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Biomedical subjects

K Petersen

Publications and source records attributed to K Petersen.

At least 109 records · Page 6Linked to original sources
PubMed1984

Do antihypertensive drugs precipitate diabetes?

A longitudinal population study of 1462 women aged 38-60 was carried out from 1968-9 to 1980-1 in Gothenburg, Sweden. The initial and follow up examinations included questions concerning history of diabetes and antihypertensive treatment. A considerably increased risk of developing diabetes was observed for subjects with hypertension taking diuretics (895 patient years), subjects taking beta blockers (682 patient years), and subjects taking a combination of diuretics and beta blockers (281 patient years) compared with subjects not taking antihypertensive drugs (13 855 control years). When diuretics and beta blockers were compared no difference was found in relative risk. Despite this increased risk, and because little is known about the relation between other forms of antihypertensive treatment and diabetes, diuretics and beta blockers should remain the treatments of choice in arterial hypertension.

Adrenergic beta-Antagonists↗
PubMed1984

Evidence of altered dopaminergic modulation of Prl, LH and TSH secretion in patients with normoprolactinaemic amenorrhoea.

Basal plasma concentrations of Prl, LH, FSH, GH, TSH, T3, T4, resin T3 uptake ( RT3U ), and oestradiol as well as hormone responses to iv metoclopramide (MTC) were investigated in 16 consecutive patients with normoprolactinaemic, normogonadotrophic amenorrhoea. The control group consisted of 17 normal menstruating women between day 3 and 6 of the menstrual cycle. The mean age of the amenorrhoeic patients was 24.0 years (range 19 to 34) and the mean duration of amenorrhoea was 31 months (range 12 to 60). Amenorrhoeic patients had significantly (P less than 0.05) lower basal levels of LH, oestradiol and RT3U , whereas other hormone levels were similar in the two groups. Plasma Prl and TSH concentrations rose significantly (P less than 0.05) after the administration of MTC in the two groups. A significant positive correlation (r = 0.69 P less than 0.01) was found between the TSH response to MTC and basal TSH levels in controls, but not in amenorrhoeic patients. Plasma LH levels increased significantly (P less than 0.05) in amenorrhoeic patients, but not in controls. The Prl and TSH responses to MTC were significantly (P less than 0.001) lower in amenorrhoeic patients than in normal women. In amenorrhoeic patients none of the hormonal parameters correlated significantly (P greater than 0.05) with the percentage of ideal body weight. It is concluded that the hormonal changes in amenorrhoeic patients may in part be caused by a raised dopaminergic activity leading to a depression of central ovulatory mechanisms.

Adult↗
PubMed1977

Influences of environmental conditions during infancy on final body stature.

In the following article we shall investigate the Second World War with its consequences on nutrition and other living conditions for the German population to try to determine whether lack of nutrition plus other deficiencies, which infants were subjected to in Germany during this time, had any influence on their adult stature. The following data formed the basis of our investigation: (1) nutrition of infants and school-aged children during the years 1939-1948; (2) stature and weight of 6-year-old boys between 1907 and 1948; (3) infant mortality between 1935 and 1950; (4) stature of 19-year-old men who were born between 1938 and 1951. From Figure 5 it can be seen that the mean stature of 19-year-old men born between 1938 and 1951 (except for those born in 1944 and 1945) rose steadily (secular acceleration). The plot of the yearly rate of acceleration (Fig. 6) reveals a minimum in 1944-1945, and follows a general downward, U-shaped trend (P less than 0.05). On the other hand, infant mortality between 1941 and 1949 follows an upward U-shaped trend (P less than 0.05). For the 6- to 8-month-old infants during 1945-1948 nutrition was far worse than that during the preceding years. It is even likely that the nutrition for the infants had already begun to decrease in quality in 1942. We find, therefore, a close correlation between the years of high infant mortality and the growth deficiencies of the men born during these years. Since we must assume that the nutritional situation for babies and infants worsened steadily after 1942 until it is apparent that a number of environmental factors directly influence human growth. The conclusion of our analysis is that a deficit of growth occurring after the end of the fourth year can be compensated fully. We conclude, furthermore, that the growth deficits which arise before the fourth year, on the other hand, cannot be compensated fully even if good or excellent environmental conditions follow.

Adolescent↗
PubMed1977

The effect of blood-transfusions on renal allograft survival.

The relation between previous bloodtransfusions and renal allograft survival was studied retrospectively in 88 patients, who had been transplanted for the first time. The allograft survival rate was higher in the group who had received bloodtransfusion than in the group who had not. This difference was significantly greater when considering patients who had not previously been pregnant, e.g. patients without previous stimulation of the immuno system. The material shows no difference in allograft survival between previously transfused and non transfused patients, when considering age, sex or disease of kidney. In this retrospective study it is concluded that previous transfusions improved the prognosis of the transplantation. A prospective study has yet to be done, in order to enlighten the influence of various other factors on the allograft survival rate such as length of period or uraemia and of dialysis.

Adolescent↗
PubMed1976

Rehabilitation of Danish dialysis and transplant patients.

An evaluation of the extent of rehabilitation of 512 Danish dialysis and transplant patients, based on a questionnarie, has been carried out. All transplanted patients and dialysis patients and dialysis patients with only slightly limited working capacity before treatment experienced an improvement, whereas disabled dialysis patients did not experience major changes. Sixty per cent of the patients receive disablement pension and the allotment of pension early in the course of treatment is suspected to be one of the main reasons for the low degree of vocational rehabilitation.

Absenteeism↗