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Biomedical subjects

K Sanada

Publications and source records attributed to K Sanada.

At least 91 records · Page 5Linked to original sources
PubMed1981

Umbilical venous-arterial differences of plasma amino acids in humans at midpregnancy.

The plasma levels of 20 free amino acids in the umbilical vein (UV) and the umbilical artery (UA) of seven newborns (20-24 weeks gestation) were measured at delivery. Seven (lys, val, leu, thr, his, ile, phe, and met) of the essential amino acids and six [ala, glu (NH2), arg, pro, 1/2 cys, and asp (NH2)] of the nonessential amino acids were shown to be significantly higher in UV than in UA. Among these amino acids, alanine showed the largest value for umbilical venous-arterial difference (UV-UA). Total plasma amino acid concentration was shown to be higher in the UV than in the UA. The general pattern of UV-UA for plasma amino acids in newborns studied here was proven to resemble closely that of premature births reported earlier.

Amino Acids↗
PubMed1980

The amino acid sequence of a salivary proline-rich peptide, P-C, and its relation to a salivary proline-rich phosphoprotein, protein C.

A basic proline-rich peptide, P-C, was isolated from human whole saliva and its amino acid sequence was determined to be Gly-Arg-Pro-Gln-Gly-Pro-Pro-Gln-Gln-Gly-Gly-His-Gln-Gln-Gly-Pro-Pro-Pro-Pro-Pro-Pro-Gly-Lys-Pro-Gln-Gly-Pro-Pro-Pro-Gln-Gly-Gly-Arg-Pro-Gln-Gly-Pro-Pro-Gln-Gly-Gln-Ser-Pro-Gln. P-C was also found to be present in stimulated parotid saliva. The sequence determined appears to correspond to the C-terminal 44 residues of a proline-rich phosphoprotein, Protein C, the partial sequence of which has been elucidated, and suggests that P-C might be derived from Protein C.

Adult↗
PubMed1979

Isolation and amino acid sequences of proline-rich peptides of human whole saliva.

Three basic peptides with extremely high proline contents were isolated from human whole saliva. The amino acid sequences of two of these proline-rich peptides comprising 57 and 38 residues were determined by conventional methods. The sequence suggested that the smaller peptide was derived from the larger one and also revealed the occurrence of characteristic repeating units within the molecules. The present study is the first to describe this structural feature of proline-rich proteins or peptides.

Adult↗
PubMed1978

Umbilical vein-artery differences of plasma amino acids in the last trimester of human pregnancy.

The plasma levels of 20 free amino acids in the umbilical veins and umbilical arteries of 8 premature (29--36 weeks gestation) and 16 mature (38--42 weeks gestation) newborn infants were measured at delivery. In premature newborn infants, most of the 20 amino acids were significantly higher in the umbilical vein than in the umbilical artery. Only glutamic acid was significantly lower in the umbilical vein than in the umbilical artery. In mature newborn infants, 7 (Ala, Lys, Leu, Val, Ile, Phe and His) of the 20 plasma amino acids were significantly higher and 4 (Glu, Gly, Ser and Orn) were significantly lower in the umbilical vein than in the umbilical artery. These results indicate that the relative contribution of individual amino acids to the placental supply of nitrogen to the human fetus discernibly changes with increasing fetal age during the last trimester of gestation.

Amino Acids↗
PubMed1978

Practical use of swan-type double-bending gastrofiberscope.

After devising remote-controlled angle to gastrofiberscope in 1964, the authors invented a swan-type double-bending gastrofiberscope in 1967. The double-bending gastrofiberscope does not require any change in a patient's position, for the motion of the tip is sufficient to observe every part of the stomach on supine position. In order to relax the patient both physically and mentally, relaxation of the patient is obtained by taking off this excessive attention on the endoscopic examination. Clear visual field can be obtained at the moment when the fiberscope passes the cardia, by stopping the scope just above the cardia and inflating sufficient air, and then, inserting the scope with the lens directed to the anterior wall of the greater curvature. Several marks are put on the body of the scope, as a functional scale, which makes its handling easier.

Cardia↗
PubMed1975

Findings with swan-type double-bending gastrofiberscope.

By using the swan-type double-bending gastrofiberscope, it has become very easy to observe such regions as the cardia, posterior wall of the upper corpus or the pyloric region. The authors can obtain a clear image of the cardia, especially the form of the fold of the region or the esophagogastric junction. The authors recognized that the form changes according to the amount of the inflated air, and the insufficient function of the cardia can be easily diagnosed. The degree and form of the elevation of the posterior wall of the upper corpus of the stomach was observed and classified into three types, flat type, slightly elevated type and highly elevated type. Pathological deformation of this region was studied from the shape of this elevation. By the close observation of the pyloric region, it was clarified that the appearance of the folds may be radiated, transverse at the lesser curvature or entirely lost, being closely related to the presence of the erosions in this region. The healing process of the gastric ulcer was examined endoscopically from the viewpoint of the radiating vessel zone and contraction by the scar. When the capillary vessels are the more prominent finding of a healing ulcer, it tends to form a surface possessing a scar after it is healed and when the contraction is more prominent, it tends to form a linear scar after healing. By the recrudescence of the gastric ulcer, the irregular capillary vessels or deviation of the convergence of the folds are observed, and by the recurrence of the ulcer, coexistence or completion of a scar is observed.

Cardia↗