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Biomedical subjects

K Sameshima

Publications and source records attributed to K Sameshima.

27 records · Page 2Linked to original sources
PubMed1990

Connection, a microcomputer program for storing and analyzing structural properties of neural circuits.

The application of a microcomputer-based system (the Connection system) designed to deal with neuroanatomical information commonly analyzed by researchers and involved in the study of structural properties of neural circuits is presented. This system can be employed at first as a readily-accessible database containing physiological and anatomical data from nuclei of the central nervous system which define a network with up to 45 elements and their subdivisions and connections. Once the database from a specific network is built and stored in a file, routines of this system can be used to classify the nuclei in term of their afferents and efferents and also to display all possible pathways linking any pair of nuclei and their respective length (number of synapses). The role of such a system as an auxiliary tool in neuroanatomical and electrophysiological research is discussed by presenting the results obtained from the analysis of the neural circuits involved in cardiovascular function control in higher vertebrates.

Algorithms↗
PubMed1990

[Reproductive and developmental toxicity study of mofezolac (N-22) (3)--Teratogenicity study in rabbits by oral administration].

Mofezolac (N-22) is a new developed analgesic and anti-inflammatory agent. A teratogenicity study of N-22 was carried out in New Zealand White rabbits to examine the effect on the dams and the teratogenic potentiality. N-22 was administered orally at the dose levels of 12.5, 50 and 200 mg/kg during the organogenesis from day 6 to day 18 of gestation. All pregnant females were sacrificed on day 28 of gestation and their fetuses were examined. There were no growth retardation and teratogenic effects on fetuses from the dams administered N-22, although the administration of 200 mg/kg produced a decrease in food consumption of the dams concomitant with the embryocidal effects as shown by an increase in the early resorption rate. Thus, non-toxic dose level of N-22 on the dams and fetuses was considered to be 50 mg/kg.

Abnormalities, Drug-Induced↗
PubMed1990

Electrical activity of the posterior thalamic nucleus and the hippocampus during wakefulness and desynchronized sleep in the rat: a spectral analysis.

The electrical activity of the posterior thalamic nuclear complex was studied in rats and related to the simultaneous hippocampal electro-oscillogram. Electrocorticographic tracings and spectral analysis showed that during attentive wakefulness the electro-oscillogram peaked at 8 Hz and in desynchronized sleep it oscillated at regular frequencies between 8 and 9 Hz. In quiet wakefulness, frequency was lower (around 6 Hz) and during synchronized sleep rhythmicity disappeared. The electrophysiological patterns during wakefulness and desynchronized sleep are proposed to be linked to the retrieval and combination of information for the generation of attention and dream content.

Animals↗
PubMed1990

Stationarity and normality of distribution of rat cortical brain waves.

Establishing the stationarity and statistical distribution of potentials recorded from the nervous system is crucial for the application of frequency analysis. Both parameters were determined in the electrocorticograms of six adult Wistar rats during wakefulness and desynchronized sleep, during both of which desynchronization prevails. Stationarity of the signals was found to occur during at least 20 s in both states of the wakefulness-sleep cycle. A normal distribution was also found for at least 6.7 s. These findings provide strong support for the use of frequency analysis of brain waves as a reliable method to quantify neural electro-oscillograms.

Animals↗
PubMed1989

[Two cases of amylase-producing lung cancer].

In 1951, Weiss et al. first reported a case of an amylase-producing lung cancer. Since then, reports on immunohistochemical, ultrastructural, and biochemical studies have been published. We recently have experienced two autopsy cases of lung cancer that manifested high amylase activity in the serum, urine, and pleural effusions. Histologically, both lung cancers were classified as being well differentiated adenocarcinomas, and immunohistochemically, the tumor cells showed positive immunoreactivity for amylase. This paper discusses the histogenesis of amylase-producing lung cancers and cases found in the literature.

Adenocarcinoma↗
PubMed1988

Cleft hand in Silver-Russell syndrome.

A case of Silver-Russell Syndrome with a typical cleft hand is presented. The association of cleft hand with this syndrome has never been reported before.

Child↗
PubMed1988

16q21 is critical for 16q deletion syndrome.

A 1-year-old girl with an interstitial deletion of the long arm of chromosome 16 is reported. She was characterized by a distinct craniofacial dysmorphism, meningoencephalocele, mild hydrocephalus, short neck, broad great toes and abnormally positioned toes. High resolution GTG and RBG banding analyses revealed a karyotype: 46,XX,del(16) (q13q22) de novo. An analysis of the smallest region of overlap revealed that the critical band region for 16q deletion syndrome is 16q21.

Abnormalities, Multiple↗