Biomedical subjects

K Satoh

Publications and source records attributed to K Satoh.

At least 1,351 records · Page 75Linked to original sources

PubMedDate not supplied

Perfusion, inhalation, and ventilation studies in patients with primary lung carcinoma.

To determine the relative roles of perfusion, inhalation, and ventilation lung scintigraphy, studies were done respectively in 48, 50, and 34 of 54 primary lung carcinoma patients (prior to thoracotomy and subsequent radical tumor resection). We observed the relationships between both the size of perfusion, inhalation, and ventilation defects observed scintigraphically, and the size of the mass lesion seen radiologically. We also estimated the correlation between those scintigraphic classifications and pTN. Although inhalation and perfusion images exhibited similar patterns, in hilar type lung carcinoma patients, the inhalation study showed superior mass lesion delineation. In peripheral type lung carcinoma, however, the incidence of negative inhalation defect (52%) differed significantly from that of negative perfusion defect (21%) (p less than 0.05). Xe-133 gas ventilation has limitations but is occasionally helpful in detecting obstructive airway disease. The coexistence ratio of COPD in lung carcinoma patients showed no significant difference from that of COPD in the controls. Perfusion and inhalation classification did not correlate with pTN factor.

Adenocarcinoma↗

PubMedDate not supplied

Effects of prophylactic irradiation of acute lymphoblastic leukemia in the central nervous system of children.

The development of prophylactic therapy for acute lymphoblastic leukemia (ALL) in the central nervous system in children has resulted in an improvement of the prognosis and prolongation of patients' lives. On the other hand, late irradiation effects have increased with the improvement of the prognosis. Therefore, there is now an important need to lessen these late effects without deteriorating the prognosis. We have investigated the recurrence rate, the survival rate and the cause of death of ALL patients who were divided into a none prophylactic irradiation group and 15 Gy, 20 Gy and 24 Gy irradiation groups. The results show that the effect of prophylactic irradiation has been more effective in the 20 Gy group than that of the 24 Gy group. Furthermore, brain atrophy and leukoencephalopathy, which were investigated by X-ray CT in long-term survivors of post-prophylactic irradiation without recurrence, have been less in the 20 Gy group than in that of the 24 Gy group. This report presents the result that the most favorable dose for prophylactic irradiation for central nervous system leukemia of ALL in children is 20 Gy by a step-up method.

Atrophy↗

PubMedDate not supplied

Experimental results with a whole body NMR-CT scanner using a resistive magnet.

A brief explanation is given on various advantageous features of NMR imaging methods for practical diagnostic purposes. A whole-body NMR-CT scanner utilizing a big resistive air-core magnet has been developed in cooperation with the Institute for Solid State Physics, University of Tokyo. This prototype NMR-CT scanner employs the projection-reconstruction-imaging method with a selective excitation technique for slicing. It can provide physicians with high quality proton NMR images within a practicable, acceptable short data-collection time. Typical NMR-CT images of healthy volunteers and patients were obtained in the experiments using this device, and are presented here. Although the images mainly reflect the hydrogen nucleus concentrations of the subjects, they are strongly affected by relaxation times T1 and T2 and also by the the subjects' internal and external bodily activities. The effects of various NMR parameters in the reconstructed images are analyzed and examples showing these parameter effects are demonstrated. Another advantage of NMR imaging shown here, is a sagittal image of a human body, which is difficult to obtain by using an X-ray CT scanner.

Abdomen↗

PubMedDate not supplied

Bronchial and vascular supply in azygos lobe of inflated fixed lung: a case study.

Azygos lobe is a comparatively rare anomaly of the lung, and its radiologic features are well known. However, reports concerning its bronchial and vascular supply are few. The authors describe the bronchial and vascular supply of an azygos lobe in the autopsied right lung of a 43-year-old man. In the inflated fixed lung, the azygos lobe was supplied by the bronchi of the apical sub-subsegmental branch of B1b (B1bi) and B1a (B1ai) accompanied by the accompanied by the pulmonary artery of the same sub-subsegments (A1bi, A1ai). The lateral sub-subsegmental branches of B1aii and B1bii accompanied by the pulmonary artery did not supply the azygos lobe. The azygos lobe was supplied by V1a. V2 but not V1b.

Adult↗

PubMedDate not supplied

The interaction between two antioxidants, sodium ascorbate and gallic acid: radical intensity and apoptosis induction.

ESR spectroscopy revealed that both the radical intensity and degradation rate of sodium ascorbate were increased with increasing pH. Gallic acid significantly reduced the radical intensity of sodium ascorbate, which in turn reduced the radical intensity of gallic acid. Sodium ascorbate inhibited the apoptosis-inducing activity of gallic acid, and gallic acid inhibited the intracellular incorporation of ascorbic acid. These data suggest that interaction between sodium ascorbate and gallic acid might modify their biological activity.

Antioxidants↗

PubMedDate not supplied

Effect of the type of serum in the medium on sodium ascorbate-induced cytotoxicity.

Sodium ascorbate induced cytotoxicity against human glioblastoma T98G cells in RPMI1640 medium supplemented with fetal bovine serum or human serum samples was studied. Several human serum samples significantly reduced the cytotoxic activity of sodium ascorbate, regardless of sex, age or the disease of the serum donor with or without heat-inactivation of the serum. ESR spectroscopy revealed that this serum effect was not simply due to the alteration of the ascorbyl radical intensity, produced from sodium ascorbate. The present study suggests that the apoptosis-inducing activity of sodium ascorbate might be significantly affected by human serum.

Adult↗

PubMedDate not supplied

Superselective angio-CT of brain tumors.

PURPOSE: To determine the efficacy of superselective angio-CT in the diagnosis of astrocytoma. METHODS: Nineteen patients with astrocytoma had superselective angio-CT before chemotherapeutic agents were administered via superselective intraarterial infusion. CT was performed after contrast material was delivered through a microcatheter, which had been advanced into the feeding arteries of the tumor. Superselective angio-CT scans were compared with digital subtraction angiograms, conventional contrast-enhanced CT scans, and contrast-enhanced T1-weighted MR images. RESULTS: Superselective angio-CT scans depicted contrast enhancement of the tumor in all of the patients and the medullary veins of the tumors in 32% of the patients. Digital subtraction angiograms showed tumor stains in 68% of the patients and the medullary veins in only 5%. Conventional CT scans and MR images showed contrast enhancement of the tumor in 89% of the patients. Superselective angio-CT scans confirmed the proper position of the catheter tip for the infusion of a chemotherapeutic agent. CONCLUSIONS: Superselective angio-CT can be used to depict contrast enhancement of tumors and the vascular structures that are characteristic of astrocytomas.

Adult↗

PubMedDate not supplied

Transvenous embolization of high flow carotid cavernous fistula: a case report.

We treated a patient with a high flow traumatic carotid-cavernous fistula (CCF) by embolization using detachable balloons and metallic coils, by transarterial and transvenous approaches. The patient was a 20-year-old woman who had fractures in the skull base from a traffic accident. She was admitted to our hospital one month after the accident due to exophthalmos, chemosis, and periorbital bruit. Cerebral angiograms demonstrated left traumatic CCF and steal phenomenon of blood flow. Balloon embolization by transarterial approach performed three times was unsuccessful, probably because of balloon puncture due to bone fragments. Embolization using metalic coils via the superior ophthalmic vein route was then attempted. As a result of this approach, complete obliteration of CCF was obtained, and clinical symptoms subsided within a few days. Treatment of CCF by transvenous approach is one alternative when transarterial occlusion is difficult.

Adult↗

PubMedDate not supplied

CT-pathologic correlation in the tumor margins of lung cancer.

A CT-pathologic correlative study concerning the nature of the tumor margin was performed in 22 lung cancer cases with solitary nodules in the peripheral lung field. Three of 14 adenocarcinoma cases showed an ill-defined margin and an adjacent subtle high attenuation area on CT, representing alveoli lined by tumor cells. In the other 11 cases, both ill- and well-defined margins were seen on CT. A well-defined margin of the mass represented alveoli filled entirely with mucinous material or tumor cells. In three of six squamous cell carcinomas an ill-defined margin in CT represented the infiltration of lymphatic cells surrounding the tumor and continuous spread of tumor cells from neighboring alveoli. A well-defined margin in the other cases and two small cell carcinoma cases represented alveoli filled entirely with tumor cells. CT was shown to be very useful in the assessment of the nature of the margin of the tumor.

Adenocarcinoma↗

PubMedDate not supplied

Relationship between ascorbyl radical intensity and apoptosis-inducing activity.

Ascorbic acid and its related compounds were compared for their ascorbyl radical intensity and apoptosis-inducing activity. Sodium L-ascorbate, L-ascorbic acid, D-isoascorbic acid, sodium 6-beta-O-galactosyl-L-ascorbate and sodium 5,6-benzylidene-L-ascorbate, at the concentration of 1-10 mM, induced apoptotic cell death characterized by cell shrinkage, nuclear fragmentation and internucleosomal DNA cleavage in human promyelocytic leukemic HL-60 cells. On the other hand, L-ascorbic acid-2-phosphate magnesium salt and L-ascorbic acid 2-sulfate did not induce any of these apoptosis-associated characteristics. ESR measurements revealed that all the active compounds were progressively degraded, producing the ascorbyl radical (g = 2.0064, hfc = 0.17 mT) in culture medium, whereas the inactive compounds were stable and did not produce the ascorbyl radical. Cytotoxicity began to appear when the radical intensity exceeded a certain threshold level. In the presence of N-acetyl-L-cysteine, both ascorbyl radical intensity and apoptosis-inducing activity were significantly reduced. These data suggest the possible involvement of the ascorbyl radical in apoptosis induction by ascorbic acid-related compounds. Exposure of HL-60 cells to ascorbic acid or its active derivatives resulted in the rapid elevation of intracellular Ca2+ concentration, which might serve as the initial signal leading to the cell death pathway.

Antineoplastic Agents↗

PubMedDate not supplied

Stimulation of two step degradation of sodium ascorbate by lignins.

Alkali-lignin stimulated the degradation of sodium ascorbate in phosphate-buffered saline, fetal bovine serum and culture medium, but not in distilled water. ESR spectroscopy revealed that alkali-lignin stimulated ascorbyl radical production even in distilled water. Similar stimulation activity was found in several other plant extracts, commercial and natural lignified materials. These data suggest that the lignin-stimulated degradation process of ascorbate might be separated into two processes, the first being the ascorbyl radical production process and the second the degradation process.

Animals↗

PubMedDate not supplied

Ascorbyl radical scavenging activity of polyphenols.

A variety of tannin and lignin-related compounds were compared for their ability to modify the ascorbyl radical intensity of sodium ascorbate. Hot-water extracts prepared from green tea, black tea and pine cone (Pinus parviflora Sieb. et Zucc.), and various wines potently scavenged ascorbyl radical intensity. Low molecular weight tannins and phenylpropenoid monomers showed the greatest scavenging activity, whereas the dehydrogenation polymers of phenylpropenoids were much less active. On the other hand, natural lignified materials, protein-bound polysaccharide (PSK) and positively-charged glucans enhanced the ascorbyl radical intensity. Lignin sulfonate stimulated the sodium ascorbate-induced cytotoxicity in human promyelocytic leukemic HL-60 cells. These data suggest that the ascorbyl radical scavenging activity of polyphenols depends on molecular weight, the functional group and the presence of polysaccharides in the molecule.

Ascorbic Acid↗

PubMedDate not supplied

Enhancement of radical intensity and cytotoxic activity of ascorbate by PSK and lignins.

ESR spectroscopy revealed that high molecular weight natural substances, such as protein-bound polysaccharide PSK, alkali-lignin and lignin sulfonate, significantly enhanced the ascorbyl radical intensity derived from sodium ascorbate or ascorbic acid in culture medium. Enhancement of the ascorbyl radical intensity was coupled with rapid degradation of ascorbate. These substances synergistically enhanced the ascorbate-induced cytotoxicity against human leukemic and glioblastoma cell lines. These data suggest the possible role of the ascorbyl radical in cytotoxicity induction.

Ascorbic Acid↗

PubMedDate not supplied

Enhancement of radical intensity and cytotoxic activity of ascorbate by hyperthermia.

ESR spectroscopy revealed that the radical intensity of sodium ascorbate and ascorbic acid was significantly higher under hyperthermic conditions. The enhancement of ascorbyl radical intensity was coupled with the accelerated degradation of ascorbate and cytotoxicity induction against human leukemic and glioblastoma cell lines. Sodium ascorbate produced higher ascorbyl radical intensity and more potent cytotoxicity, as compared with ascorbic acid. These data demonstrate that ascorbic acid does not inhibit, but rather stimulates the cytotoxic action of hyperthermia. The combination of hyperthermia and ascorbate treatment might produce higher antitumor activity.

Ascorbic Acid↗

PubMedDate not supplied

Radiologic manifestation of spinal accessory neurinoma: a case report.

Spinal accessory nerve neurinoma is very rare; only 12 cases have been reported in the literature. We describe a 54-year-old woman who had a cisterna magna tumor expanding extracranially to the C1 cervical body. The tumor originated from the spinal root of the right accessory nerve. The radiological features including CT, MRI, and angiography are discussed. There have been reports on cranial MRI studies of spinal accessory neurinoma. MRI suggested an extra-axial tumor. The histological diagnosis was mixed Antoni A and B neurinoma. The neuroradiological findings of 12 cases of neurinoma of the accessory nerve reported in the literature are reviewed.

Accessory Nerve↗

PubMedDate not supplied

Expression of CD44 in duct cell carcinomas and in intraductal neoplasms of the pancreas.

The expression of alternatively spliced CD44 isoforms, especially so-called variant exons v5 and v6, has been shown to correlate with the progression of a number of human cancers examined the expression of standard CD44 and CD44 variants with exons v5 and v6 in 28 cases of human pancreatic tumors (16 cases of invasive duct cell adenocarcinoma and 12 cases of intraductal neoplasms) by immunohistochemistry using exon specific monoclonal antibodies. The expression of standard CD44 was frequently observed in both invasive duct cell carcinomas and intraductal neoplasms. The expression of CD44 variants (v5 and v6) was also seen in almost all duct cell carcinomas. In contrast, intraductal neoplasms infrequently expressed CD44-v5 and -v6, particularly v6 exon. Expression of CD44-v5 and v6 was a common characteristic of invasive cancer, while it was not so prominent in intraductal neoplasm. These findings may be related to the invasiveness of duct cell carcinoma and/or the benign biological behavior of intraductal neoplasm of the pancreas.

Carcinoma, Ductal, Breast↗

PubMedDate not supplied

Prooxidant action of two antioxidants: ascorbic acid and gallic acid.

The addition of two antioxidants, ascorbic acid or gallic acid to distilled water resulted in the rapid increase in the reduction potential, which a few seconds later was replaced with much higher oxidation potential. The addition of these compounds to culture medium dose-dependently increased the oxidation potential only. Ascorbic acid analogs, which had apoptosis-inducing activity, showed similar oxidation potential, whereas inactive analogs did not. The combination of ascorbate and hydrogen peroxide additively enhanced both the oxidation potential and cytotoxic activity. These data demonstrate that both ascorbic acid and gallic acid act as prooxidants for the induction of apoptotic cell death.

Antioxidants↗

PubMedDate not supplied

Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis.

Gallic acid induced apoptotic cell death in human promyelocytic leukemia HL-60 cells. The effect of gallic acid was significantly reduced by blocking the free hydroxyl or carboxyl group with acetyl, methyl, ethyl, n-propyl or isoamyl group. This was paralleled with the decrease in the intensity of both gallate radical and oxidation potential. These data suggest the prooxidant action of gallic acid in the induction of apoptosis. On the other hand, the introduction of larger alkyl groups, such as lauryl or stearyl groups, to the carboxyl group of gallic acid, neither increased the radical intensity nor oxidation potential, but significantly increased its apoptosis-inducing activity. This suggests that the increase in the lipophilicity of the gallate molecule is an another factor which induces apoptosis by an as yet unidentified mechanism.

Antioxidants↗