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Biomedical subjects

K Schimrigk

Publications and source records attributed to K Schimrigk.

At least 163 records · Page 9Linked to original sources
PubMed1985

[Latency differences of visual evoked potentials in binocular and monocular checkerboard stimulation as well as age and sex dependence].

Pattern reversal evoked potentials (VEPs) have been recorded in 100 normal subjects with an average age of 37.6 years (range 11-69). We found significantly shorter latencies of the P 100 for binocular stimulation compared to monocular stimulation. Women under 50 years showed shorter latencies than men for both binocular and monocular stimulation. Men showed no significant latency dependence of age. However, women had a significant latency prolongation above an age of 50 years, indicating a sex specific influence on latencies.

Adolescent↗
PubMed1985

[Creatine kinase BB activity in the serum of patients with cerebrovascular diseases].

There are conflicting reports of an increase in the activity of creatine kinase BB isoenzyme (CK-BB) in the serum of patients with cerebrovascular disease. The serum CK-BB activity of 33 patients with ischemic brain infarction, subarachnoid hemorrhage or intracerebral hemorrhage was measured with a bioluminescence method (CK-B Kit, LKB-Wallac) in combination with immunoprecipitation. The results were compared with lesions determined by computed tomography. In the control group (N = 19) there was a mean activity of 0.35 +/- 0.26 U/l (means +/- SE). In patients with small lesions (N = 11) the activity was 0.41 +/- 0.21 U/l, which was not significantly elevated when compared to the control group (Mann/Whitney U test). Therefore, patients with more extensive lesions (N = 12) and the group with severe lesions (N = 10) showed a significant elevation, with a mean activity of 0.61 +/- 0.34 U/l and 1.12 +/- 0.52 U/l, respectively. The group with severe lesions had a maximum activity on the first day after the initial symptoms.

Adult↗
PubMed1984

Bicaudate diameter--the most specific and simple CT parameter in the diagnosis of Huntington's disease.

In addition to the neurological findings, the functional capacity of 12 patients with Huntington's disease was evaluated quantitatively according to the Shoulson and Fahn scale [1]. This parameter was related to the following computed tomographic measurements: the greatest distance between the frontal horns (FH), the shortest distance between the heads of the caudate nuclei (bicaudate diameter, CC) and the quotient FH/CC. The ratio of the bicaudate diameter and the external diameter of the skull across the narrowest point of the heads of the caudate nuclei (CC/OTcc) was also used as well as the bicaudate diameter and the maximum internal diameter of the skull (CC/ITmax). The best correlation was found between the bicaudate diameter and functional capacity (r = -0.64, P less than 0.05). All the quotients containing the bicaudate diameter likewise showed a correlation with functional capacity, though to a less marked degree. Thus the bicaudate diameter appears to be the most specific and simple computed tomographic parameter for the differentiation of Huntington's disease from normal states or choreatic syndromes of different origin.

Brain↗
PubMed1984

Centronuclear myopathy with special consideration of the adult form.

We report clinical, electrophysiological, enzyme histochemical and ultrastructural findings in 4 patients afflicted with centronuclear myopathy of adulthood whose disorder emphasizes the broad spectrum of this congenital myopathy including clear ocular ptosis in only one and facio-scapulo-peroneal syndrome in another patient. The morphological criteria for classification are central nuclei and the enzyme histochemical findings in muscle biopsies which did not show any significant progression over many years, more severe involvement of distal muscles in 2 patients and conspicuous presence of intrafascicular fat cells. 1 patient had associated minicores in a familial setting. Although electromyographic data comprised a mixed myopathic-neurogenic pattern, the morphological features in muscle biopsies did not further prove a neurogenic origin of our patients' neuromuscular disorder.

Adult↗
PubMed1983

Quantitative evaluation of functional capacity during isoniazid therapy in Huntington's disease.

Eleven patients with Huntington's disease were treated with high doses of isoniazid. In addition to clinical assessment, the functional capacity was evaluated quantitatively. The symptoms of four of the patients showed a marked improvement and their functional capacity increased. The condition of one patient with the rigid form (Westphal's variant) deteriorated, and the remaining six patients showed no change. Patients with prominent mental disturbances appeared to respond best to isoniazid therapy.

Adult↗
PubMed1982

Complications after combination of chemotherapy and radiation for malignant brain tumours.

The combination of chemotherapy and irradiation for the treatment of malignant intracerebral tumours is increasing, and survival times longer than those after monotherapy are reported. The suitability of simultaneous radio-chemotherapy using BCNU-Bleomycin, a regimen in which has been followed 38 patients of this hospital (up to 31 December 1981) is critically discussed. Statistics of 30 patients with treatment ended by 31 December 1980 and case histories of two patients with fatal complications, aspergillosis in the one and necrotizing colitis in the other, are presented. The value of the various agents used for chemotherapy is discussed with respect to the survival rates and observed side effects in all the patients. The use of Bleomycin is questioned.

Adult↗
PubMed1981

Malignant gliomas - glioblastoma multiforme and astrocytoma III-IV with extracranial metastases. Report of two cases.

The authors describe two rate cases of extraneural metastases of glioblastoma multiforme and of astrocytoma III-IV, but with different distribution routes. In the first case - astrocytoma III-IV - via the lymphatic system, with metastases in the cervical lymph nodes; in the second case-glioblastoma-via the blood system, with metastases in the sternum and vertebrae. Survival times were 18 months in the astrocytoma case (operation plus irradiation), and 6 months in the glioblastoma case (operation, irradiation, and chemotherapy). The discussion deals with the possible paths of the metastases, the connection between metastatic spread and survival time (in the longer surviving patient the metastases were discovered together with the recurrence), and problems in deciding the individual therapy.

Adult↗
PubMed1980

The touch corpuscles of the plantar surface of the big toe. Histological and histometrical investigations with respect to age.

Meissner's corpuscles of the plantar surface of the big toe of 30 persons were investigated histologically and histometrically with respect to age. The number of corpuscles decreases exponentially with increasing age. During the first decades of life the corpuscles exhibit a steady lateral and longitudinal growth. At an advanced age an atrophy of Meissner's corpuscles occurs. In spite of considerable individual variations, a distinct dependency on age can be noticed. Certain diseases, particularly disorders resulting in polyneuropathies, may initiate changes in the numbers and the structure of the corpuscles. Possible interrelationships between morphological neurophysiological and clinical findings are discussed.

Adolescent↗
PubMed1978

Parasitic myositis by Echinococcus alveolaris. Report of a family with myotonia congenita.

Echinococcus alveolaris infections were found in 5 members of a family and at least 3 of them also suffered from myotonia congenita. A muslce biopsy, performed in 1 case because of a pathological EMG finding allowed a diagnosis of parastic myositis caused by E. alveolaris to be made. In a further case, X-rays demonstrated calcification of an Echinococcus cyst in the thigh. Since is it only on rare occasions that these parasites are found in muscle tissue, factors are then discussed which might in some way be responsible for this high rate of E. alveolaris lesions in the muscles of patients with myotonia congenita.

Adolescent↗
PubMed1977

[Myositis].

Explore the source record for details and available documents.

Adult↗
PubMed1977

Myxedema myopathy: a case report.

A classical case of myxedema, demonstrating the typical Hoffmann syndrome (muscle weakness, hypertrophy, pseudomyotonic phenomena) and the usual rise in serum creatine phosphokinase (CPK), is discussed. Assuming that there is a CPK loss in the muscle fiber, the pseudomyotonic phenomena may be due to an increase in ADP, which in turn inhibits the calcium pump. Furthermore, light-microscopic and electron-microscopic findings are reported.

Adenosine Diphosphate↗
PubMed1977

The effect of electrical stimulation on the experimentally denervated rat muscle.

The m. quadriceps of white rats was electrically stimulated after nerve crush and after nerve section. Electrically stimulated muscles showed fewer central nuclei and a greater number of necrotic single fibres. The demonstration of motor endplates could not give a reliable indication of the onset of reinnervation. The various results show the importance of the trophic influence of the nerve and raise the suspicion that electrical stimulation has a retarding effect on the atrophy but also on regeneration of the fibres. After 7 weeks the unstimulated muscles show a greater degree of regeneration than the stimulated ones.

Animals↗