Biomedical subjects

K Seitz

Publications and source records attributed to K Seitz.

76 records · Page 5Linked to original sources

PubMed1982

[Ultrasound detection of free air in the abdominal cavity].

Diagnosis via x-ray film had so far been the only way to prove the existence of free air in the abdominal cavity and hence the presence of gastrointestinal perforation. However, it is possible to establish the existence of free air in the abdomen sonographically provided a suitable examination method is employed. A characteristic feature is represented by pronounced pre-hepatic echoes with multiple echoes or sound shadow phenomenon. Experimentally it was possible to identify 1 ml air in the abdomen of an ascites patient both by x-ray examination and by sonography with equal certainty. The clinical usefulness of the ultrasound method was scrutinized. Of 10 patients with gastrointestinal perforations, 9 were recognized by sonography, including roentgen-negative cases; in one case only, sonography yielded a false negative result. Sonographic differential diagnosis is more versatile and differentiation can be practised by the highly experienced investigator only. The proof of the existence of free air in the abdomen represents a considerable extension of the scope of sonographic emergency-case diagnosis.

Abdomen, Acute↗

PubMed1981

[ECG seminar IV].

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Echocardiography↗

PubMed1981

Policy choices available in genetic counseling for people at-risk for Huntington's disease.

Staff on 94 wards in 78 Veterans Administration Medical Centers caring for Huntington's disease patients were interviewed by telephone to determine their policy, practice, and attitude regarding counseling HD families. Considerable variability among wards within a given hospital and among different hospital was reported. Presentation of genetic information was found to be significantly associated by statistical tests with existence of some kind of ward counseling policy, treatment on a neurology ward, active seeking-out of relatives, construction of pedigree charts, and specific staff designated to provide such counseling. Genetic discussions with families of HD patients and at-risk kindreds raise some sensitive ethical questions, notably the vigorous denial of disease in these families, the high suicide rate of those at-risk, and consideration of patients' rights regarding privacy of medical data. A consistent genetic information-giving policy, at least among wards of each hospital and possibly among all hospitals within a large hospital system, is recommended as a logical and desirable goal.

Genetic Counseling↗

PubMed1968

Invertase activity and cell growth in lentil epicotyls.

The activity of invertase and its relation to growth were studied in the epicotyls of lentil seedlings incubated in the presence and absence of gibberellic acid (GA(3)).Invertase activity per epicotyl increases relatively more rapidly than does length, reaches a maximum during most active elongation, and declines upon cessation of growth.GA(3) enhances both growth and increase in invertase activity, without altering the kinetics of the 2 processes. If GA(3) is added during incubation invertase activity increases more rapidly than does elongation rate.Incubation of the seedlings in solutions of polyethyleneglycol inhibits the increase of both growth and invertase activity, the latter actually undergoing a decline, but causes no great change in the relative effect of GA(3). In presence of polyethyleneglycol GA(3) has however a relatively greater effect on invertase activity than on growth.Sugars in the incubation medium have no significant effect on growth and invertase activity in the epicotyl, except inhibition at relatively high concentrations.Cycloheximide, actinomycin D, and 5-fluorodeoxyuridine (FUDR) inhibit both growth and the increase in invertase activity. Added during incubation cycloheximide causes complete inhibition of growth and a decrease in invertase activity with no appreciable lag phase. With actinomycin D and FUDR the inhibition occurs after lag periods of 2 to 3 and of at least 10 hours, respectively. Thus the increase in enzyme activity is very probably based on de-novo synthesis, and the enzyme is in a state of turnover during growth.The enzyme is present in soluble form in the cytoplasm, not firmly bound to any cell structures.

Journal Article↗