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Biomedical subjects

K Seo

Publications and source records attributed to K Seo.

At least 127 records · Page 7Linked to original sources
PubMed1986

[Fundamental and clinical studies on ceftazidime in neonates and premature infants].

Ceftazidime (CAZ) was administered to 34 full-term and premature infants aged 0-27 days with various bacterial infections in a dose of 10 or 20 mg/kg by intravenous bolus injection, and plasma concentrations and urinary recovery rates in these subjects during recovery periods were studied. Because of the small number of the cases recruited, neonates were not divided into the full-term and the premature group, but into 3 groups based on day-age: 0-3 days, 4-7 days, and 8 days or older. Concentrations and rates of transfer of CAZ into cerebrospinal fluid (CSF) were determined in 2 cases, and biliary concentrations in another case. A clinical evaluation of CAZ was performed in 12 male and 6 female infants aged 1 day to 4 months and 19 days, including 2 each with purulent meningitis, pneumonia and pyelonephritis, 3 with septicemia, 1 each with septicemia suspected, cholangitis, osteomyelitis, bronchopneumonia, staphylococcal scaled skin syndrome, and acute enterocolitis and 3 for prophylactic use. Plasma concentrations and urinary recovery rates of CAZ The intravenous bolus injection at 10 mg/kg. Peak plasma concentrations of CAZ were obtained at the first collection (30 minutes) of blood samples or 1 hour in all 3 groups, ranging from 23.3 to 26.9 micrograms/ml with no significant variations, plasma concentrations then slowly decreased, and were still 6.04-9.88 micrograms/ml even at 6 hours after the administration. The half-lives of CAZ in plasma tended to be shorter in older day-age neonates, with mean half-lives being 3.59, 2.50 and 2.50 hours for the youngest. The intravenous bolus injection at 20 mg/kg. Peak concentrations were obtained at the first collection of blood samples in all 3 groups (0-3 days: 15 minutes, the others: 30 minutes), being 54.8, 39.9 and 43.8 micrograms/ml, respectively, then slowly decreased and were still 10.4-15.7 micrograms/ml even at 6 hours after the administration. Inter-age differences in half-lives were marked, i.e., 3.6 hours in 0-3-day group, 3.48 hours in 4-7-day group and 2.75 hours in 8-day or older group. Urinary recovery rates were about 40-60% without reference to day-age neonates. CSF concentrations About 50 mg/kg of CAZ was given to each of 2 cases.(ABSTRACT TRUNCATED AT 400 WORDS)

Bacterial Infections↗
PubMed1985

[Evaluation of neurogenic bladder in patients with spinal cord injury using a CMG.EMG study and CMG.UFM.EMG study].

Simultaneous recording of intravesical pressure, sphincter electromyography and uroflowmetry (CMG.UFM.EMG study) was performed following cystometry simultaneously with electromyography (CMG.EMG study) on 20 patients with spinal cord injuries. Differences in the influence to micturition between the CMG.EMG study and CMG.UFM.EMG study is thought to be due to whether the catheter is indwelling in the urethra or not. We examined those differences and patient's rehabilitation maneuver (Cred'e maneuver). Micturition pressure and opening pressure measured by the CMG.EMG study were larger than that measured by the CMG.UFM.EMG study (P less than 0.05, P less than 0.01 respectively). Incidence of detrusor-sphincter dyssynergia measured by the CMG.EMG study was greater than that measured by the CMG.UFM.EMG study in the detrusor hyperreflexic cases. The Cred'e maneuver caused increase in opening pressure, micturition pressure and peak flow rate, but the voiding volume and voiding time did not increase to any effective extent. The Cred'e maneuver exaggerated the detrusor sphincter dyssynergia.

Adult↗
PubMed1984

Synthesis of 1,2,3,4-tetra-O-acetyl-5-deoxy-5-C-[(R) and (S) -methoxyphosphinyl]-alpha- and -beta-D-ribopyranoses.

Treatment of methyl 5-deoxy-5-C-( diethoxyphosphinyl )-2,3-O-isopropylidene-beta-D- ri bofuranoside with sodium dihydrobis (2- methoxyethoxy ) aluminate , followed by hydrogen peroxide, mineral acid, and hydrogen peroxide, gave 5-deoxy-5-C-( hydroxyphosphinyl )-alpha,beta-D- ribopyranoses in 40-45% overall yield. The structures of these sugar analogs were effectively established on the basis of the mass and 400-MHz, 1H-n.m.r. spectra of the title compounds, derived by treatment with diazomethane and then acetic anhydride in pyridine.

Deoxyribose↗
PubMed1984

Cerebral energy state and glycolytic metabolism during enflurane anesthesia in the rat.

The effects of enflurane anesthesia on the cerebral cortical energy state and glycolytic metabolism were studied in rats. Twenty-four rats were divided into four groups with increasing concentrations of enflurane in the arterial blood, i.e. control (1.9 +/- 0.3 mg/dl, means +/- s.e.mean), level I (16.1 +/- 1.1 mg/dl), level II (26.0 +/- 1.6 mg/dl), and level III (32.9 +/- 0.9 mg/dl). At level I, high voltage 1-3 Hz slow waves superimposed on low voltage 10-12 Hz waves were predominant, and at levels II and III, spiking activity and burst suppression were recorded in the EEG. The duration of suppression at level III was significantly longer than that at level II. During enflurane anesthesia, there were no significant differences compared with the control group in the cerebral energy state or energy charge. Glycolytic metabolism remained unchanged except for an increase in glucose at levels II and III. Effects of hypocapnia and hypercapnia were examined in an additional 12 rats with an enflurane concentration in the blood similar to that at level II. Irrespective of PaCO2 levels, there were no significant changes in cerebral energy charge and glycolytic metabolites except for a decrease in glucose and an increase in lactate at hypocapnia. It was concluded that there was neither evidence of derangement of energy state nor increased anaerobic metabolism in the cerebral cortex during enflurane anesthesia.

Anesthesia↗
PubMed1984

[Fundamental and clinical evaluation on ceftriaxone in the pediatric field].

Fundamental and clinical evaluation on ceftriaxone (Ro 13-9904, CTRX) was performed. CTRX was compared with CEZ, CMZ, CTX and LMOX in the antibacterial activity against the clinical isolates such as S. aureus, E. coli, P. mirabilis, K. pneumoniae and S. marcescens. Against S. aureus, the MIC of CTRX ranged from 0.2 to greater than 100 micrograms/ml with a peak of 3.13 micrograms/ml, showing that CTRX was almost equal to CTX in activity, slightly superior to LMOX and much inferior to CMZ and CEZ, although some strains were not susceptible to CEZ. Against the intestinal strains of E. coli, K. pneumoniae and P. mirabilis, the MIC distribution of CTRX was similar to that of CTX and LMOX while CTRX showed the MIC as high as 3.13 micrograms/ml or above against 44% of all strains including the beta-lactamase producing strains of E. coli and K. pneumoniae, indicating a slight tendency of their becoming resistant. The MIC peaks against E. coli, K. pneumoniae and P. mirabilis were less than or equal to 0.1, 0.39 and less than or equal to 0.1 microgram/ml, respectively. As to S. marcescens which is drawing attention as a causative agent for infections inside of hospitals or those among young infants, CTRX inhibited 84% of the strains at 3.13 micrograms/ml, showing a definite superiority to CEZ and CMZ and a slight superiority to CTX and LMOX. The serum concentration after a single intravenous injection with 40 mg/kg reached a mean peak of 168.8 micrograms/ml at the first blood sampling (at 30 minutes) and gradually decreased to 137.5 micrograms/ml at 1 hour, 30.9 micrograms/ml at 6 hours, 12.6 micrograms/ml at 12 hours and 3.8 micrograms/ml at 24 hours, while the half-life time was 6.0 hours. The comparison of the serum level by 1 hour intravenous drip infusion between the dosage groups of 20 mg/kg and 40 mg/kg revealed that the former group reached a peak of 85.4 micrograms/ml at the termination of drip while the latter's peak was 176.6 micrograms/ml observed during the drip (30 minutes after the initiation of drip). The respective levels of the 2 groups were 15.4 and 32.1 micrograms/ml at 6 hours, 5.1 and 15.0 micrograms/ml at 12 hours, and 1.6 and 4.1 micrograms/ml at 24 hours, indicating a distinct dose-response 2 hours after the initiation of drip administration. The half-life times were 4.9 and 6.2 hours, respectively, which are the longest among the cephalosporins presently being developed.(ABSTRACT TRUNCATED AT 400 WORDS)

Bacteria↗
PubMed1984

[Retrovesical sarcoma (rhabdomyosarcoma): report of a case and a review of 46 cases in Japan].

The patient was a 2-year-old boy, who was brought to our clinic with the chief symptom of urinary retention. We suspected retrovesical tumor by digital examination, intravenous pyelography and retrograde cystography. Surgery was performed and the bladder and prostate including the tumor were removed. Ureterocutaneostomy was constructed on both sides. The pathohistological diagnosis was rhabdomyosarcoma (embryonal type). Thereafter, chemotherapy and irradiation were applied, but the patient died of cachexia which was clinically caused by a local recurrence, fourteen months after the operation. Forty-six cases of retrovesical sarcoma were collected from the recent Japanese literature, and reviewed.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1983

[Clinical study of male infertility].

A statistical analysis was performed on infertile male patients who visited our urological clinic between Jan. 1976 and Dec. 1981. The incidence of infertile male was 9.9% of the total male out-patients. Age distribution of most of the patients ranged from 25 to 34 years old. Infertile period was most commonly within 5 years after they had married. In semen analysis, the cases of azoospermia and oligozoospermia (less than 50 x 10(6)/ml) accounted for 80% of all the infertile males. Testicular histology showed hypospermatogenesis or "Sertoli cell only" in most patients (more than 84.2%) who received testicular biopsy. Decrease in testicular volume was accompanied by an increase in the serum levels of luteinizing hormone and follicle stimulating hormone, but there was no relationship between testicular volume and testosterone. Most of the patients with a testicular volume of less than 12 ml were azoospermic. This suggests that there may be a suppression of spermatogenesis in small testes.

Adult↗