Late appearance of resistance to tumor rechallenge following cryosurgery. A study in an experimental mammary tumor of the rat.
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Biomedical subjects
Publications and source records attributed to K Sakata.
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Genetic polymorphism of human plasminogen in the Japanese population was studied using agarose gel isoelectric focusing followed by immunofixation. A new basic variant, PLG B, was found as a heterozygous state PLG 1-B, which was genetically determined. The allele frequencies calculated from 258 individuals were PLG1=0.958, PLG2=0.020 and PLGB=0.022.
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A close resemblance in fine structure was observed between the aganglionic colon, produced in rats by serosal application of 0.1% benzalkonium chloride solution, and the aganglionic descending colon, or more proximal segments, of Hirschsprung's disease. The pathogenesis of the disease is discussed.
A survey was made of 112 cases of gallstone ileus reported in the Japanese literature, including 3 of our cases. The ratio of males to females was 1 to 1.1, the age range was 13 to 87 years, and biliary-enteric fistulas were demonstrated in 81 percent of the patients. Although cholecystoduodenal fistula was most common, eight cases of choledochoduodenal fistula were reported. Sixteen patients passed obstructing gallstones through a patulous sphincter of Oddi. The ileum was occluded in 54 percent of the cases. Duodenal obstruction was seen in 10 percent. There was no operative mortality in seven patients treated with enterolithotomy, subsequent cholecystectomy and repair of the fistula, whereas a mortality rate of 19 percent followed the one-stage procedure.
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Recently, a case of intracranial germinoma in the right basal ganglia was experienced in our department. He was a 14-years old boy with left motor hemiparesis. On repeated CT studies (7 times), developmental process of the tumor was observed for about 2 years. The tumor developed from the right putamen and invaded toward it's neighboring area (right basal ganglia, thalamus and hypothalamus). As the tumor grew larger, multiple cysts were formed in the tumor tissue and dislocation of ventricles occurred. On 21 December 1978, right temporal craniotomy was performed and a piece of the tumor was removed. It's tissue was diagnosed as germinoma by pathohistological examination. As the effect of postoperative 60Co irradiation and chemotherapy (Vicristine, CCNU), tumor stain (high density area) on CT scann disappeared and remained only as a well margined low density area. On CT scan in September 1979, recurrence sign was not noted. Clinical features of the germinoma located in the basal ganglia has not been well known, because of it's rarity. As a result of the survey of 7 cases reported in the Japanese literature and our case, it has been made clear that most of them are characterized by motor hemiparesis in the early stage, not accompanied by intracranial hypertension.
Intestinal aganglionosis produced by serosal application of 0.1% benzalkonium solution to the colon of the rat was studied electronmicroscopically, and it was concluded that a higher susceptibility to the agent and a lower recovering ability of the nerve elements might be responsible for the phenomenon.
3 infantile cases of congenital parieto-occipital midline soft tumor, the clinical and pathological findings of which did not correspond precisely to a known congenital head tumor, are reported. One of them probably belongs to McLaurin's type of encephalocele with heterotopic glial rest, and the remaining two to McLaurin's type of meningocele without central connection. The types of anomaly shown by the present cases should generally be called 'atretic cephalocele' or 'rudimentary cephalocele'.
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For the identification of a peptidyl principle inducing sexual agglutination in the yeast, 2 supposed hexapeptides (1a, b) were synthesized by the conventional method. The 1a (H-Arg-Gly-Pro-Phe-Pro-Ile-OH) revealed complete identity with the natural peptide in TLC, MS and biological property on agglutination. The 1b showed the sexual agglutinability in the same degree as 1a, though distinct differences were observed in the chemical data. Both 1a and 1b had a strong bitter taste.