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Biomedical subjects

K Rasmussen

Publications and source records attributed to K Rasmussen.

At least 325 records · Page 18Linked to original sources
PubMed1985

Locus coeruleus unit activity in freely moving cats is increased following systemic morphine administration.

Contrary to previous reports of morphine's depression of locus coeruleus (LC) unit activity in anesthetized animals, acute administration of morphine (0.5, 2.0 or 4.0 mg/kg, i.p.) did not decrease the unit activity of noradrenergic neurons in the area of the LC of freely moving cats. In fact at the higher doses examined (2.0 and 4.0 mg/kg) morphine significantly increased unit activity. Naloxone (1 mg/kg, i.p.) administration reversed the increase in unit activity produced by morphine. When these same studies were conducted in cats first anesthetized with chloral hydrate, morphine produced a significant decrease in unit activity in a naloxone-reversible manner. These results suggest that previous reports of systemic morphine's depression of LC unit activity may be at least partially attributable to an interaction with anesthesia. Morphine's multiplicity of actions upon the LC is discussed.

Adrenergic Fibers↗
PubMed1985

Transseptal left heart catheterization with a Swan-Ganz flow-directed catheter: review of 173 studies.

Of 178 transseptal left heart catheterizations performed, 173 successful cases are reported, with the use of a Swan-Ganz, flow-directed, balloon-tipped catheter. By means of a modified Brockenbrough technique, which is described in detail, a 10F Teflon tube (3.3 mm outside diameter) was inserted into the left atrium. Through the tube, which was continuously flushed with saline solution, a 5F Swan-Ganz catheter was introduced into the left atrium. In all cases where left atrial puncture was possible (n = 173), the left ventricle was easily entered, even in the presence of mitral stenosis. Two major complications with signs of cerebral embolism occurred in this series. The method is technically reliable and acceptably safe in cases where the transseptal route of left heart catheterization is required.

Adolescent↗
PubMed1985

Ten years of infective endocarditis: a clinicopathologic study.

The records of 46 patients with infective endocarditis diagnosed either clinically or post-mortem were analyzed. Twenty-six patients were over 60 years of age. S. aureus was the predominant organism, almost exclusively found in patients with acute endocarditis. Thirty-six patients had pre-existing heart disease, the most common being non-rheumatic valvular calcification and congenital defects. Two thirds of the patients, especially those with aortic valve regurgitation, developed new or progressive heart failure. A correct clinical diagnosis was established in only 30 patients. Twenty-three patients died, the mortality being 71% in acute and 32% in subacute disease. Only one of eight patients with prosthetic valve infection died. Four patients required urgent valve replacement. Early surgical intervention should be considered in patients with uncontrolled heart failure.

Adolescent↗
PubMed1985

Vasospastic ischaemia induced by the hyperventilation test in patients with a negative response to ergometrine.

We present the case histories of two patients with angina pectoris who developed coronary artery spasm in response to provocation with prolonged hyperventilation (verified by ST segment elevation in both and coronary angiography in one) despite a negative ECG response to intravenous injection of 0.4 mg ergometrine. This new observation, which is in conflict with recent publications stating that ergot provocation is more sensitive than hyperventilation, suggests that in some patients diagnostic provocation with hyperventilation may be an alternative to the widely used ergot provocation.

Adult↗
PubMed1985

Male breast cancer from pacemaker pocket.

One year following implantation of a mercury zinc pulse generator under the right breast, a 75-year-old man developed an ulcerative tumor of the nipple. Initially, the process was misinterpreted as a pacemaker pocket infection, until a diagnosis of papillary adenocarcinoma was made. The patient died from generalized metastases. To our knowledge, the association of a pacemaker implant and male breast cancer has not been previously reported; the probability of this occurring by chance seems rather low.

Adenocarcinoma, Papillary↗
PubMed1985

Renal function in 153 manic-depressive patients treated with lithium for more than five years.

Renal function was examined in 153 manic-depressive patients treated with lithium for more than 5 years, mean 10 years. No significant change was detectable in plasma creatinine. Glomerular filtration rate (GFR) decreased slightly, but significantly, and not until after 17 years of treatment did the regression line reach the lower confidence limit in the reference material. GFR was generally only moderately decreased. Renal concentrating capacity was significantly reduced during the whole investigation period and did not change with time. GFR was independent of the dosage pattern. The diuresis did not differ markedly in patients given one or three daily doses. In a two-dose group predominantly treated with slow-release tablets, the diuresis was somewhat higher in 75% of the patients but much higher for the rest of the group. Since the prophylactic effect of lithium was the same in the one-dose group (mean dosage 21 mmol/day) as in the two-dose and three-dose groups (mean dosage 27-28 mmol/day), our data indicate that generally employed lithium doses may be reduced somewhat without loss of prophylactic efficacy.

Adult↗
PubMed1985

Balanced terminal chromosome translocations develop in EBV-derived, but non-immortal cell lines from patients with mycosis fungoides.

Five lymphoblastoid cell lines established from patients with mycosis fungoides were followed during long-term culture. They all expressed the Epstein-Barr virus nuclear antigen. Although the established B-cell lines initially showed a normal karyotype, metaphases with balanced terminal translocations gradually occurred. These chromosome abnormalities occurred simultaneously with decreased cell proliferation leading in all cases to termination of the cell lines. This contrasts the usual finding that Epstein-Barr virus established B-lymphoblastoid cell lines are immortal.

B-Lymphocytes↗
PubMed1985

Effect of acetate and bicarbonate dialysis on cardiac performance and transmural myocardial perfusion in patients with renal failure.

The object of the present study was to assess the haemodynamic changes measured by impedance cardiography during acetate and bicarbonate dialysis in uraemic patients without cardiovascular diseases. It was demonstrated that the cardiac output increased significantly after 60 minutes during acetate dialysis compared with bicarbonate dialysis while the peripheral resistance decreased significantly during acetate dialysis. As estimated by the diastolic systolic pressure time index ratio myocardial perfusion fell significantly following acetate dialysis as compared to bicarbonate dialysis. It is concluded that the work of the heart increases during acetate dialysis. This involves risk of myocardial hypoperfusion. It is therefore recommended that bicarbonate dialysis is the choice for patients with unstable circulation and/or ischaemic heart disease.

Acetates↗
PubMed1984

Mapping of subsites in the combining area of monoclonal anti-galactan immunoglobulin A J539.

Monoclonal immunoglobulin A J539 binds beta-(1----6)-D-galactopyranans. Measurement of the affinity of its Fab' fragment for a series of galacto oligosaccharides--some of which carried deoxyfluoro groups--has made it possible to assign a binding mode of the polysaccharide that has the reducing end oriented from the heavy (H) chain toward the light (L) chain. In addition, the values obtained for the affinity constants of the immunoglobulin with these oligosaccharides, as well as the maximal values obtained for the intrinsic ligand-induced fluorescence, permit a deduction about the relative affinity of the protein's four subsites for each galactose residue of the tetrasaccharide fragment it can bind. If these subsites are labeled C, A, B, and D, going from the H-chain toward the L-chain across the face of the immunoglobulin combining area, then the order of decreasing affinity is A greater than B greater than C greater than D.

Antibodies, Monoclonal↗