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Biomedical subjects

K Rasche

Publications and source records attributed to K Rasche.

15 recordsLinked to original sources
PubMed1991

[Assessment of cyclic and phasic oxygen saturation using pulse oximetry in the diagnosis of nocturnal respiratory disorders].

Nocturnal pulse oximetry is frequently used in screening studies when diagnosing nocturnal respiratory disorders. Short-term cyclic desaturations of oxygen can serve to indicate recurring apnoeas, whereas long-lasting phasic reductions of oxygen saturation are predominantly seen in hypoventilation. However, there are no uniform assessment criteria. We developed a computer programme for the differentiated assessment of cyclic and phasic oxygen desaturations. With this programme it is possible to characterise the individual phases in respect of gradient and duration of the decrease in oxygen saturation, of the starting, minimal and final values and the total duration of the desaturation phase. This enables determination of the rate of incidence of various forms of desaturation during nocturnal recording. The results of this differentiated analysis of nocturnal pulse oximetry in patients with sleep apnoea syndrome (n = 6) and with chronic obstructive airways disease with respiratory insufficiency (n = 6) and without respiratory insufficiency (n = 6) are demonstrated as model examples.

Apnea↗
PubMed1991

[Nocturnal oxygen saturation in patients with coronary heart disease--dependent on degree of left ventricular functional impairment].

It is assumed, that patients with coronary heart disease (CHD) more often suffer from sleep related disorders of breathing than healthy subjects. A relation to an impaired left ventricular performance is discussed. In 40 CHD-patients and 30 cardio-respiratory healthy controls we therefore measured arterial oxygenation during sleep by means of pulse-oximetry. Our results show a marked increase in the frequency of nocturnal oxygen-desaturations along with the degree of impaired left ventricular function independent of a special sleep apnea risk. In case of cardiac insufficiency at rest cyclical oxygen-desaturations were observed ten times as often as in the healthy controls. A central disturbance of the respiratory control, which leads to periodic breathing (type Cheyne-Stokes) has to be discussed. Because of the general high risk of CHD-patients concerning the development of nocturnal complications of their disease, sleep-related disturbances of ventilation have to be detected early by means of routinely applied screening-methods.

Adult↗
PubMed1990

[Sleep apnea].

Explore the source record for details and available documents.

Adult↗
PubMed1990

[Pulmo cardialis: effect of inhaled bronchodilators on airway resistance of acute left ventricular dysfunction].

Disturbance of left ventricular function leads to an impairment of ventilation: airway resistance increases, while pulmonary compliance is reduced. We therefore studied the effect of inhalable bronchodilators (Fenoterol, Ipratropium bromide) on oscillatory airway resistance in 16 patients with an acute left heart failure. The results show that the resistance can be significantly reduced to normal values by the bronchodilators. Fenoterol has the greatest spasmolytic potency, but Ipratropium bromide is also effective. Recompensation of left heart function alone does not lead to comparable acute effects on airway resistance. The possibility of immediate improvement of ventilation through the use of inhalable bronchodilators should therefore be considered in the treatment of acute left heart failure.

Airway Resistance↗
PubMed1989

[Mucoviscidosis: late diagnosis despite typical clinical features].

An 18-year-old girl was hospitalized because of a treatment-refractory broncho-pneumonia requiring artificial ventilation. She had been suffering from recurrent respiratory infection since the age of three years. Chest X-ray films demonstrated bronchiectasis: Pseudomonas, Klebsiella and Candida albicans were isolated from the respiratory tract. The correct diagnosis of the underlying disease had not previously been made. A sweat test, when aged 15 years, was borderline abnormal. Despite the application of all available therapeutic measures she died in cardiorespiratory failure from an overwhelming pulmonary infection. The typical clinical features and the findings at autopsy established the diagnosis of mucoviscidosis.

Adolescent↗
PubMed1989

[Comparison of respiratory control responses in bronchial and external airway stenosis].

Respiratory responses during allergen-induced airway obstruction and external airway stenosis were investigated in anaesthetised sheep. The results were compared to those obtained from healthy subjects during external airway stenosis. Allergen-induced increase in airway resistance results in an increased respiratory frequency, mainly due to a shortening of expiration (TE) and only partially due to a shortening of inspiration (TI). Tidal volume is diminished while respiratory changes in oesophageal pressure (delta Poes) are increased. Both results in an increase of dynamic elastance (Edyn) representing airway resistance. Based on the increase in the slope and amplitude of inspiratory pressure (delta Poes/TI), the mean inspiratory airflow (VT/TI) remains almost unchanged. In spite of an increased ventilation PaO2 decreases, whereas PaCO2 increases only slightly. External airway stenosis, however, results in a decrease of respiratory frequency, mainly depending on a prolongation of inspiration. Changes in Poes and VT are similar to those of allergen-induced airway obstruction. delta Poes/TI, however, increases less than during allergen application and results in a decrease of mean inspiratory airflow, tidal volume and ventilation. Respiratory responses of healthy subjects during external airway stenosis were similar to those described in experimental animals. The results of our investigation show a different pattern in the control of breathing during bronchial and external stenosis-induced airway obstruction and thus indicate different vagal reflex mechanisms.

Airway Obstruction↗
PubMed1987

[Asbestosis and the rheumatic lung. Medical insurance assessment of combined lung diseases].

A fibrosing pulmonary disease, which could not be further classified, was diagnosed in a 76-year-old woman who for 40 years had worked as a seamstress in the textile industry. For the last 16 years she had suffered from progressively increasing shortness of breath. She died three weeks after hospitalization during which she received intensive respiratory and circulatory supportive treatment. At post-mortem examination there was evidence of minimal asbestosis, of pulmonary manifestations of rheumatoid arthritis and of recurrent pulmonary thromboembolism, as well as of the consequences of two weeks of artificial ventilation during the terminal period. This constellation of histopathological findings was assessed in relation to the part played by her occupational disease. She had been previously awarded a pension as a recognized sufferer form asbestosis (50% reduction of earning power). The histopathological findings were not such--in view of the difficult diagnostic constellation while she was alive--as to contradict with a high degree of probability the finding that she had suffered from an occupational disease.

Aged↗