Biomedical subjects

K Ragsdale

Publications and source records attributed to K Ragsdale.

4 recordsLinked to original sources

PubMed1999

Detection and treatment of depression in a VA primary care clinic.

The Veterans Health Administration clinical guideline for major depressive disorder was used in screening 574 male veterans treated in primary care settings in the Department of Veterans Affairs health care system. Thirteen percent (N=73) screened positive for depression, and 33 percent of those patients showed evidence of a major depressive episode. Pre- and posttreatment assessment of a sample of 16 patients treated for depression in a primary care setting revealed statistically significant improvement with treatment.

Adult↗

PubMed1996

Mechanism and size cutoff for steric exclusion from actin-rich cytoplasmic domains.

Subdomains of the cytoplasmic volume in tissue culture cells exclude large tracer particles relative to small. Evidence suggests that exclusion of the large particles is due to molecular sieving by the dense meshwork of microfilaments found in these compartments, but exclusion as a result of the close apposition of the dorsal and ventral plasma membrane of the cell in these regions has not been ruled out conclusively. In principle, these two mechanisms can be distinguished by the dependence of exclusion on tracer particle size. By fluorescence ratio imaging we have measured the partition coefficient (P/PO) into excluding compartments for tracer particles ranging in radius from 1 to 41 nm. The decay of P/PO as a function of particle radius is better fitted by three molecular sieving models than by a slit pore model. The sieving models predict a percolation cutoff radius of the order of 50 nm for partitioning into excluding compartments.

3T3 Cells↗

PubMed1996

Random versus nonrandom assignment in controlled experiments: do you get the same answer?

Psychotherapy meta-analyses commonly combine results from controlled experiments that use random and nonrandom assignment without examining whether the 2 methods give the same answer. Results from this article call this practice into question. With the use of outcome studies of marital and family therapy, 64 experiments using random assignment yielded consistently higher mean post-test effects and less variable posttest effects than 36 studies using nonrandom assignment. This difference was reduced by about half by taking into account various covariates, especially pretest effect size levels and various characteristics of control groups. The importance of this finding depends on (a) whether one is discussing meta-analysis or primary experiments, (b) how precise an answer is desired, and (c) whether some adjustment to the data from studies using nonrandom assignment is possible. It is concluded that studies using nonrandom assignment may produce acceptable approximations to results from randomized experiments under some circumstances but that reliance on results from randomized experiments as the gold standard is still well founded.

Family Therapy↗

PubMedDate not supplied

Comparison of intensive outpatient cardiac rehabilitation to standard outpatient care in veterans: effects on quality of life.

BACKGROUND: Examination of the effect of cardiac rehabilitation (CR) on quality of life has been relatively limited. The current study examined existing clinical data, which had been obtained during the course of program evaluation. Changes in quality of life for patients who participated in an intensive rehabilitation program and those who had received standard outpatient care only were compared. METHODS: Quality-of-life changes in cardiac patients (n = 87) from two treatment groups were compared. Patients had either participated in an 8-week intensive CR program (n = 45) consisting of monitored exercise 3 days weekly and inter-disciplinary education sessions, or routine outpatient clinic services (n = 42). RESULTS: Patients in the intensive CR program demonstrated significant (P < 0.05-< 0.001) improvement in all areas of quality of life assessed. In contrast, patients that received routine outpatient care did not demonstrate any areas of improvement, while Vitality was significantly (P < 0.05) poorer at posttest. CONCLUSIONS: Our results suggest that provision of more intensive outpatient CR can improve quality of life more than standard outpatient care.

Ambulatory Care↗