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Biomedical subjects

K Senior

Publications and source records attributed to K Senior.

124 records · Page 7Linked to original sources
PubMed1997

How can components of common foods affect cancer risk?

Strong epidemiological evidence implicates diet in a substantial proportion of cancer cases. Nutritionists largely agree on the attributes of a healthy diet for cancer prevention (and also for cardiovascular health). Researchers are now studying specific food components that can actively suppress the processes involved in carcinogenesis. The most potent of these could be used directly for chemoprevention in high-risk individuals and might even have potential in cancer therapy.

Animals↗
PubMed1997

Obesity: how can it be controlled?

Obesity is a complex condition. In humans, it depends on a variety of social, cultural and behavioural factors acting on the physiological mechanisms that dictate food intake and energy expenditure. In the past decade, details of these mechanisms and of the genes that control them have started to unfold. Are we, however, at risk of pursuing the more molecular aspects of this twentieth-century epidemic while allowing the stigma of obesity to prevent us from implementing radical treatment programmes that could prevent many premature deaths in the short term?

Adult↗
PubMed1997

Molecular medicine and population control.

As we uncover the physiological and molecular mechanisms behind human reproduction, we gain the potential to exert more control over our reproductive capabilities. In the past two decades, the prospects for 'infertile' women to bear children, or 'sterile' men to father them, have improved dramatically; recently, women have given birth in their sixties, well beyond their natural menopause. Thanks to developments in contraception, couples can now enjoy an active sex-life without a significant risk of pregnancy, and more accurately control the size and timing of their families. But these new freedoms have a price: they also have the potential to cause demographic distortions, medical harm to individuals and abuse of human rights.

Contraception↗
PubMed1996

Acupuncture: can it take the pain away?

Acupuncture is growing in popularity in most Western countries and continues to be a major form of medicine in China and Japan. In the USA, an estimated ten million consultations for acupuncture take place each year. Many scientists regard acupuncture, like many other 'alternative' therapies, as an over-dressed placebo that fulfils a need for mysticism and ancient ritual. But if we dismiss acupuncture in this way, are we rejecting an opportunity to learn more about the body's response to pain?

Acupuncture Analgesia↗
PubMed1988

Gonococcal variants selected by growth in vivo or in vitro have antigenically different LPS.

Lipopolysaccharide (LPS) was extracted from two variants of strain gc40 of Neisseria gonorrhoeae obtained by repeated subculture in vitro or by growth in vivo in a subcutaneous chamber. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis followed by silver stain analysis revealed that both variants had three main LPS components, but the large size components were predominant in gonococci selected in vivo and the smallest size in those selected in vitro. Western blotting, ELISA and ELISA inhibition using monoclonal and polyclonal antibodies showed that the two variants had antigenically different LPS and that serum sensitivity may be due to the antigenic specificity of the large components. These results indicate that during infection clones of gonococci are selected with LPS of antigenic and physicochemical composition different from those seen after repeated subcultures.

Animals↗
PubMed1985

The characterization of [3H]sulpiride binding sites in pig striatal membranes.

Pig striatal membranes have [3H]sulpiride-binding sites similar to those identified in rat striatal membranes. The pharmacological profile indicates that this binding is to dopamine receptors. Agonist displacement of [3H]sulpiride binding in pig striatal membranes is subject to guanine nucleotide regulation. This effect is mimicked by heat treatment. N-ethyl maleamide (20 microM) and dithioerythritol (3 mM) decrease agonist affinity for the [3H]sulpiride-binding site in pig striatal membranes without significantly affecting maximal displacement.

Animals↗
PubMed1984

Peer presence and the exploratory behavior of eighteen- and thirty-month-old children.

20 18- and 20 30-month-old children were observed in a situation requiring separation from the mother in order to play with attractive toys. An agemate was present for half the children but not the others. Peer presence facilitated leaving the mother and entering the playroom at both ages. Among 18-month-olds, the presence of the peer also shortened play bouts, increased unoccupied/self-solace behavior, and increased contact maintenance with the mother. Among 30-month-olds, however, the peer's presence did not have these effects. these children engaged in increased coordinate social interaction with the other child. Developmental changes occurring in the second and third year thus include the increased salience of agemates in supporting separation from the mother and exploration of the environment in the context of sustained social interaction.

Child Development↗