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Biomedical subjects

K Sentinella

Publications and source records attributed to K Sentinella.

3 recordsLinked to original sources
PubMed1988

Apheresis techniques in lymphokine-activated killer cell production.

Adoptive transfer of autologous lymphokine-activated killer cells (LAK) in conjunction with recombinant interleukin-2 (rIL-2) has been reported to produce significant regression in metastatic disease in patients with advanced cancer. In an effort to confirm the results reported by the Surgery Branch of the National Cancer Institute, the same IL-2/LAK regimen was used in cancer patients at six extramural cancer centers. In this report we will review our experience with mononuclear cell removal from the blood of cancer patients using apheresis technology and extracorporeal handling of these cells to generate a selective, highly cytotoxic cell population.

Adult↗
PubMed1982

Erythrocytapheresis (red cell exchange).

Automated erythrocytapheresis (red cell exchange) was performed on two patients with sickle cell disease using the IBM 2997 Blood Cell Separator. Preoperative red cell exchange was performed on patient L.N. to prevent possible anterior ischemic syndrome during surgery. A red cell exchange procedure on patient A.Y. diminished her acute sickle crisis symptoms and resolved respiratory complications. For each patient, the instrument settings were varied in order to achieve the desired effect for the hematological needs of the individual patient.

Acute Disease↗