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Biomedical subjects

K Rommel

Publications and source records attributed to K Rommel.

At least 55 records · Page 3Linked to original sources
PubMed1975

Effect of secretin on intestinal monosaccharide absorption and new water movement in the rat.

Repeated intravenous injections of 2.0 clinical units (CU) secretin per kg body weight showed no effect on jejunal glucose absorption and net water movement in perfusion studies in vivo. The in vitro uptake of galactose and 3-O-methylglucose was not altered by a secretin load given 12 min before sacrifice. The values for Km and Vmax were identical after secretin and in a control group. The conflicting results of different authors concerning the effect of secretin on net water movement and solute absorption may be due to differences in experimental techniques, different, mostly pharmacological doses of the hormone, and a diverse response of heterogeneous species.

Animals↗
PubMed1975

Absorption of short and medium chain fatty acids in the jejunum of the rat.

The uptake of the shortest six fatty acids (acetic to octanoic) was studied in vitro, using everted segments of rat jejunum. The marked influence of medium-pH and fatty acid chain-length suggests that non-ionic diffusion through the lipoid membrane is quantitatively the most important way of transport, but ionic diffusion through the membrane as well as transport through hydrophilic pores also seem to play a role. Though fatt acids evidently are accumulated in the tissue-fluid, and saturation kinetics, competitive inhibition and sodium- as well as energy-dependence apparently are observed, the transport mechanism is assumed to involve solely passive diffusion, - the concept of a carrier-mediated transport for short and medium chain fatty acids seems improbable.

Animals↗
PubMed1975

The behaviour of different markers of the mucosal extracellular space in rat small intestine.

The mucosal extracellular space in rat small intestine is determined with inulin-14C, mannitol-14C and unlabeled 2-deoxy-D-glucose in control animals and after an intravenous secretin load. The mannitol and 2-deoxy-D-glucose spaces in control animals are significantly greater than the inulin space. After secretin the three investigated markers show different, in part adverse, alterations of the mucosal extracellular space. These different results may be due to the composition of the incubation medium and to a distinct effect of secretin on the distribution of the employed markers.

Animals↗