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Biomedical subjects

K Richardson

Publications and source records attributed to K Richardson.

At least 91 records · Page 5Linked to original sources
PubMed1979

Expanded linkage map of Vibrio cholerae.

An expanded linkage map of the Vibrio cholerae classical strain 162 chromosome has been prepared using a variety of new auxotrophic mutants. The chromosome consists of a single, linear linkage group. The map consists of 17 markers, which have been ordered; 20 mutational sites, which are tentatively ordered; five markers (ura-1, ser-2, mal-1, man-1, suc-1), which are linked but unordered; and three mutations (aro-2, cys-2 and cys-6) which showed little or no linkage. A proposal is made to standardize genetic nomenclature in V. cholerae genetic studies.

Chromosome Mapping↗
PubMed1979

Synthesis and antibacterial activity of 1-N-(1,3-dihydroxy-2-propyl)kanamycin B (UK-31,214).

1-N-(1,3-Dihydroxy-2-propyl)kanamycin B was prepared and its in vitro activity against aminoglycoside-sensitive and aminoglycoside-resistant organisms was compared with that of kanamycin B and gentamicin. This kanamycin B derivative (code No. UK-31,214) demonstrated potent activity in all of these tests and gave good protection in experimental infections in mice.

Aminoglycosides↗
PubMed1978

Increased aldosterone plasma protein binding in women on combined oral contraceptives throughout the menstrual cycle.

Plasma aldosterone concentration and the percentage of the fraction bound to a specific plasma aldosterone-binding globulin (ABG) were measured throughout the menstrual cycle in 26 healthy women aged between 19 and 38 yr who were receiving estrogen-containing oral contraceptives (OC), Midafternoon upright levels of total plasma aldosterone were similar in control and OC subjects and showed normal cyclic fluctuation in both groups. The percentage of ABG-bound aldosterone was markedly higher in OC subjects than in controls at all stages of the cycle and showed a positive correlation with the mean blood pressure when all OC subjects studied were considered. In addition, when the plasma ABG levels were measured 6 months or more after the start of medication, they appeared to be related to the dose of estrogen in the OC, but not to the length of time of its administration. The identity of plasma ABG in OC subjects with that in control subjects was also established.

Adult↗
PubMed1976

Developmental correlates of handedness in a national sample of 11-year-olds.

Some developmental correlates of hand preference in a large nationally representative sample of 11-year-old schoolchildren were examined. Non-right handedness was found to have slight, but statistically significant, associations with deficits of performance on certain standardized attainment and ability tests; with "poor speech" as assessed impressionistically by teachers in school; and with "poor control of hands" as similarly assessed by teachers. Non-right handedness was not associated with defects of articulation or stammering as assessed by doctors in a medical examination; nor withperformance on a clinical speech test; nor with writing productivity or syntactic maturity. There were substantial sex differences in the frequencies of non-right handedness, but no social class differences.

Child↗