nes have been reported as Guanine deaminase inhibitors. These compounds were prepared from 4-amino-5-imidazol-carboxamide and suitable 2-aryl/alkyl-benzoxazin-4-ones. Compounds were characterized by their m.ps., elemental analyses and I. R. spectra. These compounds have shown significant inhibition, aryl substituent was more effective than alkyl group. This is the first report when quinazolones have been reported as Guanine deaminase inhibitors. Inhibitors of this enzyme can enhance the bioavailability of purine antagonists and in turn are helpful for the chemotherapy of cancer.

Aminohydrolases↗
PubMed1983

Newer formazans and tetrazolium indoles as potential CNS-active agents.

Some new 2-aryl-5-(3'-indole)-3'-substituted phenyl tetrazolium bromide/iodide salts (IV) were synthesized by the oxidation of 1-aryl-3-(3'-indole)-5-substituted phenyl fromazans (III). These compounds III and IV were evaluated for their monoamine oxidase (MAO) inhibitory activity in vitro and various CNS activities in vivo. Several compounds exhibited promising CNS activities, III-b being the most active member of the present series showing marked antidepressant and MAO inhibitory activities and having low toxicity.

Animals↗
PubMed1982

Amoebicidal and fungicidal activities of new quinazolones.

Eleven quinazolones were synthesized by condensing 2-phenylanthranil with a suitable peptide in pyridine. The compounds synthesized were characterised by their sharp melting points, elemental analysis and IR spectra. The newly synthesized compounds were tested for their amoebicidal and fungicidal activities. Some of the compounds showed promising results.

Amebicides↗