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Biomedical subjects

K Rotter

Publications and source records attributed to K Rotter.

11 recordsLinked to original sources
PubMed2001

Stereotactic breast biopsies: analysis of needle deviation based on stereotactic views.

Stereotaxy is widely used for breast biopsy and needle localization of mammographically detected lesions. If a lesion shift occurs during stereotaxy, corrections (even though possible with vacuum biopsy) is difficult due to the difficult assessment of the exact 3D shift. In this study we investigated the correlation between lesion shift (in up to three dimensions) and its visualisation on the stereotactic images (0 degree, -15 degrees, +15 degrees). The study was performed on a Fischer prone table (Fischer Imaging Europe, Vejle, Denmark) using a 3.8-mm steel ball (as lesion) and a 20-G needle. The 17 major malpositions of the ball with respect to the needle were imitated and imaged. A simple rule is suggested as to how the deviation in all three dimensions can be detected from the scout and the two stereotactic views. The rule proved to be a valuable tool to correctly assess lesion shifts.

Biopsy, Needle↗
PubMed1998

[Therapeutic efficacy of low-dose alpha interferon therapy in liver cirrhosis associated with HBV].

The aim of this study was the assessment the efficacy and safety of therapy with interferon alpha (Intron A) administered s.c. 3 MU x 3/week for 12 weeks for patients with HBV related liver cirrhosis (Child's class A). Fifteen patients completed therapy and 12 months follow-up. At the end of follow-up sustained response to the therapy, defined by clearance of HBV-DNA, normalization of ALAT activity in serum and improvement in the liver histology was achieved in 46.6% of treated patients. Moreover, among few patients from group of nonresponders (patients without sustained clearance of HBV-DNA) decrease of HBV-DNA level, ALAT activity in serum and improvement in the liver histology were observed. Adverse effects of IFN alpha therapy were typical, but in any case were no necessity terminate the therapy.

Adult↗
PubMed1995

[Plasma fibronectin in chronic liver disease--marker of fibrosis?].

The determination of fibronectin (FN) concentration in plasma has been performed in the group of 77 patients (60-with various chronic liver diseases, 6-with AIDS IVc, 11-healthy patients). The purpose of this study was: evaluation of the value of plasma FN determination in assessment the degree of liver fibrosis and the degree of liver damage. The obtained results were compared with routine biochemical tests and histopathological picture of liver sections. Among patients with liver diseases, we observed that plasma FN concentration was significantly lower only in the group with decompensated liver cirrhosis, in relation to control group. Non significant lower values of FN was observed in the group of patients with chronic hepatitis, as well as non significant higher ones in the group with cholestasis and fibrosis. It has been concluded that determination of plasma FN concentration has not any importance in evaluation of degree of liver fibrosis and its only one from many functional liver tests.

Acquired Immunodeficiency Syndrome↗
PubMed1992

[Evaluation of treatment outcome for bacterial meningitis and encephalitis at the provincial hospital of infectious diseases in Wrocław during 1985-1989].

Data about 848 patients treated in the years 1985-1989 in the Province Hospital of Infectious Diseases were analyzed. Among them were 98 patients with bacterial meningitis and encephalitis. The most frequent etiological agents were Neisseria meningitidis and Diplococcus pneumoniae. In none case Haemophilus influenzae was isolated. The average time of hospitalization was limited to 45 days. Treatment introduced at once was based on the results of bacteriological tests. Crystalline penicillin, cephalosporins of the II and the III generation and in some cases metronidazole were antibiotics of choice. Serious complications were observed in 25% of patients. 5% of patients died.

Adolescent↗
PubMed1978

Tympanoplasty.

Explore the source record for details and available documents.

Chronic Disease↗
PubMedDate not supplied

Selective procedure to isolate haemophilus influenzae from sputa with large quantities of Pseudomonas aeruginosa.

The identification of respiratory pathogens (e. g. Haemophilus influenzae, Streptococcus pneumoniae) is impaired by the presence of large quantities of Pseudomonas aeruginosa, as is the case in the sputum specimens of cystic fibrosis patients. A procedure has been evaluated whereby the selective inhibition of the proliferation of P. aeruginosa is achieved by a broad spectrum pyocin, whereas the growth of H. influenzae is not influenced. This technique has been tested over a two year period resulting in a significantly augmented rate of identification of H. influenzae.

Bacteriocins↗
PubMedDate not supplied

HBV-DNA level in blood serum as a predictor of good response to therapy with interferon-alpha-2b of patients with chronic hepatitis B.

The prevalence of hepatitis B infection in population in Poland is low and averages 1-1.5%. However, it means that about 380,000 Poles constantly or temporarily replicate HBV. Chronic HBV infection is associated with increased risk of serious liver diseases and it is estimated that 25-40% of patients with chronic hepatitis B will die prematurely of cirrhosis or primary liver cancer. Up to the present, interferon-alpha (IFN-alpha), with low response rate between 25-55% and some limitations of therapy, has been the only available treatment for chronic hepatitis B. A favorable outcome of IFN-alpha therapy is associated with some prognostic factors, not accepted by all investigators, such as low level of HBV-DNA in serum. The aim of this study was to assess the efficacy of therapy with IFN-alpha 2b (Intron A), administered s.c. 5 MU x 3/week for 16 weeks, in 65 patients with chronic hepatitis B, divided into groups according to the baseline HBV-DNA level. Except for serum HBV-DNA level, there were no demographical and biochemical differences between all the treated groups. The patients were followed-up for 12 months. Sustained response (SR) to the therapy (defined as ALAT normalization, loss of detectable HBV-DNA, seroconversion HBeAg to anti-HBeAg and improvement in liver histology) was observed in 16 (57.14%) of patients in the group with HBVDNA level < 1000 pg/ml, in 6 (37.5%) with HBV-DNA level of 1001-3000 pg/ml, in 4 (28.57%) with HBV-DNA level of 3001-5000 pg/ml and only in 2 (28.57%) of patients in group with HBVDNA level > 5000 pg/ml. We conclude that IFN-alpha is particularly useful in therapy of patients with chronic hepatitis B with low levels of HBV-DNA. The baseline HBVDNA level < 1000 pg/ml in serum is the predictor of good response to IFN-alpha therapy.

Adolescent↗