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Biomedical subjects

K Paul

Publications and source records attributed to K Paul.

At least 109 records · Page 6Linked to original sources
PubMed1981

[The development of falling asleep during the first months of life in man (author's transl)].

Ten normal infants were studied at 2, 6, 12 and 20 weeks of age. EEG, respiratory rhythm, eye movements and chin EMG were recorded after the evening meal. Recording was continued during the stages of sleep. During the period of falling asleep the periods of REM sleep have been analyzed and compared with the periods of REM sleep occurring after non-REM sleep. REM sleep occurring on falling asleep and that occurring after non-REM sleep differed. Some of the following criteria were different at the earliest time of examination; absence of chin EMG activity, number of apnoeic episodes; other criteria (eye movements, respiration) differed during the first 5 months. The large number of eye movements at 2 and 6 weeks and the high respiratory rate, corresponding to that occurring during waking, could indicate that during REM sleep occurring on falling asleep, one is observing manifestations connected with the waking state.

Electroencephalography↗
PubMed1977

Responsiveness to stimulation during paradoxical sleep in infants.

11 healthy children were repeatedly studied during 2 sleep cycles in 2 sessions at 2,6, 12 and 20 wk of life. Three acoustic stimuli, light and tactile stimulus were applied in a randomized order in intervals ranging randomly from 30 to 120 sec. Continuous polygraphic recordings were made of respiration, REMs, EEG and EMG of biceps and triceps brachii. The effect of stimuli on the length of paradoxical sleep, REMs and EMG was assessed. There were age-related changes in the number of REMs after stimuli. At 2 and 6 wk no stimulus elicited any change. At 12 wk the children responded with an increased number of rapid eye movements to acoustic stimuli, at 20 wk they responded to acoustic stimuli and light. The conclusion is that, as far as REMs are concerned, responsiveness during paradoxical sleep changes with age. There was a difference in the incidence of EOG responses and EMG responses. These findings show that it is not possible to assess responsiveness in infants during PS by one measure only.

Acoustic Stimulation↗
PubMed1976

5-Aryloxy-6-methoxy-8-aminoquinolines as potential prophylactic antimalarials.

5-(p-Anisyloxy)-6-methoxy-8-(5-isopropylaminopentylamino)quinoline was resynthesized for evaluation in the Plasmodium berghei and monkey prophylactic (Plasmodium cynomolgi) tests. A new primary amine, three secondary amines, and one structurally modified side-chain analog of the 5-aryloxy series were also prepared. None of these compounds showed significant antimalarial or prophylactic activity.

Aminoquinolines↗
PubMed1976

Individual differences in infants' sleep.

Individual differences in sleep patterns were repeatedly studied in 22 infants in a residential unit for mothers and babies at two, six, 12 and 20 weeks of age. Electroencephalogram, horizontal and vertical electro-oculogram, electromyogram of chin muscle, and respiration and body movements were recorded during the first two sleep cycles. The age factor was significant in all variables studied. The infants' individuality was significant in (1) the frequency of respiration during quiet sleep, (2) the frequency of rapid eye movement during paradoxical sleep, (3) the occurrence of regular EEG activity during paradoxical sleep, and (4) body movements during paradoxical sleep. Individual differences in these sleep variables persisted with considerable stability during the first five months of life.

Electroencephalography↗