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Biomedical subjects

K Robinson

Publications and source records attributed to K Robinson.

At least 289 records · Page 16Linked to original sources
PubMed1977

Treatment of the premenstrual syndrome.

A placebo-controlled, randomized, double-blind, parallel group study in hospital and general practice has shown that a combination of belladonna alkaloids, ergotamine tartrate, and phenobarbitone (Bellergal) was effective in treating troublesome symptoms of the premenstrual syndrome of which fatigue, tender breasts, nervousness, irritability, lethargy and listlessness were improved to a statistically significant degree. The drug was given three times daily and caused no side effects.

Adolescent↗
PubMed1976

Determination of therapeutic serum concentrations of oral and parenteral meperidine by liquid chromatography.

A sensitive and specific method for estimation of serum meperidine by gas-liquid chromatography and its application in a clinical study are described. Patients were given, under double-blind conditions, either oral (75 or 150 mg) or intramuscular (50 or 100 mg) doses of meperidine for postoperative analgesia. Serum meperidine levels were measured 0.5, 1, 2, 3, and 4 hours post-dose. Although wide variations of serum meperidine levels were observed among individuals within each group for each time period, the intramuscular route produced and sustained significantly higher serum levels than did the oral route. The mean concentration of meperidine (mug/100 ml +/- S.E.) for 100 mg i.m. was 37.7 +/- 3.8 at one hour and 23.4 +/-5.7 at three hours; for 150 mg orally it was 11.9 +/- 1.6 at one hour and 11.8 +/- 3.2 at three hours. A correlation observed between the intramuscular dose (in mg/kg body weight) and serum meperidine concentration attained at one hour indicated that 1 mg/kg meperidine i.m. will achieve a one-hour serum level of approximately 20 mug/100 ml, an apparent minimally effective level for analesia in most patients.

Administration, Oral↗
PubMed1976

Intraoral-mucosal-xenogenous fascial grafting.

Fascia obtained from the abdominal wall of a rat was transplanted into mucosal defects created in six dogs. In all of the dogs, the fascia was found to adhere firmly to the underlying tissue and surrounding epithelium. Biopsy specimens were taken at weekly intervals for 4 weeks. The defects healed without any apparent contracture and were covered by new epithelium. It appears that xenogenous fascia is a potentially useful graft material for intraoral soft tissues.

Animals↗
PubMed1976

PTA deficiency (factor XI deficiency). Report of a case.

A case of a relatively rare coagulopathy has been presented. The mode of inheritance and the incidence of the disease have been discussed. Methods of screening, diagnosis, and treatment of PTA deficiency have been suggested. We have concluded that if a coagulation screen for patients about to undergo oral surgery in a hospital is contemplated, either a partial thromboplastin time or a thromboplastin generation time should be included.

Adult↗
PubMed1976

Familial interstitial nephritis.

We report a family in whom sixteen members in three consecutive generations have died or currently suffer from chronic renal failure. Histology revealed an interstitial nephritis. One patient also had medullary cysts. The condition appears to be similar to familial juvenile nephronophthisis.

Adult↗
PubMed1976

T and B lymphocytes in patients with Down's syndrome.

Individuals with Down's syndrome are thought to have abnormalities of immune function. Studies to quantify the number of peripheral blood T and B lymphocytes and serum immunoglobulins in 12 individuals and 12 sex and age matched control subjects were performed. Hepatitis B antigen and antihyroglobulin antibodies as markers of possible immune dysfunction were determined. The numbers of circulating T and B cells, and the level of serum immunoglobulins in children with Down's syndrome did not differ from nonretarded control children. Circulating hepatitis B antigen and antihyroglobulin antibodies were not present. These studies indicated that quantitative abnormalities of T and B cells are not present in children with Down's syndrome. The data did not exclude the existence of qualitative abnormalities.

Antibodies↗
PubMed1976

Chromosome analyses of two recently established human tumour cell lines derived from a carcinoma of the oesophagus and a primary liver tumour.

An oesophageal carcinoma cell line was karyotyped at passages 8,48,64 and 88. It showed a persistent loss of D group chromosomes and subtelocentric, acrocentric, dicentric and other markers were frequently present. During 80 passages the modal number declined from 60,5 to 54,09. The chromosome pattern of a hepatoma cell line was studied at passages 15/17 and 28. It showed a loss of D and G group chromosomes and the presence of various markers including a D/G fusion.

Carcinoma, Hepatocellular↗
PubMed1975

Auditory evoked responses in multiple sclerosis.

The early components of the auditory evoked responses (waves I-V) have been studied in 30 patients with multiple sclerosis. There were abnormalities in 22 patients. All patients with an internuclear ophthalmoplegia and half those with no detectable brainstem abnormality had abnormal responses, although none was clinically deaf.

Adolescent↗