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Biomedical subjects

K Rahal

Publications and source records attributed to K Rahal.

At least 55 records · Page 3Linked to original sources
PubMed1995

[Breast angiosarcoma. Five case reports].

The authors report 5 cases of breast angiosarcoma collected in the Salah Azaiz Institute of Tunis, the only oncology center in this country, between 1969 and 1990. They enumerated 4,000 malignant breast tumors during this period; i.e. an incidence of 1.25%, higher than that in the world literature (0.4%). The mean age of patients was 44. Three were post-menopausal, and two were of childbearing age, one of whom was pregnant. This rare tumor is virtually limited to women. Affection is scarce, it affect's almost exclusively women. It generally present as a painless, ill-defined mass, without regional lymphadenopathy. The diagnosis of angiosarcoma is difficult since the histologic appearance is sometimes identical to that of a hemangioma. Hence the value of very thorough histologic examination of the entire operative specimen. Treatment is based upon mastectomy. The usefulness of adjuvant chemotherapy and/or radiotherapy is uncertain. The prognosis remains gloomy despite early diagnosis and treatment. The authors attempt in this study to identify the various features of this serious and uncommon condition, based upon the rare published cases in the world literature.

Adult↗
PubMed1995

[Struma ovarii. Three malignant cases and one benign case].

Four cases of struma ovarii were seen among 308 ovarian tumors removed surgically at the Salah Azaiz Institute, Tunis, Tunisia, between 1980 and 1989. This yields an occurrence rate of 1.3%, which is comparable to previously publishes rates (0.3% to 2%). One of the four tumors was malignant. Malignant transformation of struma ovarii is very rare (5% to 10%). The histologic diagnosis of malignancy is difficult, particularly in well-differentiated follicular forms. The prognosis is relatively favorable even in patients with metastases. Based on their personal experience and on a review of the literature, the authors discuss the diagnosis, management, and outcome of struma ovarii, in particular with malignant transformation.

Adult↗
PubMed1994

[Granular cell tumors of the breast. Apropos of two cases].

Granular cell tumors of the breast are rare. The clinical presentation, the poor macroscopical delimitation and the infiltrating appearance of the tumor cells between the mammary lobules and within the adipose tissue may lead to a diagnosis of carcinoma, especially on frozen section. The authors present two cases of granular cell tumor of the breast occurring in two women aged 19 and 59 respectively. Before surgery, the diagnosis was that of a malignant tumor. In both cases, frozen section suggested the diagnosis of a granular cell tumor, which was confirmed by immunohistochemical study in one patient.

Adult↗
PubMed1994

[A nosocomial epidemic of Salmonella mbandaka which produces various broad spectrum beta-lactamases: preliminary results].

During a nosocomial epidemic of Salmonella mbandaka in Algeria, 99 strains were isolated from specimens. Study of 22 of them revealed minimum inhibiting concentrations ranged from 4 to 32 micrograms/ml for cefotaxime, 2 to 32 micrograms/ml for ceftazidime and 2 to 16 micrograms/ml for ceftriaxione. The mechanism underlying resistance was enzymatic with production of broad-spectrum beta-lactamase enzyme. Clavulinic acid at a dose of 2 micrograms/ml restored the activity of hydrolyzed beta-lactamases. Resistance to all antibiotics including cefotaxime was due to a single plasmid structure. The plasmid did not belong to any known compatibility group. All strains studied contained a plasmid of 26MDa and produced TEM-1 and TEM-2 beta-lactamases. Strains resistant to cefotaxime also synthetized a broad-spectrum beta-lactamase derived from TEM.

Algeria↗
PubMed1992

[Post-streptococcal immunity in the child in acute articular rheumatism (R.A.A.) or recurrent sore throats].

It concerns comparative studies between two children groups: One group who had previous RAA. A second group who had anginas only. This work shows the interest to associate two streptococcal serologic tests (ASLO, ASD) in order to increase the number of recent diagnostic streptococcal infectious. The remaining immunity is missing in children less than 5 years old; more than 50% of above 10 years an antistreptococcal answer although they have not streptococcus infections presently.

Adolescent↗
PubMed1992

[Prospective study of Listeria in humans and animals].

During 1967 to 1985, three cases of listeriosis were reported in Algeria; at that time Listeria monocytogenes caused several thousand cases of meningitis and sepsis in the world. In order to determine the frequency and bacteriologic characteristics of strain isolated in Algeria, a prospective investigation was carried from 1985 to 1989 in humans and animals samples. Sensitivity tests to antibiotics (MIC) point out that all isolates strains are resistant to cephalosporins (first and third generation), but are susceptible to Ampicillin and Gentamicin which ought to constitute the treatment basis of listeriosis.

Abortion, Veterinary↗
PubMed1992

[Listeria serotyping].

Serotyping of Listeria has contributed to bring to light on the origin of outbreaks listeriosis; on the other hand, it is also an additional expression for the identification of Listeria genus. In order to get better in this field, we have produced five factors sera: I, I/II, V/VI, VI, VII.

Animals↗
PubMed1992

[Comparative activities in vitro of 4 quinolones (nalidixic acid, pefloxacin, norfloxacin, ofloxacin) on 13 bacterial species].

Nalidixic acid and three fluoroquinolones were tested on 389 strains belonging to 13 bacterial species, all isolated in Algeria. Ofloxacin, norfloxacin and pefloxacin have the same activities on E. coli, Acinetobacter and S. aureus. Norfloxacin has the best activity on Proteus, Enterobacter, Shigella and Klebsiella. Norfloxacin and ofloxacin have the same activities on S. typhi, Salmonella and choleric Vibrio. Norfloxacin has the same activity than pefloxacin on P. aeruginosa. It is necessary to prescribe a quinolone in the right way and to consider the pharmacokinetic properties.

Anti-Infective Agents↗
PubMed1992

[Resistance to new quinolones among the enterobacteria].

We report the isolation of 10 strains of enterobacteriaceae with a new quinolone's resistance. This resistance was detected by a diminution of inhibition's diameter around the disk of pefloxacin , and confirmed by the determination of Minimal Inhibiting Concentrations (M.I.C.). These strains, moreover multiresistant to multiple antibiotics, were isolated from patient's urines with repetitive urinary tract infections (paraplegics, lithiasic patients). None of this patients was treated by new quinolones. The incorrect use of old quinolones is probably responsible for the selection of this new quinolone's resistance.

Drug Resistance, Microbial↗
PubMed1992

[Peritonitis caused by Nocardia farcinica in a patient undergoing continuous ambulatory peritoneal dialysis (note)].

We report here an isolation of bacteria genus Nocardia, Nocardia farcinica, in a dialysis liquid of a renal insufficiency patient treated by continuous ambulatory peritoneal dialysis (C.A.P.D.). Real peritonitis was due to infection with this bacteria, eliminated after an adapted antibiotherapy. This observation is interesting first because of the rare occurrence of Nocardia's peritonitis in the patients on CAPD, and secondly in relation with the species of Nocardia, Nocardia farcinica, less known than Nocardia asteroides but not less pathogenic.

Adult↗
PubMed1992

[Salmonella m'bandaka isolated in a nursery].

A epidemic of enteric pathogens bacteria occurred in december 1989 and caused two deaths in a nursery. There were many investigations between december 1989 and september 1990 trying to clarify this epidemic context. A new serovar of Salmonella had for the first time been isolated from babies' feces in Algeria. Salmonella m'bandaka has been identified in more than 50% of analysis. During an hygienic investigation in this nursery the above Salmonella m'bandaka was isolated in a open physiologic solution flask.

Algeria↗
PubMed1989

Inflammatory symptoms in breast cancer. Correlations with growth rate, clinicopathologic variables, and evolution.

Based on two pretreatment evaluations, doubling time (DT) was calculated in 75 cases of invasive breast cancer (BC). The cases studied were more or less equally distributed between three DT groups: fast-growing tumors (DT less than 90 days), intermediate cases (DT between 90 and 180 days), and slow-growing tumors (DT greater than 180 days. A correlation was found to exist between DT and patient age and, to an even greater extent, between DT and pathologic prognostic indicators such as histologic grading and nuclear grade. Inflammatory symptoms were not associated with DT, but were closely related to the size of the tumor and regional lymph node involvement. The date of detection of distant metastases depended heavily on the DT of the BC:BC with shorter DT = earlier metastatic spread. The presence of inflammatory signs was also decisive: within each DT category, inflammatory BC metastases were both more frequent and precocious.

Adult↗
PubMed1989

[Antibiotic sensitivity of strains of Klebsiella isolated in Geneva and Algiers].

573 strains of Klebsiella were isolated in Geneva (239 strains) and in Algiers (334 strains). The complete work with bacteriologic features (culture, biochemistry and antigenicity) will be published later. Two investigations took place in surgical cardio-vascular service in Geneva cantonal hospital and in Algiers hospitals: Pediatric (Beni-Messous) and intensive care service (Mustapha). High resistance percentages are found with Penicillins (greater than 60% by C.M.I.) in Geneva and Algiers. The strains are susceptible to aminoglycosides: in Algiers, 8.68% strains are resistant to Gentamicin and 5.99% to Tobramycin. In Geneva, all the strains are susceptible to Aminoglycosides. All the strains are susceptible to Trimethoprim and the Furans resistant strains are rare. The C.M.I. test is more precise than disc diffusion technique, especially for Penicillin and Furans. Cephalosporins and aminoglycosides are the best choice for treatment of Klebsiella infections.

Adult↗
PubMed1989

[Informatics: applications in bacteriology].

The subject of this work is to describe one of the possible applications of the informatics system in medical bacteriology, its exploitation in edition of the analysis results and in the management of produced stocks. The informatics is presently a very productive tool giving a precise information, a very important time gain and a better control of the costs. This work admit two chapters. In the first one, we give general notions of informatics and in the second one we describe the applications.

Algeria↗
PubMed1989

[Activity of cefotaxime and ceftriaxone and of imipenem, pefloxacin and norfloxacin on 13 species of bacteria].

A first comparative in vitro study of Cefotaxime and Ceftriaxone activities on thirteen species of Algerian bacteria is done. These two third generation Cephalosporins have the same activity. A second comparative study of two Quinolones (Pefloxacin, Norfloxacin ) and a Penicillin (Imipenem) is done. Imipenem give satisfying results and is very stable against beta lactamases. In vitro Norfloxacin has a better activity than Pefloxacin.

Bacteria↗
PubMed1988

[Gastric adenocarcinoma surgically treated. A multivariate analysis of prognostic factors].

One hundred and twelve curatively resected gastric adenocarcinomas were studied retrospectively to appreciate the survival factors. Twenty different criteria (clinic, histologic and therapeutic parameters) were assessed using univariate and then multivariate analysis (semi parametric regression (COX's) model). Only three criteria were very important according to the multivariate analysis: 1) invasion of neighboring organs (p less than 0.006) with a relative risk score (RRS) of 4.26; 2) intravascular or intralymphatic tumor embols outside the tumor (p less than 0.004; RRS = 2.11); 3) invaded distal nodes (located at the origin of the vessels (p less than 0.04; RRS = 1.88). A prognosis index was described according to these results. A repartition of the patients in three prognostic groups according to these 3 criteria was proposed. Future, trials should consider these three different prognostic groups.

Adenocarcinoma↗