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Biomedical subjects

K Rasmussen

Publications and source records attributed to K Rasmussen.

532 records · Page 30Linked to original sources
PubMedDate not supplied

Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats.

Single-unit recordings in anesthetized animals revealed that the L-type calcium channel antagonist, nimodipine (10 mg/kg), attenuated the activation of locus coeruleus neurons produced by naltrexone in opiate-dependent rats. Nimodipine also dose-dependently (1 mg/kg, 10 mg/kg, IP) inhibited the display of naloxone-precipitated withdrawal behaviors with a time course similar to that of nimodipine effects on the locus coeruleus. These data suggest that nimodipine may suppress opiate withdrawal via noradrenergic mechanisms.

Animals↗
PubMedDate not supplied

Incomplete development of the brain in a newborn with methylmalonic aciduria.

The investigation of the brain from a seven-day-old girl who died from a disorder in the metabolism of methylmalonic acid revealed a severe reactive gliosis of the cerebral white matter and the deeper layers of the cortex, incomplete development of the fetal granular layer of the cerebellum and the Bergmann glial cells, and delayed myelination of the cerebellum, the brainstem, and the cervical spinal cord. We suggest that some of the described neuropathological findings are an immediate consequence of a disturbed methylmalonic acid metabolism starting in utero, and not exclusively a secondary phenomenon due to accumulation of metabolites and acidosis postpartum.

Astrocytes↗
PubMedDate not supplied

Monitoring of pancreatic graft perfusion by first passage radionuclide angiography.

The perfusion of two pancreatic transplants were examined three times a week for the first five postoperative weeks by intravenous angiography using 99Tcm-pertechnetate. Worsening of the perfusion always preceded or was associated with deterioration of the pancreatic function. Accordingly, radionuclide angiography may have an important place in the systematic monitoring of pancreatic transplants in the critical postoperative period.

Adult↗
PubMedDate not supplied

Cytologic effects of Thiotepa and Adriamycin on normal canine urothelium.

An experimental investigation was carried out to produce and observe controlled, sequential changes in normal bladder urothelium of female dogs caused by Thiotepa (triethylene thiophosphoramide) and Adriamycin (doxorubicin hydrochloride). Thiotepa (30 mg in 30 ml saline) was instilled for two hours into the bladders of five dogs at weekly intervals, and Adriamycin (1 ml/kg body weight) was given intravenously to five dogs at weekly intervals for a period of ten weeks. Control animals underwent only bladder irrigation with saline. Periodic catheterized urine and saline bladder irrigations and bladder biopsy specimens were obtained. After the tenth week all dogs were killed and autopsies conducted. Major observations in the experimental animals included cellular enlargement, bizarre cell shapes, cytoplasmic vacuolization, nuclear and nucleolar enlargement, multinucleation, pyknosis, karyorrhexis and infiltration by neutrophilic leukocytes. In some animals, reversion to a normal cytologic pattern occurred in the ten-week period. The application of these observations to human urinary cytopathology is discussed.

Animals↗
PubMedDate not supplied

Evaluation of resident-in-training examination in cytopathology.

A cytopathology examination for residents was developed to determine its usefulness and ability to measure learning in cytopathology. Seventy-five resident-training programs participated in this study, which involved 143 beginning, 158 intermediate and 71 advanced residents as well as 63 pathologists and 118 cytotechnologists who considered themselves experienced practitioners. Scores increased significantly with training and practice (mean = 51%, 61%, 65%, 72% and 72%, respectively), although there was much overlap among groups. Of the 100 multiple-choice questions, the 50 involving interpretation of photographs produced the highest scores and greatest differences between advanced residents and experienced practitioners. Visual recognition and grading of cancer cells and visual recognition of normal cellular elements were the areas of greatest resident weakness. Resident recognition of verbal criteria was worse than visual recognition. Different strengths were identified for pathologists and cytotechnologists.

Allied Health Personnel↗