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Biomedical subjects

K Schultz

Publications and source records attributed to K Schultz.

At least 109 records · Page 6Linked to original sources
PubMed1980

The metabolic consequences of human milk and formula feeding in premature infants.

Twenty premature low-birthweight infants were divided into two groups and assigned randomly to either a pooled human milk or to a cow's milk based infant formula feeding regimen. The protein intake was 2.0 g/kg/day in the human milk fed group and 4.4 g/kg/day in the formula fed group of infants. The concentrations of different metabolites were estimated at weekly intervals, and plasma amino acid analysis was performed biweekly on blood samples in the two groups of infants during the four-week study period. Formula milk fed infants had significantly lower fasting blood glucose levels and developed azotaemia, hyperaminoacidemia and metabolic acidosis in the early weeks of postnatal life. Blood lactate and plasma free fatty acid concentrations did not change significantly in the two groups during the study. No significant differences were found in the rate of weight gain between the two groups of infants, although formula fed infants regained their birthweight more slowly than human milk fed infants. High protein formula feeding causes potentially unfavorable metabolic and amino acid imbalances in preterm infants in the early postnatal life.

Amino Acids↗
PubMed1980

The distribution of Mycobacterium bovis in Queensland cattle herds with observations on the laboratory diagnosis of tuberculosis.

Of 1,791 tissues submitted from 1975 to 1978 for histological examination for tuberculosis, 78.5% were classified as tuberculosis, 8.1% as club-forming granulomas, 3.3% as hydatid cysts, 3.4% as other granulomas and 2.4% as squamous cell carcinomas. Cultural examination of 2,682 tissues for mycobacteria yielded Mycobacterium bovis from 42.88%, other mycobacteria from 7.64% and 0.89% Rhodococcus (Corynebacterium) equi. Of 1,478 tissues on which both examinations were performed, culture and histology results were in agreement on 94.1%. M. Bovis was isolated on one or more occasions from 564 herds with the highest herd prevalence being recorded in western areas of the state. Culture of 1,024 tissues from no visible lesion (NVL) reactors yielded 0.59% M. bovis, 15.04% other mycobacteria and 0.19% R. equi. Of 120 isolates of other mycobacteria from tissues of NVL reactors, 39 were Runyon Group III (20 M.avium complex) and 61 Runyon Group IV. Approximately half of the herds from which NVL tissues were collected were confirmed M. bovis infected properties.

Actinobacillosis↗
PubMed1980

Metabolic effects of septicaemia in newborn and young infants with particular reference to the plasma free amino acids.

Blood samples were obtained from 13 infants with clinically and microbiologically confirmed septicaemia. Two subgroups of the septic infants were formed according to postnatal age, an early onset group consisting of 6 infants younger than 7 days, and a late onset group comprising 7 infants of 20 infants. The blood samples were analysed for 18 plasma amino acids and glucose, lactate and FFA. Except the significantly lowered blood glucose in the early onset group of infants, no appreciable change occurred in the glucose, lactate and FFA levels. The plasma aminogram was different in the two groups, as hypoaminoacidaemia was more pronounced in the early onset group. The branched chain amino acids decreased significantly in both groups. The three important glucogenic amino acids alanine, glycine and proline showed a decrease only in the early onset group. Among the calculated plasma amino acid ratios the phenylalanine: tyrosine quotient was markedly increased. This, in addition to the response of the branched chain amino acids, has been found characteristic of a variety of clinical and experimental infections.

Alanine↗
PubMed1979

Diurnal variation in the quality and outcome of newborn intensive care.

Variables related to both the process and the outcome of neonatal intensive care were studied to compare care given during the day (0901-2100 hours) with that at night (2101-0900 hours). At night, intravenous infiltrations occurred more often, and the tidal volume of respirator-treated infants was verified less often. Blood pH values less than 7.20, excluding values within 12 hours of admission, were recorded more often and in more patients at night. During a 12-month period, there were significantly more deaths among infants less than 1,500 gm during the night than during the day. The deterioration of infants at night may result in part from current nursery staffing practices.

Birth Weight↗
PubMed1979

Gray-scale ultrasonography in the evaluation of neoplastic invasion of the base of the tongue.

Patients with primary carcinoma of the base of the tongue or direct invasion from contiguous areas were examined clinically and with ultrasound, and in some cases with computed tomography (CT), xerography, and polytomography. In all cases, multiple biopsy specimens were obtained. Utrasonography was better than the other imaging methods in delineating disease extent in the tongue itself, while CT and tomography were more useful in evaluating the retropharyngeal and lateral pharyngeal regions. It is suggested that ultrasound be used in the initial evaluation of such patients.

Aged↗
PubMed1979

Effect of hypothermia on plasma metabolites in preterm newborn infants with particular references to plasma free amino acids.

Blood glucose, blood lactate, plasma free fatty acids, plasma alpha-amino nitrogen, plasma free amino acids and blood urea nitrogen were measured in 15 hypothermic preterm infants (mean rectal temperature: 34.5 +/- 0.28 degrees C) during a 2-hour 'warming-up' period following admission to our neonatal intensive care unit. Hypothermia was associated with lactacidemia and hyperalaninemia. The increase in body temperature of the infants resulted in the decrease of lactacidemia and hyperalaninemia. Normal levels of other metabolites remained unchanged.

Amino Acids↗
PubMed1978

Transverse diameter of chest and heart after birth asphyxia in the newborn infant.

The transverse diameter of the chest and heart was measured in 745 newborn infants after birth asphyxia. Both diameters showed a good correlation with birth weight. The great individual variations of the measurements were due to different degrees of birth asphyxia observed in the infants and to their different responses to compensate asphyxia. A wet lung and an increased transverse diameter of the chest (above the 90th percentile) indicate a good, and a decreased transverse diameter of the chest (bellow the 10th percentile) indicate a bad prognosis for survival. The cardiomegaly usually disappears after the first 12 hours of life, but in some cases it persists for more than 5 days, depending on the severity of birth asphyxia.

Asphyxia Neonatorum↗
PubMed1978

Blood glucose and plasma amino acid concentrations in infants of diabetic mothers.

Postnatal blood glucose and individual plasma free amino acid levels were measured in 14 newborn infants of diabetic mothers. All infants had a significantly lower blood glucose concentration than normal controls but no significant correlation was observed between the blood glucose values and any of the amino acids determined. As regards the quantitative and qualitative changes of the plasma aminogram, the total concentration of amino acids and the level of a few individual amino acids (glycine, alanine, taurine, and valine) were significantly elevated in full-term babies. However, no significant difference was found in the total plasma concentration of amino acids between premature infants of diabetic mothers and premature control infants, but the plasma alanine level was higher in the former. It is of interest that total plasma amino acid, alanine, and glycine levels were elevated in the asphyxiated babies. This suggests that the postnatal hyperaminoacidemia observed in infants of diabetic mothers was due to birth asphyxia rather than to impaired gluconeogenesis. The possible role of a defective gluconeogenesis in the etiology of postnatal hypoglycemia in infants of diabetic mothers is not supported by these data.

Amino Acids↗
PubMed1977

Body size and neonatal hypoglycemia in intrauterine growth retardation.

The relationship between blood glucose and body physique of 233 (42 hypo-and 191 normologycemic) intrauterine growth-retarded neonates was analyzed using different body measurements and indices of body proportions. Classification by combination of weight and length deficit for fetal age revealed that the disproportionately retarded infants (deficit in weight for age > 30%; deficit in length for age less than equal to 15%) were particularly prone to hypoglycemia. The lowest incidence of hypoglycemia was observed in the group with severe proportionate retardation (weight deficit for age > 30%; length deficit for age > 15%). Among the indices of body proportions ponderal index (W/L3), and percentage deviation from the expected weight for length turned out to be a sensitive predictor of the risk of hypoglycemia. The majority of hypoglycemia neonates were underweight for length and a considerable number of normoglycemic infants were overweight for length. These findings point to the significance of soft tissue wasting rather than low birth weight for gestational age itself, in the development and diagnosis of neonatal hypoglycemia. The significance of anthropometry in the classification of different types of intrauterine growth impairment, as well as in predicting specific hazards after birth is discussed.

Anthropometry↗